Publication Title: 
Microscopy Research and Technique

Many hormonal signals from peripheral tissues contribute to the regulation of energy homeostasis and food intake. These regulators including leptin, insulin, and ghrelin, modulate the orexigenic and anorexigenic neuropeptide expression in hypothalamic nuclei. The anti-aging effects of caloric restriction have been explained from an evolutional viewpoint of the adaptive response of the neuroendocrine and metabolic response systems to maximize survival during periods of food shortage.

Chiba, Takuya
Yamaza, Haruyoshi
Higami, Yoshikazu
Shimokawa, Isao
Publication Title: 
Science (New York, N.Y.)
Marx, Jean
Publication Title: 
Spinney, Laura
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Despite the fact that growth hormone (GH) has not been approved for antiaging purposes, its use for this indication is widespread and increasing. The Growth Hormone Research Society (GRS) convened an international workshop to critically review and debate the available evidence related to the use of GH in the older adults and the relationship between the GH/insulin-like growth factor I (IGF-I) axis and the aging process.

Thorner, Michael O.
Publication Title: 
Aging Clinical and Experimental Research

BACKGROUND AND AIMS: Caloric restriction (CR) is the most robust and reproducible intervention for slowing aging, and maintaining health and vitality in animals. Previous studies found that CR is associated with changes in specific biomarkers in monkeys that were also associated with reduced risk of mortality in healthy men. In this study we examine the association between other potential biomarkers related to CR and extended lifespan in healthy humans.

Stenholm, Sari
Metter, E. Jeffrey
Roth, George S.
Ingram, Donald K.
Mattison, Julie A.
Taub, Dennis D.
Ferrucci, Luigi
Publication Title: 
Metabolism: Clinical and Experimental

Diets that are high in dietary fiber are reported to have substantial health benefits. We sought to compare the metabolic effects of 3 types of dietary fibers -- sugarcane fiber (SCF), psyllium (PSY), and cellulose (CEL) -- on body weight, carbohydrate metabolism, and stomach ghrelin gene expression in a high-fat diet-fed mouse model. Thirty-six male mice (C57BL/6) were randomly divided into 4 groups that consumed high-fat diet alone (HFD) or high-fat diet containing 10% SCF, PSY, and CEL, respectively.

Wang, Zhong Q.
Zuberi, Aamir R.
Zhang, Xian H.
Macgowan, Jacalyn
Qin, Jianhua
Ye, Xin
Son, Leslie
Wu, Qinglin
Lian, Kun
Cefalu, William T.
Publication Title: 
European Journal of Endocrinology / European Federation of Endocrine Societies

OBJECTIVE: Body composition and energy homeostasis are thought to affect the appetitive hormones: adiponectin, leptin, insulin, and ghrelin. This study examined whether centrally located fat and/or overall adiposity were related to these appetitive hormones in healthy postmenopausal women. DESIGN: Overall and regional body composition was assessed by dual-energy X ray absorptiometry in relation to plasma adiponectin, serum leptin, serum insulin, and plasma ghrelin in 242 postmenopausal women.

Ritland, Laura M.
Alekel, D. Lee
Matvienko, Oksana A.
Hanson, Kathy B.
Stewart, Jeanne W.
Hanson, Laura N.
Reddy, Manju B.
Van Loan, Marta D.
Genschel, Ulrike
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: We have reported that, compared with glucose-sweetened beverages, consuming fructose-sweetened beverages with meals results in lower 24-h circulating glucose, insulin, and leptin concentrations and elevated triacylglycerol (TG). However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States. OBJECTIVE: We compared the metabolic/endocrine effects of HFCS with sucrose and, in a subset of subjects, with pure fructose and glucose.

Stanhope, Kimber L.
Griffen, Steven C.
Bair, Brandi R.
Swarbrick, Michael M.
Keim, Nancy L.
Havel, Peter J.
Publication Title: 

Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulating ghrelin levels, and gastric emptying of a nonnutrient meal.

Stengel, Andreas
Goebel, Miriam
Million, Mulugeta
Stenzel-Poore, Mary P.
Kobelt, Peter
Mönnikes, Hubert
Taché, Yvette
Wang, Lixin
Publication Title: 
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

The prevalence of type 2 diabetes (T2DM) is increasing, creating a need for T2DM animal models for the study of disease pathogenesis, prevention, and treatment. The purpose of this project was to develop a rat model of T2DM that more closely models the pathophysiology of T2DM in humans. The model was created by crossing obese Sprague-Dawley rats with insulin resistance resulting from polygenic adult-onset obesity with Zucker diabetic fatty-lean rats that have a defect in pancreatic beta-cell function but normal leptin signaling.

Cummings, Bethany P.
Digitale, Erin K.
Stanhope, Kimber L.
Graham, James L.
Baskin, Denis G.
Reed, Benjamin J.
Sweet, Ian R.
Griffen, Steven C.
Havel, Peter J.


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