Geriatric Assessment

Publication Title: 
Geriatrics & Gerontology International

Medication adherence is a crucial part in the management of chronic diseases. As older adults form a greater proportion of the population with chronic diseases and multiple morbidities, understanding medication adherence in older adults becomes important. In the present article, we aimed to systematically review the literature for the factors associated with medication adherence in the geriatric population. We carried out a literature search using electronic databases and related keywords. 17?391 articles were reviewed in total. 65 articles were found to be relevant to our objective.

Yap, Angela Frances
Thirumoorthy, Thiru
Kwan, Yu Heng
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%.

Karasik, David
Demissie, Serkalem
Cupples, L. Adrienne
Kiel, Douglas P.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Centenarians are sometimes said to be representative of lifelong healthy aging. Whether they are, in fact, examples of healthy aging remains a subject of debate. The existence of heterogeneity in functional status has been reported repeatedly in previous studies of centenarians. However, there is as yet no standardized classification system with which to describe their functional phenotype. METHODS: As part of a dynamic cohort study, we studied 304 centenarians (65 men and 239 women) living in Tokyo.

Gondo, Yasuyuki
Hirose, Nobuyoshi
Arai, Yasumichi
Inagaki, Hiroki
Masui, Yukie
Yamamura, Ken
Shimizu, Ken-ichirou
Takayama, Michiyo
Ebihara, Yoshinori
Nakazawa, Susumu
Kitagawa, Koji
Publication Title: 

As the elderly population is increasing rapidly, there is a lot of scientific interest in clarifying the differential life-style, genetic, biochemical and molecular factors contributing to mortality or exceptional longevity. Within the framework of the ZINCAGE project, 249 old (60-85 years) and nonagenarian Greek subjects (>/=85 years old) were recruited and anthropometrical, blood and biochemical indices as well as blood pressure measurements were obtained.

Kanoni, Stavroula
Dedoussis, George
Manios, Yannis
Malavolta, Marco
Mocchegiani, Eugenio
Publication Title: 
Archives of Gerontology and Geriatrics

The present study aims at describing the health status of a sample of relatively functional and healthy Greek centenarians and at exploring the potential gender differences in health in this sample. Its objectives are to add to the accumulation of knowledge about the health status of centenarians and therefore to contribute to the exploration of the mechanisms of healthy longevity. The study employs a non-representative community sample of Greek centenarians of both sexes (N=47).

Darviri, Christina
Demakakos, Panayotes
Charizani, Fotini
Tigani, Xanthi
Tsiou, Chrysoula
Chalamandaris, Alexandros G.
Tsagkari, Christina
Chliaoutakis, Joannnes
Publication Title: 
American Journal of Public Health

OBJECTIVES: We investigated the characteristics of the oldest old in China and examined whether the factors associated with longevity varied with advanced age. METHODS: Drawing from the largest nationally representative longitudinal sample of oldest-old adults, we stratified descriptive statistics separately by gender and urban-rural residence and then used ordered logit models to examine the multivariate factors associated with increasing age-group membership.

Dupre, Matthew E.
Liu, Guangya
Gu, Danan
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To characterize the social characteristics and physical, functional, mental, and cognitive health of exceptional survivors in the United States and how the experience of exceptional longevity differs according to social status. DESIGN: Nationally representative longitudinal study of older Americans. SETTING: United States. PARTICIPANTS: One thousand six hundred forty-nine men and women born from 1900 to 1911 from the Health and Retirement Study: 1,424 nonsurvivors who died before reaching the age of 97 and 225 exceptional survivors who survived to age 97 and older.

Ailshire, Jennifer A.
Beltr·n-S·nchez, Hiram
Crimmins, Eileen M.
Publication Title: 

Interdisciplinary study of telomere length, polymorphism of genes of renin-angiotensin (ACE) and serotonin (5HTR2A and 5HTTPR) systems in population of aged and old inhabitants of the North-West of Russia was conducted, in their relations to data from clinical and geriatric anamnesis, and psychological functioning. Regular link between telomere length and respondent's age was demonstrated in subgroups of old respondents and long-livers, by method of factor analysis.

Smirnova, T. Iu
Runov, A. L.
Vonski?, M. S.
Spivak, D. L.
Zakharchuk, A. G.
Mikhel'son, V. M.
Spivak, I. M.
Publication Title: 

Nitric oxide (NO) triggers multiple signal transduction pathways and contributes to the control of numerous cellular functions. Previous studies have shown in model organisms that the alteration of NO production has important effects on aging and lifespan. We studied in a large sample (763 subjects, age range 19-107†years) the variability of the three human genes (NOS1, -2, -3) coding for the three isoforms of the NADPH-dependent enzymes named NO synthases (NOS) which are responsible of NO synthesis.

Montesanto, Alberto
Crocco, Paolina
Tallaro, Federica
Pisani, Francesca
Mazzei, Bruno
Mari, Vincenzo
Corsonello, Andrea
Lattanzio, Fabrizia
Passarino, Giuseppe
Rose, Giuseppina
Publication Title: 

Despite great interest in the role of lipids in overall and disease-free survival, virtually no information is available on the lipids, lipoproteins and apolipoproteins of persons over 90 years of age. Furthermore, the genetic underpinnings of atherosclerosis and the particular genetic factors responsible for protection against coronary artery disease remain speculative.

Thieszen, S. L.
Hixson, J. E.
Nagengast, D. J.
Wilson, J. E.
McManus, B. M.


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