gamma-Linolenic Acid

Publication Title: 
PloS One

Borage (Borago officinalis L.) seed oil has been used as a treatment for various degenerative diseases. Many useful properties of this oil are attributed to its high gamma linolenic acid content (GLA, 18:3 ?-6). The purpose of this study was to demonstrate the safety and suitability of the use of borage seed oil, along with one of its active components, GLA, with respect to DNA integrity, and to establish possible in vivo toxic and in vitro cytotoxic effects.

Author(s): 
Tasset-Cuevas, Inmaculada
Fern·ndez-Bedmar, Zahira
Lozano-Baena, MarÌa Dolores
Campos-S·nchez, Juan
de Haro-BailÛn, Antonio
MuÒoz-Serrano, AndrÈs
Alonso-Moraga, Angeles
Publication Title: 
Rheumatology (Oxford, England)

OBJECTIVE: With the growing interest in herbal therapies among persons with rheumatoid arthritis, there exists a need for investigation into their safety and efficacy. The purpose of this study was to conduct a systematic review to examine the evidence for the use of herbal medicines for RA based on randomized clinical trials (RCTs). METHODS: A computerized search of eight electronic databases and the bibliographies of identified articles resulted in 14 studies meeting the inclusion criteria. Two raters independently extracted data and rated the trials for quality.

Author(s): 
Soeken, K. L.
Miller, S. A.
Ernst, E.
Publication Title: 
Clinical & Developmental Immunology

Dietary gammalinolenic acid (GLA), a potent inhibitor of 5-lipoxygenase (5-LOX) and suppressor of leukotriene B4 (LTB4), can attenuate the clinical course of rheumatoid arthritics, with negligible side effects. Since Zileuton, also an inhibitor of 5-LOX, attenuates asthma but with an undesirable side effect, we investigated whether dietary GLA would suppress biosynthesis of PMN-LTB4 isolated from asthma patients and attenuate asthma. Twenty-four mild-moderate asthma patients (16-75 years) were randomized to receive either 2.0 g daily GLA (borage oil) or corn oil (placebo) for 12 months.

Author(s): 
Ziboh, Vincent A.
Naguwa, Stanley
Vang, Kao
Wineinger, Julie
Morrissey, Brian M.
Watnik, Mitchell
Gershwin, M. Eric
Publication Title: 
The American Journal of Clinical Nutrition

Changes in diet over the past century have markedly altered the consumption of fatty acids. The dramatic increase in the ingestion of saturated and n-6 fatty acids and concomitant decrease in n-3 fatty acids are thought to be a major driver of the increase in the incidence of inflammatory diseases such as asthma, allergy, and atherosclerosis.

Author(s): 
Chilton, Floyd H.
Rudel, Lawrence L.
Parks, John S.
Arm, Jonathan P.
Seeds, Michael C.
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

Echium oil (EO) contains stearidonic acid (18:4), a n-3 polyunsaturated fatty acids (PUFAs), and gamma-linolenic acids (18:3), a n-6 PUFA that can be converted to long chain (LC)-PUFAs. We aimed to compare a safflower oil (SO)-enriched diet to EO- and fish oil (FO)-enriched diets on circulating and tissue PUFAs levels and glycemic, inflammatory, and cardiovascular health biomarkers in insulin resistant African green monkeys. In a Latin-square cross-over study, eight monkeys consumed matched diets for 6 weeks with 3-week washout periods.

Author(s): 
Kavanagh, K.
Flynn, D. M.
Jenkins, K. A.
Wilson, M. D.
Chilton, F. H.
Publication Title: 
Lipids in Health and Disease

BACKGROUND: Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) have been shown to impact PUFA metabolism, alter inflammatory processes including arachidonic acid (AA) metabolism and improve inflammatory disorders.

Author(s): 
Arm, Jonathan P.
Boyce, Joshua A.
Wang, Lin
Chhay, Heng
Zahid, Muhammad
Patil, Vaishali
Govindarajulu, Usha
Ivester, Priscilla
Weaver, Kelly L.
Sergeant, Susan
Israel, Elliot
Chilton, Floyd H.
Publication Title: 
JAMA

CONTEXT: The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury. OBJECTIVE: To determine if dietary supplementation of these substances to patients with acute lung injury would increase ventilator-free days to study day 28. DESIGN, SETTING, AND PARTICIPANTS: The OMEGA study, a randomized, double-blind, placebo-controlled, multicenter trial conducted from January 2, 2008, through February 21, 2009.

Author(s): 
Rice, Todd W.
Wheeler, Arthur P.
Thompson, B. Taylor
deBoisblanc, Bennett P.
Steingrub, Jay
Rock, Peter
NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators
NHLBI ARDS Clinical Trials Network
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