Heme Oxygenase-1

Publication Title: 
Current Neurovascular Research

HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6 KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.

Author(s): 
Guan, Xiaomei
Tu, Chao
Li, Mengjun
Hu, Zhiping
Publication Title: 
Laboratory Investigation; a Journal of Technical Methods and Pathology

The protective effect of heme oxygenase-1 (HO-1) expression in cardiovascular disease has been previously demonstrated using transgenic animal models in which HO-1 is constitutively overexpressed in the heart. However, the temporal requirements for protection by HO-1 induction relative to injury have not been investigated, but are essential to employ HO-1 as a therapeutic strategy in human cardiovascular disease states.

Author(s): 
Hull, Travis D.
Bolisetty, Subhashini
DeAlmeida, Angela C.
Litovsky, Silvio H.
Prabhu, Sumanth D.
Agarwal, Anupam
George, James F.
Publication Title: 
Journal of Biological Regulators and Homeostatic Agents

There is increasing evidence that psychosocial stress can be viewed as a system-wide derangement of cellular homeostasis, with heightened oxidative stress and triggered proinflammatory mechanisms. The aim of this study is twofold: a) to replicate findings that psychological stress increases oxidative damage and b) to determine whether a fermented papaya preparation known to exert significant protective antioxidant properties could buffer such increases in nuclear DNA damage while also inducing epigenetic protective mechanisms.

Author(s): 
Marotta, F.
Naito, Y.
Padrini, F.
Xuewei, X.
Jain, S.
Soresi, V.
Zhou, L.
Catanzaro, R.
Zhong, K.
Polimeni, A.
Chui, D. H.
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Analogs of the malaria therapeutic, artemisinin, possess in vitro and in vivo anticancer activity. In this study, two dimeric artemisinins (NSC724910 and 735847) were studied to determine their mechanism of action. Dimers were >1,000 fold more active than monomer and treatment was associated with increased reactive oxygen species (ROS) and apoptosis induction. Dimer activity was inhibited by the antioxidant L-NAC, the iron chelator desferroxamine and exogenous hemin.

Author(s): 
Stockwin, Luke H.
Han, Bingnan
Yu, Sherry X.
Hollingshead, Melinda G.
Elsohly, Mahmoud A.
Gul, Waseem
Slade, Desmond
Galal, Ahmed M.
Newton, Dianne L.
Bumke, Maja A.
Publication Title: 
Antimicrobial Agents and Chemotherapy

Severe forms of malaria infection, such as cerebral malaria (CM) and acute lung injury (ALI), are mainly caused by the apicomplexan parasite Plasmodium falciparum. Primary therapy with quinine or artemisinin derivatives is generally effective in controlling P. falciparum parasitemia, but mortality from CM and other forms of severe malaria remains unacceptably high. Herein, we report the design and synthesis of a novel carbon monoxide-releasing molecule (CO-RM; ALF492) that fully protects mice against experimental CM (ECM) and ALI.

Author(s): 
Pena, Ana C.
Penacho, Nuno
Mancio-Silva, Liliana
Neres, Rita
Seixas, João D.
Fernandes, Afonso C.
Romão, Carlos C.
Mota, Maria M.
Bernardes, Gonçalo J. L.
Pamplona, Ana
Publication Title: 
PloS One

Despite appropriate anti-malarial treatment, cerebral malaria (CM)-associated mortalities remain as high as 30%. Thus, adjunctive therapies are urgently needed to prevent or reduce such mortalities. Overproduction of CXCL10 in a subset of CM patients has been shown to be tightly associated with fatal human CM. Mice with deleted CXCL10 gene are partially protected against experimental cerebral malaria (ECM) mortality indicating the importance of CXCL10 in the pathogenesis of CM. However, the direct effect of increased CXCL10 production on brain cells is unknown.

Author(s): 
Wilson, Nana O.
Solomon, Wesley
Anderson, Leonard
Patrickson, John
Pitts, Sidney
Bond, Vincent
Liu, Mingli
Stiles, Jonathan K.
Publication Title: 
BMC genomics

BACKGROUND: Transcriptome analysis in combination with pathway-focused bioassays is suggested to be a helpful approach for gaining deeper insights into the complex mechanisms of action of herbal multicomponent preparations in living cells. The polyherbalism based concept of Tibetan and Ayurvedic medicine considers therapeutic efficacy through multi-target effects. A polyherbal Indo-Tibetan preparation, Padma 28, approved by the Swiss drug authorities (Swissmedic Nr. 58436), was applied to a more detailed dissection of mechanism of action in human hepatoma HepG2 cells.

Author(s): 
Klein, Angela
Wrulich, Oliver A.
Jenny, Marcel
Gruber, Peter
Becker, Kathrin
Fuchs, Dietmar
Gostner, Johanna M.
Uberall, Florian
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Curcumin is the main bioactive constituent derived from the rhizome of turmeric (Curcuma longa Linn.), which has been used traditionally as hepatoprotective agents in ayurvedic and traditional Chinese medicine for centuries. AIM OF THE STUDY: The present study was carried out to demonstrate the potential protective effect of curcumin pretreatment against ethanol-induced hepatocytes oxidative damage, with emphasis on heme oxygenase-1 (HO-1) induction.

Author(s): 
Bao, Wei
Li, Ke
Rong, Shuang
Yao, Ping
Hao, Liping
Ying, Chenjiang
Zhang, Xiping
Nussler, Andreas
Liu, Liegang
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Cissus quadrangularis is an ancient medicinal plant. It is an active ingredient of one Ayurvedic formula called "Laksha Gogglu". Its stem is used in food preparation in India. Traditionally it is used to treat various diseases like asthma, indigestion, ear diseases, irregular menstruation, skin diseases, piles, fractured bones, etc. AIM OF THE STUDY: This study aimed to evaluate the ability of the plant extracts to inhibit cycloxygenase (COX-1), cycloxygenase (COX-2), and 5-lipoxygenase (5-LOX) enzyme activity.

Author(s): 
Bhujade, Arti M.
Talmale, Suhas
Kumar, Naresh
Gupta, Geetika
Reddanna, P.
Das, Samar K.
Patil, M. B.
Publication Title: 
BMC genomics

BACKGROUND: Transcriptome analysis in combination with pathway-focused bioassays is suggested to be a helpful approach for gaining deeper insights into the complex mechanisms of action of herbal multicomponent preparations in living cells. The polyherbalism based concept of Tibetan and Ayurvedic medicine considers therapeutic efficacy through multi-target effects. A polyherbal Indo-Tibetan preparation, Padma 28, approved by the Swiss drug authorities (Swissmedic Nr. 58436), was applied to a more detailed dissection of mechanism of action in human hepatoma HepG2 cells.

Author(s): 
Klein, Angela
Wrulich, Oliver A.
Jenny, Marcel
Gruber, Peter
Becker, Kathrin
Fuchs, Dietmar
Gostner, Johanna M.
Uberall, Florian

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