Genome-Wide Association Study

Publication Title: 
L‰kartidningen
Author(s): 
Viidik, Andrus
Publication Title: 
Rejuvenation Research

Long-living individuals (LLIs) are used to study exceptional longevity. A number of genetic variants have been found associated in LLIs to date, but further identification of variants would improve knowledge on the mechanisms regulating the rate of aging. Therefore, we performed a genome-wide association study on 410 LLIs and 553 young control individuals with a 317K single-nucleotide polymorphism (SNP) chip to identify novel traits associated with aging.

Author(s): 
Malovini, Alberto
Illario, Maddalena
Iaccarino, Guido
Villa, Francesco
Ferrario, Anna
Roncarati, Roberta
Anselmi, Chiara Viviani
Novelli, Valeria
Cipolletta, Ersilia
Leggiero, Eleonora
Orro, Alessandro
Rusciano, Maria Rosaria
Milanesi, Luciano
Maione, Angela Serena
Condorelli, Gianluigi
Bellazzi, Riccardo
Puca, Annibale A.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet the identification of the underlying genes remains a challenge. Longevity is a complex phenotype with modest heritability. Age-related phenotypes with higher heritability may have greater success in gene discovery. Candidate gene and genome-wide association studies (GWAS) for longevity have had only limited success to date.

Author(s): 
Murabito, Joanne M.
Yuan, Rong
Lunetta, Kathryn L.
Publication Title: 
PloS One

BACKGROUND: Although there is abundant evidence that human longevity is heritable, efforts to map loci responsible for variation in human lifespan have had limited success. METHODOLOGY/PRINCIPAL FINDINGS: We identified individuals from a large multigenerational population database (the Utah Population Database) who exhibited high levels of both familial longevity and individual longevity. This selection identified 325 related "affected individuals", defined as those in the top quartile for both excess longevity (EL?

Author(s): 
Kerber, Richard A.
O'Brien, Elizabeth
Boucher, Kenneth M.
Smith, Ken R.
Cawthon, Richard M.
Publication Title: 
Aging

Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, but as a group in specific combinations of genetic variations, they can have a strong influence.

Author(s): 
Sebastiani, Paola
Bae, Harold
Sun, Fangui X.
Andersen, Stacy L.
Daw, E. Warwick
Malovini, Alberto
Kojima, Toshio
Hirose, Nobuyoshi
Schupf, Nicole
Puca, Annibale
Perls, Thomas T.
Publication Title: 
Metabolism: Clinical and Experimental

OBJECTIVE: Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark.

Author(s): 
An, Ping
Miljkovic, Iva
Thyagarajan, Bharat
Kraja, Aldi T.
Daw, E. Warwick
Pankow, James S.
Selvin, Elizabeth
Kao, W. H. Linda
Maruthur, Nisa M.
Nalls, Micahel A.
Liu, Yongmei
Harris, Tamara B.
Lee, Joseph H.
Borecki, Ingrid B.
Christensen, Kaare
Eckfeldt, John H.
Mayeux, Richard
Perls, Thomas T.
Newman, Anne B.
Province, Michael A.
Publication Title: 
PloS One

BACKGROUND: Although there is abundant evidence that human longevity is heritable, efforts to map loci responsible for variation in human lifespan have had limited success. METHODOLOGY/PRINCIPAL FINDINGS: We identified individuals from a large multigenerational population database (the Utah Population Database) who exhibited high levels of both familial longevity and individual longevity. This selection identified 325 related "affected individuals", defined as those in the top quartile for both excess longevity (EL?

Author(s): 
Kerber, Richard A.
O'Brien, Elizabeth
Boucher, Kenneth M.
Smith, Ken R.
Cawthon, Richard M.
Publication Title: 
PLoS genetics

Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association between whole-blood DNA methylation patterns in 172 female twins aged 32 to 80 with age and age-related phenotypes.

Author(s): 
Bell, Jordana T.
Tsai, Pei-Chien
Yang, Tsun-Po
Pidsley, Ruth
Nisbet, James
Glass, Daniel
Mangino, Massimo
Zhai, Guangju
Zhang, Feng
Valdes, Ana
Shin, So-Youn
Dempster, Emma L.
Murray, Robin M.
Grundberg, Elin
Hedman, Asa K.
Nica, Alexandra
Small, Kerrin S.
MuTHER Consortium
Dermitzakis, Emmanouil T.
McCarthy, Mark I.
Mill, Jonathan
Spector, Tim D.
Deloukas, Panos
Publication Title: 
PLoS pathogens

Removal of the reproductive system of many animals including fish, flies, nematodes, mice and humans can increase lifespan through mechanisms largely unknown. The abrogation of the germline in Caenorhabditis elegans increases longevity by 60% due to a signal emitted from the somatic gonad. Apart from increased longevity, germline-less C. elegans is also resistant to other environmental stressors such as feeding on bacterial pathogens.

Author(s): 
Rae, Robbie
Sinha, Amit
Sommer, Ralf J.
Publication Title: 
Aging Cell

Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project.

Author(s): 
Beekman, Marian
BlanchÈ, HÈlËne
Perola, Markus
Hervonen, Anti
Bezrukov, Vladyslav
Sikora, Ewa
Flachsbart, Friederike
Christiansen, Lene
de Craen, Anton J. M.
Kirkwood, Tom B. L.
Rea, Irene Maeve
Poulain, Michel
Robine, Jean-Marie
Valensin, Silvana
Stazi, Maria Antonietta
Passarino, Giuseppe
Deiana, Luca
Gonos, Efstathios S.
Paternoster, Lavinia
S¯rensen, Thorkild I. A.
Tan, Qihua
Helmer, Quinta
van den Akker, Erik B.
Deelen, Joris
Martella, Francesca
Cordell, Heather J.
Ayers, Kristin L.
Vaupel, James W.
Tˆrnwall, Outi
Johnson, Thomas E.
Schreiber, Stefan
Lathrop, Mark
Skytthe, Axel
Westendorp, Rudi G. J.
Christensen, Kaare
Gampe, Jutta
Nebel, Almut
Houwing-Duistermaat, Jeanine J.
Slagboom, Pieternella Eline
Franceschi, Claudio
GEHA consortium

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