Grape Seed Extract

Publication Title: 
Gender Medicine

BACKGROUND: The onset of menopause marks a pivotal time in which the incidence of hypertension and of cardiovascular disease (CVD) begins to increase dramatically in women. Before menopause, the incidences of these diseases are significantly lower in women than in age-matched men. After menopause, the rates of these diseases in women eventually approximate those in men. The loss of endogenous estrogen at menopause has been traditionally believed to be the primary factor involved in these changes.

Author(s): 
Carlson, Scott
Peng, Ning
Prasain, Jeevan K.
Wyss, J. Michael
Publication Title: 
Journal of Alzheimer's disease: JAD

The present study explored the bioavailability and brain deposition of a grape seed polyphenolic extract (GSPE) previously found to attenuate cognitive deterioration in a mouse model of Alzheimer's disease (AD). Plasma pharmacokinetic response of major GSPE phenolic components was measured following intragastric gavage of 50, 100, and 150 mg GSPE per kg body weight. Liquid chromatography-mass spectrometry (LC-MS) analysis identified gallic acid (GA), catechin (C), and epicatechin (EC) in plasma of rats gavaged acutely with GSPE.

Author(s): 
Ferruzzi, Mario G.
Lobo, Jessica K.
Janle, Elsa M.
Cooper, Bruce
Simon, James E.
Wu, Qing-Li
Welch, Cara
Ho, Lap
Weaver, Connie
Pasinetti, Giulio M.
Publication Title: 
Molecular Carcinogenesis

Chemoprevention by dietary agents/supplements has emerged as a novel approach to control various malignancies, including colorectal cancer (CRC). This study assessed dietary grape seed extract (GSE) effectiveness in preventing azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated mechanisms in Fischer 344 rats. Six-week-old rats were injected with AOM, and fed control diet or the one supplemented with 0.25% or 0.5% (w/w) GSE in pre- and post-AOM or only post-AOM experimental protocols.

Author(s): 
Velmurugan, Balaiya
Singh, Rana P.
Agarwal, Rajesh
Agarwal, Chapla
Publication Title: 
Molecular Carcinogenesis

Abnormalities in cell cycle progression provide unlimited replicative potential to cancer cells, and therefore targeting of key cell cycle regulators could be a sound cancer chemopreventive strategy. Earlier, we found that grape seed extract (GSE) increases Cip/p21 protein level and inhibits growth and induces apoptosis in human colon carcinoma HT29 cells both in vitro and in vivo. However, the mechanism of GSE-induced p21 upregulation and its role in biological efficacy of GSE are not known, which were investigated here.

Author(s): 
Kaur, Manjinder
Tyagi, Alpna
Singh, Rana P.
Sclafani, Robert A.
Agarwal, Rajesh
Agarwal, Chapla
Publication Title: 
The Journal of Nutrition

We previously reported that (-)-epigallocatechin-3-gallate (EGCG) and grape seed extract (GSE) at high concentration nearly blocked intestinal iron transport across the enterocyte. In this study, we aimed to determine whether small amounts of EGCG, GSE, and green tea extract (GT) are capable of inhibiting iron absorption, to examine if ascorbic acid counteracts the inhibitory action of polyphenols on iron absorption, and to explore the mechanisms of polyphenol-mediated apical iron uptake and basolateral iron release.

Author(s): 
Kim, Eun-Young
Ham, Soo-Kyung
Bradke, Daniel
Ma, Qianyi
Han, Okhee
Publication Title: 
Neurobiology of Aging

Tauopathies are characterized by progressive neurodegeneration caused by intracellular accumulation of hyperphosphorylated tau protein aggregates in the brain. The present study was designed to test whether a grape seed polyphenolic extract (GSPE) previously shown to inhibit tau protein aggregation in vitro could benefit tau-mediated neuropathology and behavior deficits in JNPL3 transgenic mice expressing a human tau protein containing the P301L mutation. Nine-month-old JNPL3 mice were treated with GSPE delivered through their drinking water for 6 months.

Author(s): 
Santa-Maria, Ismael
Diaz-Ruiz, Carmen
Ksiezak-Reding, Hanna
Chen, Alice
Ho, Lap
Wang, Jun
Pasinetti, Giulio Maria
Publication Title: 
Journal of Food Science

Although heme iron is an important form of dietary iron, its intestinal absorption mechanism remains elusive. Our previous study revealed that (-)-epigallocatechin-3-gallate (EGCG) and grape seed extract (GSE) markedly inhibited intestinal heme iron absorption by reducing the basolateral iron export in Caco-2 cells. The aim of this study was to examine whether small amounts of EGCG, GSE, and green tea extract (GT) could inhibit heme iron absorption, and to test whether the inhibitory action of polyphenols could be offset by ascorbic acid.

Author(s): 
Ma, Qianyi
Kim, Eun-Young
Lindsay, Elizabeth Ann
Han, Okhee
Publication Title: 
The Journal of Nutrition

The (n-3) PUFAs 20:5 (n-3) (EPA) and 22:6 (n-3) (DHA) are thought to benefit human health. The presence of prooxidant compounds in foods, however, renders them susceptible to oxidation during both storage and digestion. The development of oxidation products during digestion and the potential effects on intestinal PUFA uptake are incompletely understood.

Author(s): 
Maestre, Rodrigo
Douglass, John D.
Kodukula, Sarala
Medina, Isabel
Storch, Judith
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Colorectal cancer (CRC) is the second leading cause of cancer-associated deaths, suggesting that additional strategies are needed to prevent/control this malignancy. As CRC growth and progression involve a large window (10-15 years), chemopreventive intervention could be a practical/translational strategy. Azoxymethane (AOM)-induced colon tumorigenesis in mice resembles human CRC in terms of progression of ACF to polyps, adenoma, and carcinomas and associated molecular mechanisms.

Author(s): 
Derry, Molly M.
Raina, Komal
Balaiya, Velmurugan
Jain, Anil K.
Shrotriya, Sangeeta
Huber, Kendra M.
Serkova, Natalie J.
Agarwal, Rajesh
Agarwal, Chapla
Publication Title: 
Nutrition and Cancer

The present study examines grape seed extract (GSE) efficacy against a series of non-small-cell lung cancer (NSCLC) cell lines that differ in their Kras and p53 status to establish GSE potential as a cytotoxic agent against a wide range of lung cancer cells. GSE suppressed growth and induced apoptotic death in NSCLC cells irrespective of their k-Ras status, with more sensitivity toward H460 and H322 (wt k-Ras) than A549 and H1299 cells (mutated k-Ras).

Author(s): 
Tyagi, Alpna
Raina, Komal
Gangar, Subhash
Kaur, Manjinder
Agarwal, Rajesh
Agarwal, Chapla

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