Ganglia, Spinal

Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

Spinal muscular atrophy (SMA), a recessive neurodegenerative disease, is characterized by the selective loss of spinal motor neurons. No available therapy exists for SMA, which represents one of the leading genetic causes of death in childhood. SMA is caused by a mutation of the survival-of-motor-neuron 1 (SMN1) gene, leading to a quantitative defect in the survival-motor-neuron (SMN) protein expression. All patients retain one or more copies of the SMN2 gene, which modulates the disease severity by producing a small amount of stable SMN protein.

Author(s): 
Branchu, Julien
Biondi, Olivier
Chali, Farah
Collin, Thibault
Leroy, Felix
Mamchaoui, Kamel
Makoukji, Joelle
Pariset, Claude
Lopes, Philippe
Massaad, Charbel
Chanoine, Christophe
Charbonnier, FrÈdÈric
Publication Title: 
Texas Dental Journal

Cervicogenic headache has historically been misdiagnosed, ultimately leading to misguided therapies. Even with the growing body of literature in the field of headache, this particular entity is still vastly understudied. Efforts should be made to encourage appropriate clinical studies in order to provide evidence based therapeutic modalities for this patient population. The dental professional is provided with the unique opportunity to see these patients on a regular basis without the time constraints now shouldered by our physician colleagues.

Author(s): 
Bender, Steven D.
Publication Title: 
Neuroscience

Women have greater temporal summation of experimental pain stimuli and also have a higher propensity for developing chronic visceral pain conditions. Sex hormone-mediated regulation of N-methyl-d-aspartic acid receptors (NMDARs) in nociceptive pathways is a plausible mechanism that may underlie these phenomena. The aim of this study was to compare the effect of 17-beta-estradiol (E2) in modulation of NMDAR activity in adult male and female rat dorsal root ganglia (DRG) neurons. DRG neurons were collected from adult male or female rats and grown in short-term culture in steroid-free media.

Author(s): 
McRoberts, J. A.
Li, J.
Ennes, H. S.
Mayer, E. A.
Publication Title: 
Neuroscience

The transient receptor potential vanilloid 1 receptor (TRPV1) is an important nociceptor involved in neurogenic inflammation. We aimed to examine the role of TRPV1 in experimental colitis and in the development of visceral hypersensitivity to mechanical and chemical stimulation. Male Sprague-Dawley rats received a single dose of trinitrobenzenesulfonic acid (TNBS) in the distal colon. In the preemptive group, rats received the TRPV1 receptor antagonist JYL1421 (10 mumol/kg, i.v.) or vehicle 15 min prior to TNBS followed by daily doses for 7 days.

Author(s): 
Miranda, A.
Nordstrom, E.
Mannem, A.
Smith, C.
Banerjee, B.
Sengupta, J. N.
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

An ideal therapeutic for stroke or spinal cord injury should promote survival and regeneration in the CNS. Arginase 1 (Arg1) has been shown to protect motor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins. To identify small molecules that capture Arg1's protective and regenerative properties, we screened a hippocampal cell line stably expressing the proximal promoter region of the arginase 1 gene fused to a reporter gene against a library of compounds containing clinically approved drugs.

Author(s): 
Ma, Thong C.
Campana, Aline
Lange, Philipp S.
Lee, Hsin-Hwa
Banerjee, Kasturi
Bryson, J. Barney
Mahishi, Lata
Alam, Shabnam
Giger, Roman J.
Barnes, Stephen
Morris, Sidney M.
Willis, Dianna E.
Twiss, Jeffrey L.
Filbin, Marie T.
Ratan, Rajiv R.
Publication Title: 
Pharmacological Research: The Official Journal of the Italian Pharmacological Society

Fish oil has been used to alleviate pain associated with inflammatory conditions such as rheumatoid arthritis. The anti-inflammatory property of fish oil is attributed to the n-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid. Contrarily, vegetable oils such as safflower oil are rich in n-6 fatty acids which are considered to be mediators of inflammation. This study investigates the effect of n-3 and n-6 fatty acids rich oils as dietary supplements on the thermally induced pain sensitivity in healthy mice.

Author(s): 
Veigas, Jyothi M.
Williams, Paul J.
Halade, Ganesh
Rahman, Mizanur M.
Yoneda, Toshiyuki
Fernandes, Gabriel
Publication Title: 
Cells, Tissues, Organs

Chronic musculoskeletal pain, including low back pain, is a worldwide debilitating condition; however, the mechanisms that underlie its development remain poorly understood. Pathological neuroplastic changes in the sensory innervation of connective tissue may contribute to the development of nonspecific chronic low back pain. Progress in understanding such potentially important abnormalities is hampered by limited knowledge of connective tissue's normal sensory innervation.

Author(s): 
Corey, Sarah M.
Vizzard, Margaret A.
Badger, Gary J.
Langevin, Helene M.
Publication Title: 
Molecular Pain

BACKGROUND: Diabetic neuropathy is a common neuropathy associated with paresthaesia and pain. The mechanisms underlying the painful conditions are not well understood. The aim of this study is to investigate the participation of purinergic P2X3 receptors in painful diabetic neuropathy. RESULTS: Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ). We showed that mechanical allodynia was induced two weeks after a STZ injection and lasted for at least another seven weeks.

Author(s): 
Xu, Guang-Yin
Li, Guangwen
Liu, Ningang
Huang, Li-Yen Mae
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Aconiti Brachypodi Radix, belonging to the genus of Aconitum (Family Ranunculaceae), are used clinically as anti-rheumatic, anti-inflammatory and anti-nociceptive in traditional medicine of China. However, its mechanism and influence on nociceptive threshold are unknown and need further investigation. The analgesic effects of ethanolic extract of Aconiti Brachypodi Radix (EABR) were thus studied in vivo and in vitro. Three pain models in mice were used to assess the effect of EABR on nociceptive threshold.

Author(s): 
Ren, Wei
Yuan, Lin
Li, Jun
Huang, Xian-Ju
Chen, Su
Zou, Da-Jiang
Liu, Xiangming
Yang, Xin-Zhou
Publication Title: 
Pharmacological Research: The Official Journal of the Italian Pharmacological Society

Fish oil has been used to alleviate pain associated with inflammatory conditions such as rheumatoid arthritis. The anti-inflammatory property of fish oil is attributed to the n-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid. Contrarily, vegetable oils such as safflower oil are rich in n-6 fatty acids which are considered to be mediators of inflammation. This study investigates the effect of n-3 and n-6 fatty acids rich oils as dietary supplements on the thermally induced pain sensitivity in healthy mice.

Author(s): 
Veigas, Jyothi M.
Williams, Paul J.
Halade, Ganesh
Rahman, Mizanur M.
Yoneda, Toshiyuki
Fernandes, Gabriel

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