Hematopoietic Stem Cell Transplantation

Publication Title: 
Stem Cells Translational Medicine

Self-renewal and multilineage differentiation of stem cells are keys to the lifelong homeostatic maintenance of tissues and organs. Hematopoietic aging, characterized by immunosenescence, proinflammation, and anemia, is attributed to age-associated changes in the number and function of hematopoietic stem cells (HSCs) and their microenvironmental niche. Genetic variants and factors regulating stem cell aging are correlatively or causatively associated with overall organismal aging and longevity.

Author(s): 
Van Zant, Gary
Liang, Ying
Publication Title: 
Clinical and Experimental Immunology

Immunodeficient mice bearing targeted mutations in the IL2rg gene and engrafted with human immune systems are effective tools for the study of human haematopoiesis, immunity, infectious disease and transplantation biology. The most robust human immune model is generated by implantation of human fetal thymic and liver tissues in irradiated recipients followed by intravenous injection of autologous fetal liver haematopoietic stem cells [often referred to as the BLT (bone marrow, liver, thymus) model].

Author(s): 
Covassin, L.
Jangalwe, S.
Jouvet, N.
Laning, J.
Burzenski, L.
Shultz, L. D.
Brehm, M. A.
Publication Title: 
Birth Defects Original Article Series
Author(s): 
Makinodan, T.
Publication Title: 
Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association

BACKGROUND: Chronic kidney disease (CKD) seems to be common in long-term survivors of haematopoietic cell transplantation (HCT). However, the range of its frequency is very wide, likely due to variability in the definitions of CKD and the periods of follow-up. METHODS: We conducted a cross-sectional and retrospective study in 158 adults who received myeloablative allogeneic HCT for lymphohaematologic malignancies at least 3 years ago and are alive today. The mean survival time was 6.15 +/- 4.88 years (range: 3-16 years).

Author(s): 
Ando, Minoru
Ohashi, Kazuteru
Akiyama, Hideki
Sakamaki, Hisashi
Morito, Taku
Tsuchiya, Ken
Nitta, Kosaku
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7-2.1-log reduction in viral load by treatment day 7, with a viral half-life of 0.9-1.9 days, indicating a highly effective block in viral replication.

Author(s): 
Shapira, Michael Y.
Resnick, Igor B.
Chou, Sunwen
Neumann, Avidan U.
Lurain, Nell S.
Stamminger, Thomas
Caplan, Orit
Saleh, Niveen
Efferth, Thomas
Marschall, Manfred
Wolf, Dana G.
Publication Title: 
Antiviral Research

The anti-malaria drug artesunate has been shown to be an effective inhibitor of cytomegalovirus (CMV) in vitro, in an experimental animal model, and in a recent single-case clinical use. In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness.

Author(s): 
Wolf, Dana G.
Shimoni, Avichai
Resnick, Igor B.
Stamminger, Thomas
Neumann, Avidan U.
Chou, Sunwen
Efferth, Thomas
Caplan, Orit
Rose, Jessica
Nagler, Arnon
Marschall, Manfred
Publication Title: 
Cancer Nursing

BACKGROUND: For over 2 decades, oncology nurses at a regional comprehensive cancer center offered sliced oranges to patients during the reinfusion of autologous hematopoietic progenitor cells (HPCs) to relieve symptoms associated with the preservative dimethyl sulfoxide (DMSO). OBJECTIVE: This randomized pilot study examined feasibility and efficacy of sliced orange intervention (OI), orange aromatherapy intervention (OAI), or deep breathing (control) to address unpleasant adverse effects during HPC infusion.

Author(s): 
Potter, Pamela
Eisenberg, Seth
Cain, Kevin C.
Berry, Donna L.
Publication Title: 
Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer

For many patients, a hematopoietic stem cell transplant (HSCT) can be challenging to physical and emotional health. Supportive care needs can be overwhelming for many patients and families. The purpose of this study was to evaluate the effect of quality of life (QOL), spiritual well-being, and supportive care resources post-HSCT. This descriptive, repeated-measures study included people over the age of 18 years undergoing HSCT for any cancer diagnosis.

Author(s): 
Sirilla, Janet
Overcash, Janine
Publication Title: 
Archives of Biochemistry and Biophysics

Mice lacking the vitamin D receptor (VDR) are resistant to airway inflammation. Pathogenic immune cells capable of transferring experimental airway inflammation to wildtype (WT) mice are present and primed in the VDR KO mice. Furthermore, the VDR KO immune cells homed to the WT lung in sufficient numbers to induce symptoms of asthma. Conversely, WT splenocytes, Th2 cells and hematopoetic cells induced some symptoms of experimental asthma when transferred to VDR KO mice, but the severity was less than that seen in the WT controls.

Author(s): 
Wittke, Anja
Chang, Andrew
Froicu, Monica
Harandi, Omid F.
Weaver, Veronika
August, Avery
Paulson, Robert F.
Cantorna, Margherita T.
Publication Title: 
Frontiers in Bioscience (Scholar Edition)

The incidence and prevalence of Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), are rising. According to some estimates >1 million new cases of IBD arise in the United States annually. The conventional therapies available for IBD range from anti-inflammatory drugs to immunosuppressive agents, but these therapies generally fail to achieve satisfactory results due to their side effects.

Author(s): 
Singh, Udai P.
Singh, Narendra P.
Singh, Balwan
Mishra, Manoj K.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Singh, Shree Ram

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