Gallic Acid

Publication Title: 
Journal of Alzheimer's disease: JAD

The present study explored the bioavailability and brain deposition of a grape seed polyphenolic extract (GSPE) previously found to attenuate cognitive deterioration in a mouse model of Alzheimer's disease (AD). Plasma pharmacokinetic response of major GSPE phenolic components was measured following intragastric gavage of 50, 100, and 150 mg GSPE per kg body weight. Liquid chromatography-mass spectrometry (LC-MS) analysis identified gallic acid (GA), catechin (C), and epicatechin (EC) in plasma of rats gavaged acutely with GSPE.

Author(s): 
Ferruzzi, Mario G.
Lobo, Jessica K.
Janle, Elsa M.
Cooper, Bruce
Simon, James E.
Wu, Qing-Li
Welch, Cara
Ho, Lap
Weaver, Connie
Pasinetti, Giulio M.
Publication Title: 
Molecules (Basel, Switzerland)

Hypochlorite is a strong oxidant able to induce deleterious effects in biological systems. The goal of this work was to investigate the use of PGR and PYR as probes in assays aimed at evaluating antioxidant activities towards hypochorite and apply it to plant extracts employed in Chilean folk medicine. The consumption of PGR and PYR was evaluated from the decrease in the visible absorbance and fluorescence intensity, respectively. Total phenolic content was determined by the Folin Ciocalteau assay.

Author(s): 
Pérez-Cruz, Fernanda
Cortés, Contanza
Atala, Elias
Bohle, Pamela
Valenzuela, Francisco
Olea-Azar, Claudio
Speisky, Hernán
Aspée, Alexis
Lissi, Eduardo
López-Alarcón, Camilo
Bridi, Raquel

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