Glucosides

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Low-back pain is a common condition and a substantial economic burden in industrialized societies. A large proportion of patients with chronic low-back pain use complementary and alternative medicine (CAM), visit CAM practitioners, or both. Several herbal medicines have been purported for use in low-back pain. OBJECTIVES: To determine the effectiveness of herbal medicine for non-specific low-back pain.

Author(s): 
Gagnier, J. J.
van Tulder, M.
Berman, B.
Bombardier, C.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Low-back pain (LBP) is a common condition and imposes a substantial economic burden upon people living in industrialized societies. A large proportion of people with chronic LBP use complementary and alternative medicine (CAM), visit CAM practitioners, or both. Several herbal medicines have been purported for use in treating people with LBP. This is an update of a Cochrane Review first published in 2006. OBJECTIVES: To determine the effectiveness of herbal medicine for non-specific LBP.

Author(s): 
Oltean, Hanna
Robbins, Chris
van Tulder, Maurits W.
Berman, Brian M.
Bombardier, Claire
Gagnier, Joel J.
Publication Title: 
Biological & Pharmaceutical Bulletin

Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.

Author(s): 
Hamada, S.
Kataoka, T.
Woo, J. T.
Yamada, A.
Yoshida, T.
Nishimura, T.
Otake, N.
Nagai, K.
Publication Title: 
Planta Medica

The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid ( 1) and three galloyl glucoses ( 2 - 4). In addition, four flavonol glycoside gallates ( 5 - 8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2 - 4.

Author(s): 
Ahn, Mi-Jeong
Kim, Chul Young
Lee, Ji Suk
Kim, Tae Gyun
Kim, Seung Hee
Lee, Chong-Kyo
Lee, Bo-Bin
Shin, Cha-Gyun
Huh, Hoon
Kim, Jinwoong
Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: Chebulagic acid (CHE) from the immature seeds of Terminalia chebula was identified from a natural product library as a potent suppressor of T cell activity. This study examined the effectiveness of CHE against the onset and progression of collagen-induced arthritis (CIA) in mice. METHODS: Arthritis was induced in DBA/1J mice by subcutaneous immunization with bovine type II collagen on days 0 and 21. CHE was administered intraperitoneally for 3 weeks, either as prophylaxis (10 or 20 mg/kg) before disease onset or as therapy (20 mg/kg) after disease onset.

Author(s): 
Lee, Sang-Ik
Hyun, Pung-Mi
Kim, Seung-Hyung
Kim, Kyoung-Shin
Lee, Sang-Keun
Kim, Byoung-Soo
Maeng, Pil Jae
Lim, Jong-Soon
Publication Title: 
Journal of Separation Science

As a chromatographic column, the high-speed counter-current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two-phase solvent system was composed of n-hexane-ethyl acetate-methanol-water (1:20:1:20 v/v). As a result, 33.2 mg chebulagic and 15.8 mg chebulinic acids were obtained in one step from 300 mg of crude extract. Their purities were determined by HPLC to be 95.3 and 96.1%, respectively.

Author(s): 
Han, Quanbin
Song, Jingzheng
Qiao, Chunfeng
Wong, Lina
Xu, Hongxi
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Chebulagic acid, isolated form Terminalia chebula Retz, proved to be a reversible and non-competitive inhibitor of maltase with a K(i) value of 6.6 muM. The inhibitory influence of chebulagic acid on the maltase-glucoamylase complex was more potent than on the sucrase-isomaltase complex. The magnitude of alpha-glucosidase inhibition by chebulagic acid was greatly affected by its origin. These results show a use for chebulagic acid in managing type-2 diabetes.

Author(s): 
Gao, Hong
Huang, Yi-Na
Gao, Bo
Kawabata, Jun
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia chebula has an esteemed origin in Indian mythology; its fruits are used to treat many diseases such as digestive, diabetes, colic pain, chronic cough, sore throat, asthma, etc. AIM OF THE STUDY: The water or ethanolic extracts of the fruits were reported to have anti-oxidant, anti-inflammatory, anti-cancer and radio-protector properties. The present study is to isolate and identify the compounds that inhibit COX and 5-LOX, the key enzymes involved in inflammation and carcinogenesis.

Author(s): 
Reddy, D. Bharat
Reddy, T. C. M.
Jyotsna, G.
Sharan, Satish
Priya, Nalini
Lakshmipathi, V.
Reddanna, Pallu
Publication Title: 
Planta Medica

Phytochemical investigations of Terminalia arjuna bark and Terminalia chebula fruits resulted in the isolation of twelve triterpenoids including two new oleanane type triterpene glucosyl esters, ajunglucosides IV (1) and V (2), from the N-BuOH layer of the MeOH extract of T. arjuna bark as well as nine oleanane-type triterpenoids from the MeOH extract of the fruits of T. chebula.

Author(s): 
Wang, Wei
Ali, Zulfiqar
Li, Xing-Cong
Shen, Yunheng
Khan, Ikhlas A.
Publication Title: 
Natural Product Communications

Abhayarishta is an Ayurvedic formulation prepared traditionally by the fermentation of the decoction of Terminalia chebula (pericarp), Vitis vinifera (fruits), Embelia ribes (fruits) and Madhuca indica (flowers). In the present communication, chemical changes occurring during fermentation in Abhayarishta have been studied for the purpose of its standardization. An HPLC-DAD method for quantitative estimation of selected marker constituents in the formulation has been developed and validated.

Author(s): 
Lal, Uma Ranjan
Tripathi, Shailendra Mani
Jachak, Sanjay M.
Bhutani, Kamlesh Kumar
Singh, Inder Pal

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