Glomerular Filtration Rate

Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To test whether lower serum uric acid (UA) levels are associated with longevity independent of renal function. DESIGN: Cross-sectional cohort study. SETTING: Ashkenazi Jewish individuals with exceptional longevity (Longevity Genes Project at Albert Einstein College of Medicine). PARTICIPANTS: Long-lived individuals (LLI) of Ashkenazi Jewish ethnicity (mean age ± standard deviation 97.7 ± 2.9, n = 365), their offspring (mean age ± standard deviation 68.2 ± 8.2, n = 593) and controls (without family history of longevity, mean age ± standard deviation 72.5 ± 9.9, n = 356).

Author(s): 
Lai, Jennifer Yi-Chun
Atzmon, Gil
Melamed, Michal L.
Hostetter, Thomas H.
Crandall, Jill P.
Barzilai, Nir
Bitzer, Markus
Publication Title: 
Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association

BACKGROUND: Chronic kidney disease (CKD) seems to be common in long-term survivors of haematopoietic cell transplantation (HCT). However, the range of its frequency is very wide, likely due to variability in the definitions of CKD and the periods of follow-up. METHODS: We conducted a cross-sectional and retrospective study in 158 adults who received myeloablative allogeneic HCT for lymphohaematologic malignancies at least 3 years ago and are alive today. The mean survival time was 6.15 +/- 4.88 years (range: 3-16 years).

Author(s): 
Ando, Minoru
Ohashi, Kazuteru
Akiyama, Hideki
Sakamaki, Hisashi
Morito, Taku
Tsuchiya, Ken
Nitta, Kosaku
Publication Title: 
The Journal of Thoracic and Cardiovascular Surgery

OBJECTIVE: With the increasing longevity of heart transplant recipients, the long-term effects of cyclosporine on renal function have become more evident. Highly sensitive, early, and effective monitoring of posttransplant renal function is still being researched. This study aimed to evaluate the prognostic value of cystatin C for patients after heart transplantation. METHODS: Seventy-three long-term recipients of a heart transplant more than 5 years before the study start were included in the analysis with a follow-up of 4 years.

Author(s): 
Kniepeiss, Daniela
Wagner, Doris
Wirnsberger, Gerhard
Roller, Regina E.
Wasler, Andr‰
Iberer, Florian
Tscheliessnigg, Karl-Heinz
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To test whether lower serum uric acid (UA) levels are associated with longevity independent of renal function. DESIGN: Cross-sectional cohort study. SETTING: Ashkenazi Jewish individuals with exceptional longevity (Longevity Genes Project at Albert Einstein College of Medicine). PARTICIPANTS: Long-lived individuals (LLI) of Ashkenazi Jewish ethnicity (mean age ± standard deviation 97.7 ± 2.9, n = 365), their offspring (mean age ± standard deviation 68.2 ± 8.2, n = 593) and controls (without family history of longevity, mean age ± standard deviation 72.5 ± 9.9, n = 356).

Author(s): 
Lai, Jennifer Yi-Chun
Atzmon, Gil
Melamed, Michal L.
Hostetter, Thomas H.
Crandall, Jill P.
Barzilai, Nir
Bitzer, Markus
Publication Title: 
British Medical Journal
Author(s): 
Preston, F. E.
Malia, R. G.
Blackburn, E. K.
Platts, M.
Publication Title: 
American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation

There is a desperate need for kidney donors. Twenty-five years ago, we urged more widespread acceptance of unrelated living donors for kidney transplantation. Since then, 2 of us have donated a kidney to an unrelated recipient. In our view, the major challenges for living donor transplantation today are to improve access to this extraordinary gift of life and ensure its safety.

Author(s): 
Levey, Andrew S.
Danovitch, Gabriel
Hou, Susan
Publication Title: 
Kidney International

BACKGROUND: Sodium artesunate is currently used in malaria treatment. Adverse effects of this drug have not been described, probably because they cannot be differentiated from malaria-related effects. METHODS: The effects on renal function of an acute infusion of sodium artesunate (12 mg/kg body weight) were studied in the rat with clearance techniques. We also evaluate the effect of sodium artesunate on chloride lumen-bath flux (Cl Jlb) in the isolated thick ascending limb of the loop of Henle (TALH) microperfused in vitro.

Author(s): 
Campos, S. B.
Rouch, L. H.
Seguro, A. C.
Publication Title: 
Metabolic Syndrome and Related Disorders

Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. In chronic kidney disease, FGF-23 levels rise with declining kidney function. Increasing FGF-23 levels are associated with increasing risk of mortality in dialysis patients. Two assays for FGF-23 have been reported. One assay detects only full-length/intact FGF-23. In contrast, the carboxy-terminal assay recognizes both intact and carboxy-terminal FGF-23.

Author(s): 
Devaraj, Sridevi
Duncan-Staley, Catherine
Jialal, Ishwarlal
Publication Title: 
Mayo Clinic Proceedings

OBJECTIVE: To identify single nucleotide polymorphisms (SNPs) associated with risk of developing chronic kidney disease (CKD), a prevalent comorbidity, after liver transplant (LT). PATIENTS AND METHODS: This study consists of a cohort of adult (> or =18 years) primary-LT recipients who had normal renal function before LT and who survived 1 year or more after LT at a high-volume US LT program between January 1, 1990, and December 31, 2000.

Author(s): 
Bambha, Kiran
Kim, W. Ray
Rosen, Charles B.
Pedersen, Rachel A.
Rys, Cynthia
Kolbert, Christopher P.
Cunningham, Julie M.
Therneau, Terry M.
Publication Title: 
Clinical journal of the American Society of Nephrology: CJASN

BACKGROUND AND OBJECTIVES: The burden of HIV-associated chronic kidney disease (CKD) is growing in the United States, partially because of increased HIV-infection rates among African Americans. We determined the prevalence, incidence, and risk of rapid estimated GFR (eGFR) decline, ESRD, and death among HIV-infected (HIV+) African-American and non-African-American individuals cared for at the Comprehensive Care Center in Nashville, Tennessee, from January 1, 1998, through December 31, 2005.

Author(s): 
Alves, Tahira P.
Hulgan, Todd
Wu, Pingsheng
Sterling, Timothy R.
Stinnette, Samuel E.
Rebeiro, Peter F.
Vincz, Andrew J.
Bruce, Marino
Ikizler, T. Alp

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