Health Status

Publication Title: 
Molecular Nutrition & Food Research

Vitamin E refers to a family of several compounds that possess a similar chemical structure comprising a chromanol ring with a 16-carbon side chain. The degree of saturation of the side chain, and positions and nature of methyl groups designate the compounds as tocopherols or tocotrienols. Vitamin E compounds have antioxidant properties due to a hydroxyl group on the chromanol ring. Recently, it has been suggested that vitamin E may also regulate signal transduction and gene expression.

Author(s): 
Banks, Ruth
Speakman, John R.
Selman, Colin
Publication Title: 
Community Dentistry and Oral Epidemiology

OBJECTIVE: Fluoride was first added to the Australian water supply in 1953, and by 2003, 69% of Australia's population was receiving the minimum recommended dose. Extending coverage of fluoridation to all remaining communities of at least 1000 people is a key strategy of Australia's National Oral Health Plan 2004-2013. We evaluate the cost-effectiveness of this strategy from an Australian health sector perspective. METHODS: Health gains from the prevention of caries in the Australian population are modelled over the average 15-year lifespan of a treatment plant.

Author(s): 
Cobiac, Linda J.
Vos, Theo
Publication Title: 
JAMA: the journal of the American Medical Association
Author(s): 
Friedrich, M. J.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%.

Author(s): 
Karasik, David
Demissie, Serkalem
Cupples, L. Adrienne
Kiel, Douglas P.
Publication Title: 
Archives of Gerontology and Geriatrics

The present study aims at describing the health status of a sample of relatively functional and healthy Greek centenarians and at exploring the potential gender differences in health in this sample. Its objectives are to add to the accumulation of knowledge about the health status of centenarians and therefore to contribute to the exploration of the mechanisms of healthy longevity. The study employs a non-representative community sample of Greek centenarians of both sexes (N=47).

Author(s): 
Darviri, Christina
Demakakos, Panayotes
Charizani, Fotini
Tigani, Xanthi
Tsiou, Chrysoula
Chalamandaris, Alexandros G.
Tsagkari, Christina
Chliaoutakis, Joannnes
Publication Title: 
Archives of Internal Medicine

BACKGROUND: Prospective data on nongenetic determinants of exceptional longevity are limited, and information on long-lived men and their functional status is particularly sparse. We examined modifiable factors associated with a life span of 90 or more years and late-life function in men. METHODS: In this prospective cohort study of 2357 healthy men (mean age, 72 years) within the Physicians' Health Study (1981-2006), biological and lifestyle factors and comorbid conditions were assessed by self-report with baseline and annual questionnaires.

Author(s): 
Yates, Laurel B.
DjoussÈ, Luc
Kurth, Tobias
Buring, Julie E.
Gaziano, J. Michael
Publication Title: 
American Journal of Public Health

OBJECTIVES: We investigated the characteristics of the oldest old in China and examined whether the factors associated with longevity varied with advanced age. METHODS: Drawing from the largest nationally representative longitudinal sample of oldest-old adults, we stratified descriptive statistics separately by gender and urban-rural residence and then used ordered logit models to examine the multivariate factors associated with increasing age-group membership.

Author(s): 
Dupre, Matthew E.
Liu, Guangya
Gu, Danan
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Prior animal model studies have demonstrated an association between telomere length and longevity. Our study examines telomere length in centenarians in good health versus poor health. Using DNA from blood lymphocytes, telomere length was measured by quantitative polymerase chain reaction in 38 sex- and age-matched centenarians (ages 97-108).

Author(s): 
Terry, Dellara F.
Nolan, Vikki G.
Andersen, Stacy L.
Perls, Thomas T.
Cawthon, Richard
Publication Title: 
Archives of Internal Medicine

BACKGROUND: Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear. METHODS: A total of 13,535 Nurses' Health Study participants who were free of major chronic diseases at baseline in 1986 and had survived to age 70 years or older as of the 1995-2001 period made up the study population.

Author(s): 
Sun, Qi
Townsend, Mary K.
Okereke, Olivia I.
Franco, Oscar H.
Hu, Frank B.
Grodstein, Francine
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts for the Long Life Family Study, endophenotypes that represent exceptional survival were identified and heritability estimates were calculated. Principal components (PCs) analysis was carried out using 28 physiologic measurements from five trait domains (cardiovascular, cognition, physical function, pulmonary, and metabolic).

Author(s): 
Matteini, Amy M.
Fallin, M. Daniele
Kammerer, Candace M.
Schupf, Nicole
Yashin, Anatoli I.
Christensen, Kaare
Arbeev, Konstantin G.
Barr, Graham
Mayeux, Richard
Newman, Anne B.
Walston, Jeremy D.

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