Hematologic Neoplasms

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Malignant neoplasms of the lymphoid or myeloid cell lines including lymphoma, leukaemia and myeloma are referred to as haematological malignancies. Complementary and alternative treatment options such as meditation practice or yoga are becoming popular by treating all aspects of the disease including physical and psychological symptoms. However, there is still unclear evidence about meditation's effectiveness, and how its practice affects the lives of haematologically-diseased patients.

Author(s): 
Salhofer, Ines
Will, Andrea
Monsef, Ina
Skoetz, Nicole
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Although people with haematological malignancies have to endure long phases of therapy and immobility which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patients suffer. The inability to perform activities of daily living restricts them, diminishes their quality of life and can influence medical therapy.

Author(s): 
Bergenthal, Nils
Will, Andrea
Streckmann, Fiona
Wolkewitz, Klaus-Dieter
Monsef, Ina
Engert, Andreas
Elter, Thomas
Skoetz, Nicole
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Malignant neoplasms of the lymphoid or myeloid cell lines including lymphoma, leukaemia and myeloma are referred to as haematological malignancies. Complementary and alternative treatment options such as meditation practice or yoga are becoming popular by treating all aspects of the disease including physical and psychological symptoms. However, there is still unclear evidence about meditation's effectiveness, and how its practice affects the lives of haematologically-diseased patients.

Author(s): 
Salhofer, Ines
Will, Andrea
Monsef, Ina
Skoetz, Nicole
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Although people with haematological malignancies have to endure long phases of therapy and immobility which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patients suffer. The inability to perform activities of daily living restricts them, diminishes their quality of life and can influence medical therapy.

Author(s): 
Bergenthal, Nils
Will, Andrea
Streckmann, Fiona
Wolkewitz, Klaus-Dieter
Monsef, Ina
Engert, Andreas
Elter, Thomas
Skoetz, Nicole
Publication Title: 
Critical Reviews in Oncogenesis

Aging of the hematological system causes anemia, reduced immunity, and increased incidence of hematological malignancies. Hematopoietic stem cells (HSCs) play a crucial role in this process as their functions decline during aging. Sirtuins are a family of protein lysine modifying enzymes that have diverse roles in regulating metabolism, genome stability, cell proliferation, and survival, and have been implicated in mammalian aging and longevity.

Author(s): 
Roth, Mendel
Wang, Zhiqiang
Chen, Wen Yong
Publication Title: 
Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association

BACKGROUND: Chronic kidney disease (CKD) seems to be common in long-term survivors of haematopoietic cell transplantation (HCT). However, the range of its frequency is very wide, likely due to variability in the definitions of CKD and the periods of follow-up. METHODS: We conducted a cross-sectional and retrospective study in 158 adults who received myeloablative allogeneic HCT for lymphohaematologic malignancies at least 3 years ago and are alive today. The mean survival time was 6.15 +/- 4.88 years (range: 3-16 years).

Author(s): 
Ando, Minoru
Ohashi, Kazuteru
Akiyama, Hideki
Sakamaki, Hisashi
Morito, Taku
Tsuchiya, Ken
Nitta, Kosaku
Publication Title: 
International Journal of Nursing Practice

The findings indicate that there are many potentially positive outcomes, couched in terms of a spiritual journey, to be gained from the experience of serious illness for survivors who are well supported and obtain successful results from treatment. The work is from a qualitative programme exploring the notion of spirituality. The data are from the thematic analysis of verbatim transcriptions of audio-taped, in-depth, open-ended interviews with 12 survivors of haematological malignancies.

Author(s): 
McGrath, Pam
Publication Title: 
Blood

JAK-STAT signaling is involved in the regulation of cell survival, proliferation, and differentiation. JAK tyrosine kinases can be transiently activated by cytokines or growth factors in normal cells, whereas they become constitutively activated as a result of mutations that affect their function in tumors. Specifically, the JAK2V617F mutation is present in the majority of patients with myeloproliferative disorders (MPDs) and is implicated in the pathogenesis of these diseases.

Author(s): 
Zheng, Ying
Qin, Hongwei
Frank, Stuart J.
Deng, Luqin
Litchfield, David W.
Tefferi, Ayalew
Pardanani, Animesh
Lin, Fang-Tsyr
Li, Jingzhi
Sha, Bingdong
Benveniste, Etty N.
Publication Title: 
Anti-Cancer Agents in Medicinal Chemistry

Sphingosine-1-phosphate (S1P) is a bioactive lipid with diverse functions including the promotion of cell survival, proliferation and migration, as well as the regulation of angiogenesis, inflammation, immunity, vascular permeability and nuclear mechanisms that control gene transcription. S1P is derived from metabolism of ceramide, which itself has diverse and generally growth-inhibitory effects through its impact on downstream targets involved in regulation of apoptosis, senescence and cell cycle progression.

Author(s): 
Loh, Kenneth C.
Baldwin, Dianna
Saba, Julie D.
Publication Title: 
Pediatrics

BACKGROUND: Children undergoing stem cell transplantation (SCT) are thought to be at risk for increased distress, adjustment difficulties, and impaired health-related quality of life (HRQL). We report results of a multisite trial designed to improve psychological adjustment and HRQL in children undergoing SCT. METHODS: A total of 171 patients and parents from 4 sites were randomized to receive a child-targeted intervention; a child and parent intervention; or standard care.

Author(s): 
Phipps, Sean
Peasant, Courtney
Barrera, Maru
Alderfer, Melissa A.
Huang, Qinlei
Vannatta, Kathryn

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