HDAC inhibitors

Publication Title: 
Neuropharmacology

Alzheimer' s disease (AD) is the most common form of dementia causing an increasing emotional and economical burden to our societies. Although much progress has been made regarding the molecular mechanisms that underlie AD pathogenesis effective therapies are not available yet. The emerging field of neuroepigenetics has provided evidence that de-regulation of epigenetic processes play a role in AD.

Author(s): 
Fischer, Andre
Publication Title: 
Epigenomics

Huntington's disease is a late-onset, autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric symptomatology. The earliest stage of Huntington's disease is marked by alterations in gene expression, which partially results from dysregulated epigenetic modifications.

Author(s): 
Wang, Fengli
Fischhaber, Paula L.
Guo, Caixia
Tang, Tie-Shan
Publication Title: 
The International Journal of Biochemistry & Cell Biology

The study of epigenetics is providing novel insights about the functional and developmental complexity of the nervous system. In neuropathology, therapies aimed at correcting epigenetic dysregulation have been extensively documented in a large variety of models for neurodegenerative, neurodevelopmental and psychiatric disorders.

Author(s): 
Valor, Luis M.
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