Gene Library

Publication Title: 
BMJ clinical evidence

INTRODUCTION: Chronic tension-type headache (CTTH) is a disorder that evolves from episodic tension-type headache, with daily or very frequent episodes of headache lasting minutes to days. It affects 4.1% of the general population in the USA, and is more prevalent in women (up to 65% of cases). METHODS AND OBJECTIVES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug treatments for chronic tension-type headache? What are the effects of non-drug treatments for chronic tension-type headache?

Author(s): 
Silver, Nicholas
Publication Title: 
BMJ clinical evidence

INTRODUCTION: Chronic tension-type headache (CTTH) is a disorder that evolves from episodic tension-type headache, with daily or very frequent episodes of headache lasting minutes to days. It affects 4.1% of the general population in the USA, and is more prevalent in women (up to 65% of cases). METHODS AND OBJECTIVES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug treatments for chronic tension-type headache? What are the effects of non-drug treatments for chronic tension-type headache?

Author(s): 
Silver, Nicholas
Publication Title: 
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

The Ma gene for root-knot nematode (RKN)resistance from Myrobalan plum (Prunus cerasifera L.)confers a complete-spectrum and a heat-stable resistance to Meloidogvne spp., conversely to Mi-I from tomato,which has a more restricted spectrum and a reduced efficiency at high temperature. This gene was identified from a perennial self-incompatible near-wild rootstock species and lies in cosegregation with the SCAR marker SCAFLP2 on the Prunus linkage group 7 in a 2.3 cM interval between the SCAR SCAL19 and SSR pchgms6 markers.

Author(s): 
Claverie, M.
Dirlewanger, E.
Cosson, P.
Bosselut, N.
Lecouls, A. C.
Voisin, R.
Kleinhentz, M.
Lafargue, B.
Caboche, M.
Chalhoub, B.
Esmenjaud, D.
Publication Title: 
Molecular Psychiatry

Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals. Little is known about human A-to-I editing, but it is thought to constitute one of many molecular mechanisms connecting environmental stimuli and behavioral outputs. Thus, comprehensive exploration of A-to-I RNA editing in human brains may shed light on gene-environment interactions underlying complex behavior in health and disease.

Author(s): 
Eran, A.
Li, J. B.
Vatalaro, K.
McCarthy, J.
Rahimov, F.
Collins, C.
Markianos, K.
Margulies, D. M.
Brown, E. N.
Calvo, S. E.
Kohane, I. S.
Kunkel, L. M.
Publication Title: 
Experimental Neurology

A hexanucleotide repeat expansion residing within the C9ORF72 gene represents the most common known cause of amyotrophic lateral sclerosis (ALS) and places the disease among a growing family of repeat expansion disorders. The presence of RNA foci, repeat-associated translation products, and sequestration of RNA binding proteins suggests that toxic RNA gain-of-function contributes to pathology while C9ORF72 haploinsufficiency may be an additional pathological factor.

Author(s): 
Zeier, Zane
Esanov, Rustam
Belle, Kinsley C.
Volmar, Claude-Henry
Johnstone, Andrea L.
Halley, Paul
DeRosa, Brooke A.
Khoury, Nathalie
van Blitterswijk, Marka
Rademakers, Rosa
Albert, Jeffrey
Brothers, Shaun P.
Wuu, Joanne
Dykxhoorn, Derek M.
Benatar, Michael
Wahlestedt, Claes
Publication Title: 
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

OBJECTIVE: To explore a method for rapid construction of a full-length cDNA library of human glioma tissues using switching mechanism at 5' end of RNA transcript (SMART). METHODS: The total RNA was extracted from several samples of human glioma tissues and the mRNA was subsequently separated. Multiple mRNA samples were mixed to be used as the template for the first-strand cDNA synthesis.

Author(s): 
Tu, Yan-yang
Xu, Ru-xiang
Yang, Zhi-lin
Jiang, Xiao-dan
Wu, Shu-guang
Chen, Yi-zhao
Cai, Ying-qian
Du, Mou-xuan
Gao, Yang
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine (polyQ) expansion in the protein huntingtin (htt). Pathogenesis in HD seems to involve the formation of neuronal intranuclear inclusions and the abnormal regulation of transcription and signal transduction. To identify previously uncharacterized htt-interacting proteins in a simple model system, we used a yeast two-hybrid screen with a Caenorhabditis elegans activation domain library. We found a predicted SH3 domain protein (K08E3.3b) that interacts with N-terminal htt in two-hybrid tests.

Author(s): 
Holbert, Sébastien
Dedeoglu, Alpaslan
Humbert, Sandrine
Saudou, Frédéric
Ferrante, Robert J.
Neri, Christian
Publication Title: 
The Journal of Biological Chemistry

Galectins constitute a family of proteins that bind to beta-galactoside residues and have diverse physiological functions. Here we report on the identification of a galectin-like molecule, galectin-12, in a human adipose tissue cDNA library. The protein contained two potential carbohydrate-recognition domains with the second carbohydrate-recognition domain being less conserved compared with other galectins. In vitro translated galectin-12 bound to a lactosyl-agarose column far less efficiently than galectin-8.

Author(s): 
Hotta, K.
Funahashi, T.
Matsukawa, Y.
Takahashi, M.
Nishizawa, H.
Kishida, K.
Matsuda, M.
Kuriyama, H.
Kihara, S.
Nakamura, T.
Tochino, Y.
Bodkin, N. L.
Hansen, B. C.
Matsuzawa, Y.
Publication Title: 
BMC genomics

BACKGROUND: Siraitia grosvenorii (Luohanguo) is an herbaceous perennial plant native to southern China and most prevalent in Guilin city. Its fruit contains a sweet, fleshy, edible pulp that is widely used in traditional Chinese medicine. The major bioactive constituents in the fruit extract are the cucurbitane-type triterpene saponins known as mogrosides. Among them, mogroside V is nearly 300 times sweeter than sucrose. However, little is known about mogrosides biosynthesis in S. grosvenorii, especially the late steps of the pathway.

Author(s): 
Tang, Qi
Ma, Xiaojun
Mo, Changming
Wilson, Iain W.
Song, Cai
Zhao, Huan
Yang, Yanfang
Fu, Wei
Qiu, Deyou
Publication Title: 
PloS One

Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects. In addition to being a potent acetylcholinesterase inhibitor, it was thought to act through other mechanisms such as antioxidation, antiapoptosis, etc. However, the molecular targets involved with these mechanisms were not identified. In this study, we attempted to exam the interactome of Huperzine A using a cDNA phage display library and also mammalian brain tissue extracts.

Author(s): 
Guo, Wei
Liu, Shupeng
Peng, Jinliang
Wei, Xiaohui
Sun, Ye
Qiu, Yangsheng
Gao, Guangwei
Wang, Peng
Xu, Yuhong

Pages

Subscribe to RSS - Gene Library