Gastritis

Publication Title: 
Gastroenterology

BACKGROUND & AIMS: Helicobacter pylori-induced immune responses fail to eradicate the bacterium. Nitric oxide (NO) can kill H pylori. However, translation of inducible NO synthase (iNOS) and NO generation by H pylori-stimulated macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and is dependent on availability of the iNOS substrate L-arginine (L-Arg). We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages.

Author(s): 
Chaturvedi, Rupesh
Asim, Mohammad
Hoge, Svea
Lewis, Nuruddeen D.
Singh, Kshipra
Barry, Daniel P.
de Sablet, Thibaut
Piazuelo, M. Blanca
Sarvaria, Aditya R.
Cheng, Yulan
Closs, Ellen I.
Casero, Robert A.
Gobert, Alain P.
Wilson, Keith T.
Publication Title: 
PloS One

Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by antibiotic resistance. We reported that administration of 1% D,L-α-difluoromethylornithine (DFMO) to mice infected with H. pylori reduces gastritis and colonization, which we attributed to enhanced host immune response due to inhibition of macrophage ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.

Author(s): 
Barry, Daniel P.
Asim, Mohammad
Leiman, David A.
de Sablet, Thibaut
Singh, Kshipra
Casero, Robert A.
Chaturvedi, Rupesh
Wilson, Keith T.
Publication Title: 
PloS One

Once acquired, Helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. Our previous studies indicate that interactions among the various pathways of arginine metabolism in the host are critical determinants of outcomes following infection. Cationic amino acid transporter 2 (CAT2) is essential for transport of L-arginine (L-Arg) into monocytic immune cells during H. pylori infection.

Author(s): 
Barry, Daniel P.
Asim, Mohammad
Scull, Brooks P.
Piazuelo, M. Blanca
de Sablet, Thibaut
Lewis, Nuruddeen D.
Coburn, Lori A.
Singh, Kshipra
Ellies, Lesley G.
Gobert, Alain P.
Chaturvedi, Rupesh
Wilson, Keith T.
Publication Title: 
PloS One

Helicobacter pylori is the strongest known risk factor for the development of gastric adenocarcinoma. H. pylori expresses a repertoire of virulence factors that increase gastric cancer risk, including the cag pathogenicity island and the vacuolating cytotoxin (VacA). One host element that promotes carcinogenesis within the gastrointestinal tract is Krüppel-like factor 5 (KLF5), a transcription factor that mediates key cellular functions. To define the role of KLF5 within the context of H.

Author(s): 
Noto, Jennifer M.
Khizanishvili, Tinatin
Chaturvedi, Rupesh
Piazuelo, M. Blanca
Romero-Gallo, Judith
Delgado, Alberto G.
Khurana, Shradha S.
Sierra, Johanna C.
Krishna, Uma S.
Suarez, Giovanni
Powell, Anne E.
Goldenring, James R.
Coffey, Robert J.
Yang, Vincent W.
Correa, Pelayo
Mills, Jason C.
Wilson, Keith T.
Peek, Richard M.
Publication Title: 
PloS One

Accurate and high-throughput technologies are needed for identification of new therapeutic targets and for optimizing therapy in inflammatory bowel disease. Our aim was to assess multi-analyte protein-based assays of cytokines/chemokines using Luminex technology. We have reported that Luminex-based profiling was useful in assessing response to L-arginine therapy in the mouse model of dextran sulfate sodium colitis. Therefore, we studied prospectively collected samples from ulcerative colitis (UC) patients and control subjects.

Author(s): 
Coburn, Lori A.
Horst, Sara N.
Chaturvedi, Rupesh
Brown, Caroline T.
Allaman, Margaret M.
Scull, Brooks P.
Singh, Kshipra
Piazuelo, M. Blanca
Chitnavis, Maithili V.
Hodges, Mallary E.
Rosen, Michael J.
Williams, Christopher S.
Slaughter, James C.
Beaulieu, Dawn B.
Schwartz, David A.
Wilson, Keith T.
Publication Title: 
Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion
Author(s): 
Qu, Yu-Jiang
Xuan, Zhi-Jin
Publication Title: 
Chinese Medical Journal

BACKGROUND: Spleen in Traditional Chinese Medicine (TCM) is not actually the spleen in the anatomic sense designated in western medicine because its functions basically belong to the physiological category of digestive system in modern medicine, and it represents a macroscopic concept of digestion, absorption and nutrition metabolism. Spleen deficiency syndrome refers to the clinical phenomena such as hypofunction of digestion, absorption and nutrition metabolism.

Author(s): 
Yin, Guang-yao
Zhang, Wu-ning
Shen, Xiao-jing
He, Xue-fen
Chen, Yi
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: Chronic gastritis was treated with herbal pairs in order to reduce the side effects and raise the therapeutic effects. METHOD: The outpatients were randomly divided into a treatment group treated with herbal pairs and a control group treated with Banxia Xiexin Tang (Pinellia Decoction for Purging the Stomach-fire). RESULT: The total effective rate in the treatment group was 96%, higher than that in the control group (P < 0.05).

Author(s): 
Xia, Jianzhong
Publication Title: 
Chinese Medical Journal

BACKGROUND: Most of the studies on traditional Chinese medicine (TCM) 'spleen' deficiency syndrome in the recent 30 years were conducted only on the basis of single functional index, neglecting the study on the pathophysiologic internal relationship between spleen deficiency syndrome and gastric diseases in modern medicine. But it was at the subcellular molecular biological level that we explored the pathophysiologic basis of classification of spleen deficiency in chronic gastritis by detecting the bioactive substances in gastric mucosa nuclei and mitochondria.

Author(s): 
Yin, Guang-yao
Chen, Yi
Shen, Xiao-jing
He, Xue-fen
Zhang, Wu-ning
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To explore microcosmic information in chronic gastritis dampness syndrome by using serum proteomics of patients with chronic gastritis dampness syndrome. METHODS: Serum proteomics of 18 dampness syndrome cases, 17 non-dampness syndrome cases in chronic gastritis patients and 8 normal controls were analyzed by surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) protein-chip.

Author(s): 
Wang, Yi-Qin
Li, Fu-Feng
Wang, Wen-jing
Zhao, Li-yu
Guo, Li
Wang, Hui-fang

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