Glutathione Peroxidase

Publication Title: 
Molecular and Cellular Biochemistry

Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) on noise-stress induced alterations in the antioxidant status and on the cell-mediated immune response in Wistar strain male albino rats. Noise-stress employed in this study was 100 dB for 4 h/d/15 days and Triphala was used at a dose of 1 g/kg/b.w/48 days.

Author(s): 
Srikumar, Ramasundaram
Parthasarathy, Narayanaperumal Jeya
Manikandan, Sundaramagalingam
Narayanan, Govindarajulu Sathya
Sheeladevi, Rathinasamy
Publication Title: 
Cell Biochemistry and Function

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers.

Author(s): 
Mahesh, Ramalingam
Bhuvana, Shanmugham
Begum, Vava Mohaideen Hazeena
Publication Title: 
The Journal of Nutrition

Restriction of energy intake (ER), without malnutrition of essential nutrients, has repeatedly been demonstrated to increase longevity in rodents. In the antioxidant theory of aging the lack of balance between the generation of free radicals and free radical scavenging was thought to be a main causal agent, in the aging process. From this point of view the antiaging effect induced by ER might be due to the lower rate of free-radical production and related damage induced by a lower metabolic rate. The antiaging effects of ER might also occur in humans.

Author(s): 
Velthuis-te Wierik, E. J.
van Leeuwen, R. E.
Hendriks, H. F.
Verhagen, H.
Loft, S.
Poulsen, H. E.
Van den Berg, H.
Publication Title: 
The Journal of Nutrition, Health & Aging

Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction (CR) increases longevity in animals. A total of 46 moderately overweight volunteers (BMI: 25-30 kg/m2), ages 20-42 yr were randomized to either high glycemic (HG) or low glycemic (LG) dietary load CR regimen at either 10% (n=12) or 30% (n=34) of basal caloric intake. All food was provided to participants for 6 mo.

Author(s): 
Meydani, M.
Das, S.
Band, M.
Epstein, S.
Roberts, S.
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Lifelong dietary methionine restriction (MR) is associated with increased longevity and decreased incidence of age-related disorders and diseases in rats and mice. A reduction in the levels of oxidative stress may be a contributing mechanistic factor for the beneficial effects of MR. To examine this, we determined the effects of an 80% dietary restriction of Met on different biomarkers of oxidative stress and antioxidant pathways in blood, liver, kidney and brain in the rat. Male F-344 rats were fed control (0.86% methionine) or MR (0.17% methionine) diets for up to six months.

Author(s): 
Maddineni, Sreenivasa
Nichenametla, Sailendra
Sinha, Raghu
Wilson, Ronald P.
Richie, John P.
Publication Title: 
The Journal of Nutritional Biochemistry

The present studies characterized the influence of dietary selenium (Na2SeO3) on the duration of pentobarbital (PB) induced hypnosis (sleep) in the rat. Rats were fed semipurified diets varying from 0.01 to 2.0 mg Se/kg for up to 4 weeks. Consumption of diets containing 1.0 and 2.0 mg Se/kg significantly prolonged PB induced hypnosis. Hepatic selenium, but not hepatic glutathione peroxidase activity, correlated with the length of PB induced hypnosis. The prolongation of hypnosis caused by diets containing 1.0 mg Se/kg was substantially reduced or eliminated by repeated exposure to PB.

Author(s): 
Debski, Bogdan
Milner, John A.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: Several studies suggest that yoga can decrease oxidative stress. However reports are scanty regarding whether yoga training can improve the glutathione level of individual. This study is designed to appraise the role of yoga in maintaining glutathione (reduced and oxidized) levels and antioxidant status. STUDY DESIGN: This study was conducted on healthy male volunteers from the Indian Navy, who were divided into two groups--a yoga (n = 30) group and a control (n = 21) group. The yoga group was trained in yoga for 6 months.

Author(s): 
Sinha, Sanchari
Singh, Som Nath
Monga, Y. P.
Ray, Uday Sankar
Publication Title: 
Journal of Ethnopharmacology

Ayurveda, practised in India, identified a large number of plant components to be used in the diet for the prevention or the delayed development of degenerative disorders. They include some of the commonly used spices, namely pepper and ginger. The Materia Medica includes both naturally occurring and artificially produced salts, as a partial substitute for common salt. Health promoting herbs and spices which are classified pharmacologically as rejuvenating, nourishing, invigorating, cleansing, wound-healing, etc., are used as food additives.

Author(s): 
Shanmugasundaram, K. R.
Ramanujam, S.
Shanmugasundaram, E. R.
Publication Title: 
Phytotherapy research: PTR

The effect of a standardized extract of Bacopa monniera Linn. was assessed on rat brain frontal cortical, striatal and hippocampal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities, following administration for 7, 14 or 21 days. The effects induced by this extract (bacoside A content 82% +/- 0.5%), administered in doses of 5 and 10 mg/kg, orally, were compared with the effects induced by (-) deprenyl (2 mg/kg, p. o.) administered for the same time periods.

Author(s): 
Bhattacharya, S. K.
Bhattacharya, A.
Kumar, A.
Ghosal, S.
Publication Title: 
Journal of Ethnopharmacology

Reactive oxygen intermediates (ROI) are together with prostanoids, leukotrienes and proteases, believed to be the mediators of inflammation and responsible for the pathogenesis of tissue destruction in RA. Antioxidant (AO) activity is one of the mechanisms by which many conventional drugs used in day to day treatment of RA alleviate the painful symptoms associated with this disease.

Author(s): 
Thabrew, M. I.
Senaratna, L.
Samarawickrema, N.
Munasinghe, C.

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