Glutathione Reductase

Publication Title: 
Cell Biochemistry and Function

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers.

Author(s): 
Mahesh, Ramalingam
Bhuvana, Shanmugham
Begum, Vava Mohaideen Hazeena
Publication Title: 
Annals of Nutrition & Metabolism

BACKGROUND: A vegetarian diet is considered to promote health and longevity and reduce the risk of cardiovascular diseases and cancer. However, a vegetarian diet may be deficient in some nutrients. Exclusion of animal products in vegetarian diets may affect the status of certain B-vitamins, and further cause the rise of plasma homocysteine concentration. OBJECTIVE: The nutritional status of various B-vitamins (B(1), B(2), B(6), B(12), folic acid) and the concentration of homocysteine in blood plasma of omnivores (n = 40), vegetarians (n = 36) and vegans (n = 42) in Austria was evaluated.

Author(s): 
Majchrzak, D.
Singer, I.
M‰nner, M.
Rust, P.
Genser, D.
Wagner, K.-H.
Elmadfa, I.
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Lifelong dietary methionine restriction (MR) is associated with increased longevity and decreased incidence of age-related disorders and diseases in rats and mice. A reduction in the levels of oxidative stress may be a contributing mechanistic factor for the beneficial effects of MR. To examine this, we determined the effects of an 80% dietary restriction of Met on different biomarkers of oxidative stress and antioxidant pathways in blood, liver, kidney and brain in the rat. Male F-344 rats were fed control (0.86% methionine) or MR (0.17% methionine) diets for up to six months.

Author(s): 
Maddineni, Sreenivasa
Nichenametla, Sailendra
Sinha, Raghu
Wilson, Ronald P.
Richie, John P.
Publication Title: 
Malaria Journal

BACKGROUND: Evaluating copy numbers of given genes in Plasmodium falciparum parasites is of major importance for laboratory-based studies or epidemiological surveys. For instance, pfmdr1 gene amplification has been associated with resistance to quinine derivatives and several genes involved in anti-oxidant defence may play an important role in resistance to antimalarial drugs, although their potential involvement has been overlooked.

Author(s): 
Ferreira, Isabel D.
Rosário, Virgílio E. do
Cravo, Pedro V. L.
Publication Title: 
PloS One

In Plasmodium falciparum-infected red blood cells (RBCs), the flavoenzyme glutathione reductase (GR) regenerates reduced glutathione, which is essential for antioxidant defense. GR utilizes NADPH produced in the pentose phosphate shunt by glucose-6-phosphate dehydrogenase (G6PD). Thus, conditions affecting host G6PD or GR induce increased sensitivity to oxidants. Hereditary G6PD deficiency is frequent in malaria endemic areas and provides protection against severe malaria.

Author(s): 
Gallo, Valentina
Schwarzer, Evelin
Rahlfs, Stefan
Schirmer, R. Heiner
van Zwieten, Rob
Roos, Dirk
Arese, Paolo
Becker, Katja
Publication Title: 
Drug Metabolism and Drug Interactions

Age related changes in the mitochondria of different regions of the CNS of two age groups of guinea-pigs (10 months and 32 months) were studied. The activities of glutathione peroxidase (GPx) and glutathione reductase (GRd) decreased significantly (p <0.05) with age in the mitochondrial fractions of cerebral cortex, hypothalamus, cerebellum and spinal cord. A significant (p <0.05) age related decrease in mitochondrial numerical density was observed in all regions studied. Electron microscopic observations revealed various degenerative changes in the mitochondria with age.

Author(s): 
Vohra, B. P.
Sharma, S. P.
Kansal, V. K.
Publication Title: 
Neurochemical Research

Sida cordifolia is a plant belonging to the Malvaceae family used in many ayurvedic preparations. This study aimed at assessing the effects of ethanolic extract of Sida cordifolia root on quinolinic acid (QUIN) induced neurotoxicity and to compare its effect with the standard drug deprenyl in rat brain.

Author(s): 
Swathy, S. S.
Panicker, Seema
Nithya, R. S.
Anuja, M. M.
Rejitha, S.
Indira, M.
Publication Title: 
Cellular and Molecular Neurobiology

Methyl mercury (MeHg) is a ubiquitous environmental pollutant leading to neurological and developmental deficits in animals and human beings. Bacopa monniera (BM) is a perennial herb and is used as a nerve tonic in Ayurveda, a traditional medicine system in India. The objective of the present study was to investigate whether Bacopa monniera extract (BME) could potentially inhibit MeHg-induced toxicity in the cerebellum of rat brain. Male Wistar rats were administered with MeHg orally at a dose of 5 mg/kg b.w. for 21 days.

Author(s): 
Sumathi, Thangarajan
Shobana, Chandrasekar
Christinal, Johnson
Anusha, Chandran
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

According to MEDLINE/Pubmed search to December 2009, the modulation effects of meditation on oxidative stress have been increasingly investigated for acute, short and long-term effects. Both invasive and noninvasive measurements have been utilized. Long-term transcendental and Zen meditators have been showed to diminish oxidative stress seen by a reduction of lipid peroxidation and biophoton emission.

Author(s): 
Mahagita, Chitrawina
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in the bactericidal function of phagocytes. Because Gsr has been implicated in the oxidative burst in human neutrophils and is abundantly expressed in the lymphoid system, we hypothesized that Gsr-deficient mice would exhibit marked defects during the immune response against bacterial challenge.

Author(s): 
Yan, Jing
Meng, Xiaomei
Wancket, Lyn M.
Lintner, Katherine
Nelin, Leif D.
Chen, Bernadette
Francis, Kevin P.
Smith, Charles V.
Rogers, Lynette K.
Liu, Yusen

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