Gastrointestinal Motility

Publication Title: 
Alimentary Pharmacology & Therapeutics

Gastrointestinal dysmotility in systemic sclerosis (scleroderma) is prevalent in 90% of patients, increasing morbidity and in some cases mortality. The resultant gastrointestinal complications are usually extensive, involving many regions of the gut from the oesophagus to the anus. Collagen replacement of vascular and enteric smooth muscle results in hypomotility, lumen dilatation, tensile rigidity and eventual loss of organ functions. The aim of this paper is to provide an overview of systemic sclerosis-related gastrointestinal dysmotility and available/potential therapeutic options.

Author(s): 
Sallam, H.
McNearney, T. A.
Chen, J. D. Z.
Publication Title: 
Gut

Patients suffering from functional gastrointestinal disorders are likely to search elsewhere when conventional therapies fail them. Enthusiasm for complementary and alternative medicine use and research is clearly growing. Studies of acupuncture and herbal therapy for functional gastrointestinal disorders in the Western literature have often been limited by poor study design but these interventions may have promise and are discussed here.

Author(s): 
Tillisch, K.
Publication Title: 
The Journal of Veterinary Medical Science / the Japanese Society of Veterinary Science

Acupoints on the Large Intestine Meridian and specific acupoints related with large intestine have been empirically used to treat large intestinal disease. However, the relationship between acupoints related with large intestine and their functions has not been investigated fully. We investigated whether large intestine-related acupoints affect colonic motility in conscious dogs implanted with electrodes at the proximal colon. Manual acupuncture was applied at the following acupoints: 7 main points on the Large Intestine Meridian (LI1, LI2, LI3, LI4, LI5, LI6, and LI11), ST25, BL25 or GV1.

Author(s): 
Kim, Hee-Young
Hahm, Dae-Hyun
Pyun, Kwang-Ho
Lee, Hye-Jung
Nam, Tchi-Chou
Shim, Insop
Publication Title: 
World journal of gastroenterology: WJG

AIM: To investigate the effects and mechanisms of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in the modulation of electroacupucture (EA) on gastric motility in restrained-cold stressed rats. METHODS: An animal model of gastric motility disorder was established by restrained-cold stress. Gastric myoelectric activities were recorded by electrogastroenterography (EGG). VIP and NO concentrations in plasma and gastric mucosal and bulb tissues were detected by radioimmunoassay (RIA).

Author(s): 
Shen, Guo-Ming
Zhou, Mei-Qi
Xu, Guan-Sun
Xu, Ying
Yin, Gang
Publication Title: 
World journal of gastroenterology: WJG

AIM: To observe the effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow (GMBF), gastric motility and brain-gut peptide. METHODS: Sixty SD rats were randomly divided into 6 groups: normal control group, model group (group with gastric mucosal damage, GMD), Sibai group (with acupuncture at Sibai point + GMD), Tianshu group (with acupuncture at Tianshu point + GMD), Zusanli group (with acupuncture at Zusanli point + GMD) and non-acupoint group (with acupuncture at non-acupoint + GMD). The GMD model group was induced by infusing pure alcohol into gastric cavity.

Author(s): 
Lin, Ya-ping
Yi, Shou-Xiang
Yan, Jie
Chang, Xiao-rong
Publication Title: 
American Journal of Physiology. Gastrointestinal and Liver Physiology

Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes.

Author(s): 
Chen, Jie
Song, Geng-Qing
Yin, Jieyun
Koothan, Thillai
Chen, J. D. Z.
Publication Title: 
World journal of gastroenterology: WJG

AIM: To examine whether acupuncture can prevent prolonged postoperative ileus (PPOI) after intraperitoneal surgery for colon cancer. METHODS: Ninety patients were recruited from the Fudan University Cancer Hospital, Shanghai, China. After surgery, patients were randomized to receive acupuncture (once daily, starting on postoperative day 1, for up to six consecutive days) or usual care. PPOI was defined as an inability to pass flatus or have a bowel movement by 96 h after surgery. The main outcomes were time to first flatus, time to first bowel movement, and electrogastroenterography.

Author(s): 
Meng, Zhi-Qiang
Garcia, M. Kay
Chiang, Joseph S.
Peng, Hui-Ting
Shi, Ying-Qiang
Fu, Jie
Liu, Lu-Ming
Liao, Zhong-Xing
Zhang, Ying
Bei, Wen-Ying
Thornton, Bob
Palmer, J. Lynn
McQuade, Jennifer
Cohen, Lorenzo
Publication Title: 
American Journal of Physiology. Gastrointestinal and Liver Physiology

The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats.

Author(s): 
Yin, Jieyun
Chen, Jie
Chen, Jiande D. Z.
Publication Title: 
Autonomic Neuroscience: Basic & Clinical

During the last decades, numerous studies have been performed to investigate the effects and mechanisms of acupuncture or electroacupuncture (EA) on gastrointestinal motility and patients with functional gastrointestinal diseases. A PubMed search was performed on this topic and all available studies published in English have been reviewed and evaluated. This review is organized based on the gastrointestinal organ (from the esophagus to the colon), components of gastrointestinal motility and the functional diseases related to specific motility disorders.

Author(s): 
Yin, Jieyun
Chen, Jiande D. Z.
Publication Title: 
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

Background acupuncture (AP) has been shown to have a therapeutic potential for gastrointestinal motility disorders. The aims of this study were to investigate the effects and possible mechanisms of acupuncture on postprandial upper and lower abdominal symptoms induced by rectal distension (RD). Twenty healthy volunteers were involved in a two-session study (AP and sham-AP, AP and no-AP, or sham-AP and no-AP). In 12 of the volunteers, RD was performed for 60 min in the postprandial state, and AP at ST36 or sham-AP was performed during the second 30-min period of RD.

Author(s): 
Liu, Jinsong
Huang, Hong
Xu, Xiaohong
Chen, J. D. Z.

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