Hematocrit

Publication Title: 
Acta Poloniae Pharmaceutica

The present investigation was an attempt to evaluate the anti-inflammatory effect of a polyherbal preparation (Sudarshanam Oil) on hematological parameters in Wistar rats. This polyherbal formula contains main ingredients of Tinaspora Cordifolia, Curcuma longa, Terminalia chebula, Emblica officinalis, Andrographis paniculata and Terminalia belerica. The active phytochemicals such as tannins, glycosides, flavonoids and triterpenoids are extracted from these herbal plants. And extract was prepared in corn oil.

Author(s): 
Patel, Chintan D.
Modi, Vandana D.
Chakraborty, Bhaswat S.
Mathuria, Neeta
Dadhaniya, Paresh
Borade, Prasad A.
Morankar, Pravin
Publication Title: 
Antimicrobial Agents and Chemotherapy

The purpose of the present study was to characterize the partitioning of artemisinin into both uninfected and Plasmodium falciparum-infected red blood cells (RBCs). The partitioning of [(14)C](+)-artemisinin into RBCs was studied at four different hematocrit levels and eight time periods. At the optimum time of 2 h, the partitioning process was investigated with eight different drug concentrations ranging from 0.88 to 3.52 microM at 37 and 4 degrees C. The effect of the presence of unlabeled artemisinin on the partitioning of the same concentration of [(14)C]artemisinin was studied.

Author(s): 
Vyas, Nehal
Avery, Bonnie A.
Avery, Mitchell A.
Wyandt, Christy M.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. In view of concern about the potential long-term toxicity, rats were treated orally with 80 mg/kg artemether once every 2 weeks for 5 months. After the final treatment, routine blood test results were normal except for reversible reductions of reticulocyte counts and reversible increases in hemoglobin levels.

Author(s): 
Xiao, Shuhua
Yang, Yuanqing
You, Qiqing
Utzinger, Jürg
Guo, Huifang
Peiying, Jiao
Mei, Jinying
Guo, Jian
Bergquist, Robert
Tanner, Marcel
Publication Title: 
Bulletin of the World Health Organization

OBJECTIVE: To evaluate the therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine, and the sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated Plasmodium falciparum malaria in young children in Cameroon.

Author(s): 
Basco, Leonardo K.
Same-Ekobo, Albert
Ngane, Vincent Foumane
Ndounga, Mathieu
Metoh, Theresia
Ringwald, Pascal
Soula, Georges
Publication Title: 
British Journal of Clinical Pharmacology

AIMS: To assess the haemodynamic, electrocardiographic and glycaemic effects of piperaquine-dihydroartemisinin (Artekin) fixed combination therapy in uncomplicated malaria. METHODS: Sixty-two Cambodians (32 children and 30 adults) with falciparum or vivax malaria were given Artekin given as four age-based oral doses over 32 h. Supine and erect blood pressure, the electrocardiographic QT interval and plasma glucose were measured before treatment and then at regular intervals during a 4-day admission period as part of efficacy and safety monitoring.

Author(s): 
Karunajeewa, Harin
Lim, Chiv
Hung, Te-Yu
Ilett, Kenneth F.
Denis, Mey Bouth
Socheat, Doung
Davis, Timothy M. E.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The treatment efficacy and effects of artesunate-mefloquine (AMQ) and mefloquine (MQ) on malaria-associated anemia (MAA) were evaluated in 342 children <or= 10 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive either drug/drug combination. All children recovered clinically. Fever clearance times were similar. Parasite clearance was significantly faster with AMQ (mean +/- SD = 1.4 +/- 0.6 days, 95% confidence interval [CI] = 1.3-1.5, P < 0.0001), but polymerase chain reaction-corrected cure rates were similar (97% versus 94%).

Author(s): 
Sowunmi, Akintunde
Gbotosho, Grace O.
Happi, Christian
Okuboyejo, Titilope
Folarin, Onikepe
Balogun, Sulayman
Michael, Obaro
Publication Title: 
American Journal of Therapeutics

To evaluate the effects of antimalarial drugs on Plasmodium falciparum malaria-associated anemia, we use the area under the curve (AUC) of anemia levels after treatment as an approach to combine their duration and magnitude. The method involves numeric estimation, by trapezoidal rule, of AUC from a plot of deficit in hematocrit levels from 30% (the lower threshold of normal) versus time in anemic children.

Author(s): 
Sowunmi, Akintunde
Gbotosho, Grace Olusola
Happi, Christian Tientcha
Folarin, Onikepe
Okuboyejo, Titilope
Michael, Obaro
Fatunmbi, Bayo
Publication Title: 
Antimicrobial Agents and Chemotherapy

Intermittent preventive treatment (IPT) is increasingly used to reduce malaria morbidity and mortality in children and pregnant women. The efficacy of IPT depends on the pharmacokinetic and pharmacodynamic properties of the antimalarial drugs used. Healthy adult male volunteers whose occupation put them at high risk of malaria on the Northwest border of Thailand were randomized to receive a 3-day-treatment dose of dihydroartemisinin-piperaquine monthly (DPm) or every 2 months (DPalt) or an identical placebo with or without fat (6.4 g/dose) over a 9-month period.

Author(s): 
Lwin, Khin Maung
Phyo, Aung Pyae
Tarning, Joel
Hanpithakpong, Warunee
Ashley, Elizabeth A.
Lee, Sue J.
Cheah, Phaikyeong
Singhasivanon, Pratap
White, Nicholas J.
Lindegardh, Niklas
Nosten, François
Publication Title: 
The Journal of Toxicological Sciences

The aim of the present investigation deals with the hematology and hepatorenal function of Caesalpinia bonducella Flem. and Bauhinia racemosa Lam. belonging to the Family: Caesalpiniaceae, and used in the traditional system of medicine. The tribal people of Kolli Hills, Tamil Nadu, India, use the leaves of Caesalpinia bonducella and the stem bark of Bauhinia racemosa in combination with some other herbs for the treatment of various tumors, liver disorders, inflammation and some other diseases. In ancient Ayurveda medicine these plants were mentioned to possess antitumor agents.

Author(s): 
Kumar, Ramanathan Sambath
Gupta, Malaya
Mazumdar, Upal Kanti
Rajeshwar, Yerra
Kumar, Thangavel Siva
Gomathi, Periaswamy
Roy, Rathnamala
Publication Title: 
The Journal of Toxicological Sciences

The aim of the present investigation deals with the hematology and hepatorenal function of Caesalpinia bonducella Flem. and Bauhinia racemosa Lam. belonging to the Family: Caesalpiniaceae, and used in the traditional system of medicine. The tribal people of Kolli Hills, Tamil Nadu, India, use the leaves of Caesalpinia bonducella and the stem bark of Bauhinia racemosa in combination with some other herbs for the treatment of various tumors, liver disorders, inflammation and some other diseases. In ancient Ayurveda medicine these plants were mentioned to possess antitumor agents.

Author(s): 
Kumar, Ramanathan Sambath
Gupta, Malaya
Mazumdar, Upal Kanti
Rajeshwar, Yerra
Kumar, Thangavel Siva
Gomathi, Periaswamy
Roy, Rathnamala

Pages

Subscribe to RSS - Hematocrit