Healthy Volunteers

Publication Title: 
Retrovirology

BACKGROUND: A subset of CD3(neg)CD56(neg)CD16⁺ Natural Killer (NK) cells is highly expanded during chronic HIV-1 infection. The role of this subset in HIV-1 pathogenesis remains unclear. The lack of NK cell lineage-specific markers has complicated the study of minor NK cell subpopulations. RESULTS: Using CD7 as an additional NK cell marker, we found that CD3(neg)CD56(neg)CD16⁺ cells are a heterogeneous population comprised of CD7⁺ NK cells and CD7(neg) non-classical myeloid cells. CD7⁺CD56(neg)CD16⁺ NK cells are significantly expanded in HIV-1 infection.

Author(s): 
Milush, Jeffrey M.
López-Vergès, Sandra
York, Vanessa A.
Deeks, Steven G.
Martin, Jeffrey N.
Hecht, Frederick M.
Lanier, Lewis L.
Nixon, Douglas F.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Excessive or persistent proinflammatory cytokine production plays a central role in autoimmune diseases. Acute activation of the sympathetic nervous system attenuates the innate immune response. However, both the autonomic nervous system and innate immune system are regarded as systems that cannot be voluntarily influenced. Herein, we evaluated the effects of a training program on the autonomic nervous system and innate immune response. Healthy volunteers were randomized to either the intervention (n = 12) or control group (n = 12).

Author(s): 
Kox, Matthijs
van Eijk, Lucas T.
Zwaag, Jelle
van den Wildenberg, Joanne
Sweep, Fred C. G. J.
van der Hoeven, Johannes G.
Pickkers, Peter
Publication Title: 
Lipids in Health and Disease

BACKGROUND: Higenamine, also known as norcoclaurine, is an herbal constituent thought to act as a beta-2 adrenergic receptor agonist-possibly stimulating lipolysis. It was the purpose of this study to determine the impact of a higenamine-based dietary supplement on plasma free fatty acids and energy expenditure following acute oral ingestion.

Author(s): 
Lee, Sang-Rok
Schriefer, Johnhenry M.
Gunnels, Trint A.
Harvey, Innocence C.
Bloomer, Richard J.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: Quantification of chiropractic high-velocity, low-amplitude spinal manipulation (HVLA-SM) may require biomechanical equipment capable of sampling data at high rates. However, there are few studies reported in the literature regarding the minimal sampling rate required to record the HVLA-SM force-time profile data accurately and precisely. The purpose of this study was to investigate the effect of different sampling rates on the quantification of forces, durations, and rates of loading of simulated side posture lumbar spine HVLA-SM delivered by doctors of chiropractic.

Author(s): 
Gudavalli, Maruti Ram
DeVocht, James
Tayh, Ali
Xia, Ting
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: Moxibustion has long been thought to promote vital energy or immunity through clinical experience. This study aimed to investigate the clinical effects of indirect moxibustion on antioxidant and immunomodulation in a normal population. METHODS: Twenty-five healthy volunteers with no objective or subjective disorders were recruited. The participants were treated with indirect moxibustion on acupoints Guanyuan (CV 4) and Shenque (CV 8) three times per week for 4 weeks.

Author(s): 
Park, Hyejung
Kim, Hyeunggeug
Yoo, Sara
Lee, Namhun
Son, Changgue

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