Gastrointestinal Transit

Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

BACKGROUND: Tri-sa-maw recipe is comprised ofequal proportions of three herbal fruits, including Terminalia chebula Retz., Terminalia sp. and Terminalia bellirica Roxb. The traditional use of this recipe has been reported as a medication for fever; expectorant, relief of tightness in the stomach, laxative and antidiarrheal agent. OBJECTIVE: To study the effects of Tri-sa-maw recipe extract on gastrointestinal tract in both in vitro and in vivo.

Author(s): 
Wannasiri, Supaporn
Jaijoy, Kanjana
Chiranthanut, Natthakarn
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Publication Title: 
Pharmaceutical Biology

Context Chebulae Fructus is used as an herbal remedy for diarrhoea in traditional Chinese medicine. However, there is no scientific evidence to support its antidiarrhoeal activity. Objective This study evaluates the antidiarrhoeal properties of Chebulae Fructus aqueous extract (CFAE) and determines the active fraction. Materials and methods The antidiarrhoeal effect of CFAE (200-800?mg/kg) was investigated by determining the wet dropping, intestinal transit in BALB/c mice and enteropooling in Wister rats.

Author(s): 
Sheng, Zunlai
Yan, Xin
Zhang, Ruili
Ni, Huilin
Cui, Yuanxu
Ge, Junwei
Shan, Anshan
Publication Title: 
Gut

The ability of hypnosis to modulate the orocaecal transit time of 10 g lactulose was tested in six healthy volunteers. Orocaecal transit time was measured by the hydrogen breath test during three periods in random order. During the control period the subjects remained throughout the test in a semirecumbent position without moving. During the hypnotic relaxation period subjects were hypnotised before lactulose ingestion and were instructed to experience relaxation till the orocaecal transit time had elapsed.

Author(s): 
Beaugerie, L.
Burger, A. J.
Cadranel, J. F.
Lamy, P.
Gendre, J. P.
Le Quintrec, Y.
Publication Title: 
Arzneimittel-Forschung

The general pharmacological properties of YJA 20379-1 (2-amino-4,5-dihydro-8-phenylimidazo[2,1-b]thiazolo[4,5-g]benzo thi azole), a novel proton pump inhibitor with antiulcer activities, were investigated in mice, rats, guinea pig and rabbits. YJA 20379-1 at oral doses of 50, 100 and 200 mg/kg did not affect the general behaviour, hexobarbital hypnosis, motor coordination and body temperature in mice. The drug does not have analgesic and anticonvulsant action at 200 mg/kg p.o. The locomotor activity was not affected at 100 mg/kg p.o., but at 200 mg/kg, the activity was suppressed.

Author(s): 
Lee, E. B.
Cho, S. I.
Cheon, S. A.
Chang, M. S.
Kim, K. B.
Sohn, S. K.
Chung, Y. K.
Publication Title: 
Journal of Ethnopharmacology

Preliminary pharmacological studies were performed on the methanol extract of Bixa orellana L. (Bixaceae) leaves to investigate neuropharmacological, anticonvulsant, analgesic, antidiarrhoeal activity and effect on gastrointestinal motility. All studies were conducted in mice using doses of 125, 250 and 500 mg/kg of body weight. In the pentobarbitone-induced hypnosis test, the extract statistically reduced the time for the onset of sleep at 500 mg/kg dose and (dose-dependently) increased the total sleeping time at 250 and 500 mg/kg dose.

Author(s): 
Shilpi, Jamil Ahmad
Taufiq-Ur-Rahman, Md
Uddin, Shaikh Jamal
Alam, Md Shahanur
Sadhu, Samir Kumar
Seidel, Véronique
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Paridis saponins (RPS) have been well studied for antimicrobial, anti-hemorrhagic, and anticancer effects. However, scientific information on RPS regarding the toxic and neuropharmacological effects is limited. In this study, the acute oral toxicity, sedative-hypnotic activity and gastro-intestinal toxicity of RPS were investigated. MATERIALS AND METHODS: The acute toxicity was carried out by administering single doses (800-5000 mg/kg) of RPS to adult mice.

Author(s): 
Liu, Zhen
Gao, Wenyuan
Man, Shuli
Wang, Jieyin
Li, Nan
Yin, Shuangshuang
Wu, Shanshan
Liu, Changxiao
Publication Title: 
Scandinavian Journal of Gastroenterology

BACKGROUND: Gut-directed hypnotherapy is an effective treatment in irritable bowel syndrome (IBS) but little is known about the mechanisms of action. In this study we aimed to investigate the effects on gastrointestinal motility when treating IBS with gut-directed hypnotherapy. METHODS: We randomized 90 patients with IBS, refractory to standard management to receive gut-directed hypnotherapy 1 h/week for 12 weeks or supportive treatment for the same time period.

Author(s): 
Lindfors, Perjohan
Törnblom, Hans
Sadik, Riadh
Björnsson, Einar S.
Abrahamsson, Hasse
Simrén, Magnus
Publication Title: 
British Journal of Pharmacology

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride.

Author(s): 
Borrelli, Francesca
Capasso, Francesco
Capasso, Raffaele
Ascione, Valeria
Aviello, Gabriella
Longo, Rocco
Izzo, Angelo A.
Publication Title: 
British Journal of Pharmacology

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride.

Author(s): 
Borrelli, Francesca
Capasso, Francesco
Capasso, Raffaele
Ascione, Valeria
Aviello, Gabriella
Longo, Rocco
Izzo, Angelo A.
Publication Title: 
Journal of Herbal Pharmacotherapy

The anti-diarrhoeal effect of aqueous and alcoholic extracts of Triphala and Triphala Mashi were studied employing castor oil-induced-diarrhoeal model in rats. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. All the extracts, at various doses 200, 400 and 800 mg/kg displayed remarkable anti-diarrhoeal activity as evidenced by a significant increase in first defecation time, cumulative fecal weight and intestinal transit time.

Author(s): 
Biradar, Y. S.
Singh, R.
Sharma, K.
Dhalwal, K.
Bodhankar, S. L.
Khandelwal, K. R.

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