Granulocyte-Macrophage Progenitor Cells

Publication Title: 
Radiation Research

FancD2 plays a central role in the human Fanconi anemia DNA damage response (DDR) pathway. Fancd2(-/-) mice exhibit many features of human Fanconi anemia including cellular DNA repair defects. Whether the DNA repair defect in Fancd2(-/-) mice results in radiologic changes in all cell lineages is unknown. We measured stress of hematopoiesis in long-term marrow cultures and radiosensitivity in clonogenic survival curves, as well as comet tail intensity, total antioxidant stores and radiation-induced gene expression in hematopoietic progenitor compared to bone marrow stromal cell lines.

Author(s): 
Berhane, Hebist
Epperly, Michael W.
Goff, Julie
Kalash, Ronny
Cao, Shaonan
Franicola, Darcy
Zhang, Xichen
Shields, Donna
Houghton, Frank
Wang, Hong
Wipf, Peter
Parmar, Kalindi
Greenberger, Joel S.
Publication Title: 
Cancer immunology, immunotherapy: CII

Bone marrow myelotoxicity is a major limitation of chemotherapy. While granulocyte colony stimulating factor (G-CSF) treatment is effective, alternative approaches to support hematopoietic recovery are sought. We previously found that a beta-glucan extract from maitake mushroom Grifola frondosa (MBG) enhanced colony forming unit-granulocyte monocyte (CFU-GM) activity of mouse bone marrow and human hematopoietic progenitor cells (HPC), stimulated G-CSF production and spared HPC from doxorubicin toxicity in vitro.

Author(s): 
Lin, Hong
de Stanchina, Elisa
Zhou, Xi Kathy
Hong, Feng
Seidman, Andrew
Fornier, Monica
Xiao, Wei-Lie
Kennelly, Edward J.
Wesa, Kathleen
Cassileth, Barrie R.
Cunningham-Rundles, Susanna
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