Head and Neck Neoplasms

Publication Title: 
International Journal of Oral and Maxillofacial Surgery

Head and neck cancer represents one of the main oncological problems. Its treatment, radiotherapy and chemotherapy leads to mucositis, and other side effects. The authors reviewed high-quality evidence published over the last 25 years on the treatment of cancer treatment-induced oral mucositis. A Medline search for double blind randomized controlled clinical trials between 1985 and 2010 was carried out. The keywords were oral mucositis, radiotherapy, chemotherapy, and head and neck.

Rodríguez-Caballero, A.
Torres-Lagares, D.
Robles-García, M.
Pachón-Ibáñez, J.
González-Padilla, D.
Gutierrez-Perez, J. L.
Publication Title: 
Acupuncture in Medicine: Journal of the British Medical Acupuncture Society

BACKGROUND: Irradiation-induced xerostomia seriously reduces quality of life for patients with head and neck cancer (HNC). Anecdotal evidence suggests that acupuncture may be beneficial. OBJECTIVE: To systematically review evidence on clinical effectiveness and safety of acupuncture in irradiation-induced xerostomia in patients with HNC. METHODS: A detailed search was performed to identify randomised controlled trials (RCTs) and systematic reviews of RCTs on acupuncture in irradiation-induced xerostomia, using AMED, BNIA, CINAHL, Cochrane, Embase, HPSI, PsycInfo and Medline.

O'Sullivan, E. M.
Higginson, I. J.
Publication Title: 
Integrative Cancer Therapies

BACKGROUND: Methods currently available to prevent and manage xerostomia which caused by radiotherapy in patients with head and neck caner have limited efficacy. Some studies suggest that acupuncture may be beneficial. OBJECTIVES: The authors evaluated the preventive and therapeutic effect of acupuncture for radiation-induced xerostomia among patients with head and neck cancer.

Zhuang, Liping
Yang, Zongguo
Zeng, Xiantao
Zhua, Xiaoyan
Chen, Zhen
Liu, Luming
Meng, Zhiqiang
Publication Title: 
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

OBJECTIVE: To analyze the efficacy of various treatment options for radiation-induced hyposalivation in patients with head and neck cancer. STUDY DESIGN: A literature review and meta-analysis was performed on all appropriate literature identified via MEDLINE/PubMed. RESULTS: Fourteen articles were identified that met inclusion criteria for review, and 8 articles qualified for inclusion in the meta-analysis.

Lovelace, Tiffany L.
Fox, Nyssa F.
Sood, Amit J.
Nguyen, Shaun A.
Day, Terry A.
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: To assess the efficacy of rapamycin treatment in chemoprevention and chemotherapy of tumorigenesis in a genetically defined mouse model of head and neck squamous cell carcinoma (HNSCC). Experimental design: Knockdown of Tgfbr1 and/or Pten using siRNA-mediated RNA interference was carried out in human HNSCC cell lines to analyze molecular changes in the mTOR pathway. Tgfbr1(flox/flox); Pten(flox/flox); K14-CreER(tam) mice were treated with oral gavage of tamoxifen for the conditional deletion of Tgfbr1 and Pten in oral mucosa, resulting in HNSCC.

Sun, Zhi-Jun
Zhang, Lu
Hall, Bradford
Bian, Yansong
Gutkind, J. Silvio
Kulkarni, Ashok B.
Publication Title: 
Revue De Laryngologie - Otologie - Rhinologie

OBJECTIVE: Authors reported the results of a study on the application of immunonutrion in peri-operative (pre and postoperative) in head and neck cancer for all patients malnourished or not. In preoperative we used an oral treatmentand in postoperative an enteral one. MATERIALS AND METHODS: Prospective study concerning 78 patients (47 malnourished versus 31 not) having had heavy head and neck curative cancerology surgery. The mean follow up was of 10 months (from 7 to 16 month).

Mayaleh, H. Abou
Vayer, C.
Amsellem, C.
Bouvet, A.
Duval, N.
Poiree, B.
Tran, M.
Lepeltier, V.
Hitier, M.
Rame, J. P.
Louis, Y.
De Raucourt, D.
Publication Title: 
The International Journal of Clinical and Experimental Hypnosis

The value of a brief, preoperative hypnosis experience was explored with a sample of 36 head and neck cancer surgery patients. 15 patients volunteered for the experimental hypnosis intervention. 21 patients who received usual care (no hypnosis) were followed through their hospital charts and were used as a comparison group. Hypnotic intervention and usual care groups were comparable in terms of relevant demographic variables. Postoperative hospitalizations for the hypnotic intervention group were significantly shorter than for the usual care group.

Rapkin, D. A.
Straubing, M.
Holroyd, J. C.
Publication Title: 
The Laryngoscope

HYPOTHESIS/OBJECTIVE: The use of complementary or alternative medicine (CAM) is growing among cancer patients. A Medline search failed to reveal any dedicated report of CAM use specifically in patients with head and neck cancer (HNC). STUDY DESIGN: Use of CAM was evaluated in a cohort of treated HNC patients. METHODS: Patients treated for HNC were asked if they had used CAM since their diagnosis. Demographic data and data pertaining to mode of CAM, duration of treatment and effects were obtained. RESULTS: One hundred forty-three patients (mean age 61 years) were included.

Talmi, Yoav P.
Yakirevitch, Arkadi
Migirov, Lela
Horowitz, Zeev
Bedrin, Lev
Simon, Zvi
Pfeffer, M. Raphael
Publication Title: 
Journal of Pain and Symptom Management

Xerostomia, the sensation of dry mouth, affects almost all patients who undergo radiotherapy for cancer in the head and neck area. Current therapies for xerostomia are inadequate, and the condition negatively impacts the quality of life. This prospective observational pilot study aimed to evaluate whether hypnosis could improve salivation and decrease xerostomia. Twelve patients with xerostomia after radiotherapy for head and neck cancer were assessed for severity of xerostomia symptoms and sialometry.

Schiff, Elad
Mogilner, Jorge G.
Sella, Eyal
Doweck, Ilana
Hershko, Oded
Ben-Arye, Eran
Yarom, Noam
Publication Title: 
Molecular Cancer

Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis and metastasis.

Wilken, Reason
Veena, Mysore S.
Wang, Marilene B.
Srivatsan, Eri S.


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