Graft vs Host Disease

Publication Title: 
Clinical and Experimental Immunology

Immunodeficient mice bearing targeted mutations in the IL2rg gene and engrafted with human immune systems are effective tools for the study of human haematopoiesis, immunity, infectious disease and transplantation biology. The most robust human immune model is generated by implantation of human fetal thymic and liver tissues in irradiated recipients followed by intravenous injection of autologous fetal liver haematopoietic stem cells [often referred to as the BLT (bone marrow, liver, thymus) model].

Author(s): 
Covassin, L.
Jangalwe, S.
Jouvet, N.
Laning, J.
Burzenski, L.
Shultz, L. D.
Brehm, M. A.
Publication Title: 
Bone Marrow Transplantation

The Sixth International Symposium on Graft-versus-Host and Graft-versus Leukemia Reactions was held in Schloss Ellmau (near Garmisch-Partenkirchen, Germany) between January 21 and 24, 2004. A total of 110 invited participants (scientists and clinicians working in the area of allogeneic stem cell transplantation) discussed current topics.

Author(s): 
Munker, R.
Schmid, C.
Madrigal, J. A.
Kolb, H. J.
Publication Title: 
Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association

BACKGROUND: We examined the alterations in gene expression associated with the development of crescentic glomerulonephritis in murine chronic graft-versus-host disease, a model for human systemic lupus erythematosus. METHODS: The disease was induced in (C57BL/6 x DBA/2) F(1) hybrids by injection of DBA/2 lymphocytes leading to deposition of auto-antibodies in the glomeruli, and a lupus type of nephritis morphologically.

Author(s): 
Ka, Shuk-Man
Rifai, Abdalla
Chen, Jan-Hen
Cheng, Chao-Wen
Shui, Hao-Ai
Lee, Herng-Sheng
Lin, Yuh-Feng
Hsu, Lai-Fa
Chen, Ann
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Allogeneic hematopoietic cell transplantation (HCT) is widely used to treat patients with life-threatening malignant and nonmalignant hematological diseases. However, allogeneic HCT often is accompanied by severe and lethal complications from graft-versus-host disease (GVHD), in which activated donor T cells recognize histocompatibility antigenic mismatches and cause significant toxicity in the recipient. In the current study, we tested the hypothesis that activation of cannabinoid receptors on donor-derived T cells may prevent GVHD.

Author(s): 
Pandey, Rupal
Hegde, Venkatesh L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
Blood

Graft-versus-host disease (GVHD) is a critical complication after allogeneic bone marrow transplantation. During GVHD, donor T cells are activated by host antigen-presenting cells and differentiate into T-effector cells (Teffs) that migrate to GVHD target organs. However, local environmental factors influencing Teff differentiation and migration are largely unknown. Vitamin A metabolism within the intestine produces retinoic acid, which contributes to intestinal homeostasis and tolerance induction.

Author(s): 
Aoyama, Kazutoshi
Saha, Asim
Tolar, Jakub
Riddle, Megan J.
Veenstra, Rachelle G.
Taylor, Patricia A.
Blomhoff, Rune
Panoskaltsis-Mortari, Angela
Klebanoff, Christopher A.
Socié, Gérard
Munn, David H.
Murphy, William J.
Serody, Jonathan S.
Fulton, Leshara M.
Teshima, Takanori
Chandraratna, Roshantha A.
Dmitrovsky, Ethan
Guo, Yanxia
Noelle, Randolph J.
Blazar, Bruce R.
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