Glycyrrhiza

Publication Title: 
International Journal of Toxicology

Glycyrrhetinic Acid and its salts and esters and Glycyrrhizic Acid and its salts and esters are cosmetic ingredients that function as flavoring agents or skin-conditioning agents - miscellaneous or both. These chemicals may be isolated from licorice plants. Glycyrrhetinc Acid is described as at least 98% pure, with 0.6% 24-OH-Glycyrrhetinic Acid, not more than 20 mu g/g of heavy metals and not more than 2 mu g/g of arsenic. Ammonium Glycyrrhizate has been found to be at least 98% pure and Dipotassium Glycyrrhizate has been found to be at least 95% pure.

Author(s): 
Cosmetic Ingredient Review Expert Panel
Publication Title: 
Oxidative Medicine and Cellular Longevity

The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats.

Author(s): 
Visavadiya, Nishant P.
Narasimhacharya, A. V. R. L.
Publication Title: 
Indian Journal of Experimental Biology

A panchagavya Ayurvedic formulation containing E. officinalis, G. glabra, and cow's ghee was evaluated for its effect on pentobarbital-induced sleeping time, pentylenetetrazol-induced seizures, maximal electroshock-induced seizures, spontaneous motor activity, rota-rod performance (motor coordination) and antagonism to amphetamine in mice. The formulation (300, 500 mg/kg, po) produced a significant prolongation of pentobarbital-induced sleeping time and reduced spontaneous locomotor activity.

Author(s): 
Achliya, Girish S.
Wadodkar, Sudhir G.
Avinash, K. Dorle
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Pepticare, a herbomineral formulation of the Ayurveda medicine consisting of the herbal drugs: Glycyrrhiza glabra, Emblica officinalis and Tinospora cordifolia, was tested for its anti-ulcer and anti-oxidant activity in rats. Effects of various doses (125, 250, 500 and 1000mg/kg, p.o.) of Pepticare were studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats.

Author(s): 
Bafna, P. A.
Balaraman, R.
Publication Title: 
Oxidative Medicine and Cellular Longevity

The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats.

Author(s): 
Visavadiya, Nishant P.
Narasimhacharya, A. V. R. L.
Publication Title: 
Molecular and Cellular Endocrinology

After the Women's Health Initiative found that the risks of hormone therapy outweighed the benefits, a need for alternative drugs to treat menopausal symptoms has emerged. We explored the possibility that botanical agents used in Traditional Chinese Medicine for menopausal symptoms contain ERbeta-selective estrogens. We previously reported that an extract containing 22 herbs, MF101 has ERbeta-selective properties. In this study we isolated liquiritigenin, the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, which is one of the plants found in MF101.

Author(s): 
Mersereau, Jennifer E.
Levy, Nitzan
Staub, Richard E.
Baggett, Scott
Zogovic, Tatjana
Zogric, Tetjana
Chow, Sylvia
Ricke, William A.
Tagliaferri, Mary
Cohen, Isaac
Bjeldanes, Leonard F.
Leitman, Dale C.
Publication Title: 
Journal of Agricultural and Food Chemistry

Glycyrrhiza uralensis (Gan-Cao), commonly called "licorice", is one of the most commonly used herbs in traditional Chinese medicine (TCM). In the United States, licorice products are most often consumed as flavoring and sweetening agents in food products. The licorice triterpenoid glycyrrhizin has several biological activities, including anti-inflammatory activity. Other potential anti-inflammatory constituents in G. uralensis have not been fully investigated. Airway eosinophilic inflammation is a major feature of allergic asthma.

Author(s): 
Jayaprakasam, Bolleddula
Doddaga, Srinivasulu
Wang, Rong
Holmes, Daniel
Goldfarb, Joseph
Li, Xiu-Min
Publication Title: 
Fitoterapia

Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening. While glabridin is one of the most studied licorice flavonoids, a comprehensive literature survey linked to its numerous bioactivities is unavailable. The present review provides a comprehensive description of glabridin as a key chemical and biological marker of G.

Author(s): 
Simmler, Charlotte
Pauli, Guido F.
Chen, Shao-Nong
Publication Title: 
PloS One

The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as hops (Humulus lupulus) and licorice (Glycyrrhiza spec.) to manage menopausal symptoms. Previous studies have shown estrogenic properties for hops, likely due to the presence of 8-prenylnarigenin, and chemopreventive effects mainly attributed to xanthohumol. Similarly, a combination of estrogenic and chemopreventive properties has been reported for various Glycyrrhiza species.

Author(s): 
Hajirahimkhan, Atieh
Simmler, Charlotte
Yuan, Yang
Anderson, Jeffrey R.
Chen, Shao-Nong
Nikolic, Dejan
Dietz, Birgit M.
Pauli, Guido F.
van Breemen, Richard B.
Bolton, Judy L.
Publication Title: 
Phytochemistry

Asthma is a serious health problem worldwide, particularly in industrialized countries. Despite a better understanding of the pathophysiology of asthma, there are still considerable gaps in knowledge as well as a need for classes of drugs. ASHMI™ (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora flavescens Aiton (Ku Shen) and Glycyrrhiza uralensis Fisch. ex DC (Gan Cao).

Author(s): 
Yang, Nan
Liang, Banghao
Srivastava, Kamal
Zeng, Jia
Zhan, Jixun
Brown, Laverne
Sampson, Hugh
Goldfarb, Joseph
Emala, Charles
Li, Xiu-Min

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