Publication Title: 
Journal of thrombosis and haemostasis: JTH

BACKGROUND: Thromboprophylaxis with rivaroxaban (R) is superior to enoxaparin in patients undergoing major orthopedic surgery (MOS). However, rivaroxaban has never been directly compared with fondaparinux (F), which also shows superior efficacy over enoxaparin. The clinical impact of switching from fondaparinux to rivaroxaban thromboprophylaxis is unclear. OBJECTIVES: To evaluate the efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in unselected patients undergoing MOS.

Beyer-Westendorf, J.
L¸tzner, J.
Donath, L.
Radke, O. C.
Kuhlisch, E.
Hartmann, A.
Weiss, N.
Werth, S.
Publication Title: 
Epidemiology (Cambridge, Mass.)
McMichael, A. J.
Publication Title: 
Epidemiology (Cambridge, Mass.)
Margetts, B. M.
Jackson, A. A.
Publication Title: 
European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology

The level of epigenetic DNA methylation is an important factor in the pathogenesis of various human diseases. As smoking may influence DNA methylation, we investigated the effect of smoking habits on global DNA methylation in 298 genomic DNA samples (73 fathers, 69 mothers and 156 offspring). We did not find a direct effect of smoking on global DNA methylation.

Hillemacher, Thomas
Frieling, Helge
Moskau, Susanna
Muschler, Marc A. N.
Semmler, Alexander
Kornhuber, Johannes
Klockgether, Thomas
Bleich, Stefan
Linnebank, Michael
Publication Title: 
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

Obesity is a relevant medical problem. Around 60?% of German adults are overweight, 20?% are obese. The hereditary contribution to the variance of body weight is high. Nevertheless, molecular genetic studies have as yet explained only a small part of the inter-individual variability in the body mass index (BMI). Monogenic forms of obesity, in which loss of a single gene product leads to extreme obesity, are very infrequent. Variance of body weight is commonly explained by a complex interplay of many genetic variants (polygenic obesity).

Hinney, A.
Herrfurth, N.
Schonnop, L.
Volckmar, A.-L.
Publication Title: 
Psychiatria Danubina

Posttraumatic Stress Disorder (PTSD) is a major health problem in South Eastern Europe (SEE). Available treatment options are not efficient enough and the course is often chronic. Little is known about molecular mediators and moderators of pathogenesis and therapy. Genetic and epigenetic variation may be one central molecular mechanism.

Kulenovic, Alma Dzubur
Agani, Ferid
Avdibegovic, Esmina
Jakovljevic, Miro
Babic, Dragan
Kucukalic, Abdulah
Kucukalic, Sabina
Dzananovic, Emina Sabic
Mehmedbasic, Alma Bravo
Uka, Aferdita Goci
Haxhibeqiri, Shpend
Haxhibeqiri, Valdete
Hoxha, Blerina
Sinanovic, Osman
Kravic, Nermina
Muminovic, Mirnesa
Aukst-Margetic, Branka
Jaksic, Nenad
Franc, Ana Cima
Rudan, Dusko
Pavlovic, Marko
Babic, Romana
Bojic, Elma Feric
Marjanovic, Damir
Bozina, Nada
Ziegler, Christiane
Wolf, Christiane
Warrings, Bodo
Domschke, Katharina
Deckert, J¸rgen
Publication Title: 

In 1919, Michael Fischer OSC was appointed to the German charity union "Zentrale des Deutschen Caritasverbandes" (DCV) in Freiburg. He assumed his duties as the acting manager and general secretary for the German catholic union of health institutions "Verband Katholischer Kranken- und Pflegeanstalten". For nearly twenty years, he was involved in expanding and strengthening this specialized organisation.

Kolling, H.
Publication Title: 
Christian Bioethics

The author comments on the consensus statement from the point of view of an ethics consultant in Germany. Since many hospitals in Germany are under considerable competitive pressure, mission statements are becoming more and more important in order to draw a distinction between the different hospital types and to convey the meaning of the corporate identity both internally and externally. The Consensus Statement, which provides basic orientation without going into too much detail, can be a helpful initial document.

Schmidt, K. W.
Publication Title: 
Der Urologe. Ausg. A

The growth of the city's population, rapid advances in medical science, the increasing understanding of the importance of hygiene and, finally, the demand for health care led to the erection of a modern 353-bed municipal hospital complex at Pommerensdorf, Apfelallee, which was officially opened in 1879. From the very beginning of its existence, the municipal hospital was constantly in the process of extension and rebuilding. A hospital base was set up and new departments and clinics were opened. In 1937, the number of the hospital beds had increased to 1,004.

Zajaczkowski, T.
Wojewski-Zajaczkowski, E. M.
Publication Title: 
Medizinhistorisches Journal

Next to the late Heinrich Schipperges, Gundolf Keil, M.D. and Ph.D. (Medieval German), ranks as one of the foremost German medical historians of the Western Middle Ages. Among his lasting merits is the publication of the MS Bamb. med. 1, called by him Lorscher Arzneibuch (Lorsch Medical Manual), which was written during the first years of the 9th century in the abbey of Lorsch (near Worms). Keil maintained that this work was not only the first medical book copied in the German-speaking area but that it was also drawn up in Lorsch and contained e.g.

Fischer, Klaus-Dietrich


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