We report the natural history, the clinical, radiological, echocardiographic and hemodynamic pattern of a living sixty-three year old man with tetralogy of Fallot and cyanosis since birth. We discuss the possible circulatory adaptations which allowed exceptional survival up to the seventh decade: it is the sixth case reported in the literature.
Zeitschrift F¸r Die Gesamte Innere Medizin Und Ihre Grenzgebiete
Proceeding from experiences with animal-experimental studies is tried to show all those mechanisms which have influence on the ageing process of man. In these cases in the experimental part of the study is particularly investigated the influence of the restriction of food in obese patients on the cardiovascular system, the lipid metabolism and the biological age. In obese patients of middle age by isocaloric reduction diet a normalisation of the at present changed non-invasive cardiodynamic parameters could be achieved.
The impact of treatment on prognosis of patients with chronic congestive heart failure depends not only on pharmacological therapy but also on nonpharmacological aspects of patient management. Patient compliance, life style changes, salt and fluid restriction, detailed patient information and measures of self control greatly affect therapeutic efficacy.
Epidemiological data have linked an adverse fetal environment with increased risks of cardiovascular, metabolic, neuroendocrine, and psychiatric disorders in adulthood. Prenatal stress and/or glucocorticoid excess might underlie this link.
INTRODUCTION: Brain imaging is becoming a powerful tool in the study of human cerebral functions related to close personal relationships. Outside of subcortical structures traditionally thought to be involved in reward-related systems, a wide range of neuroimaging studies in relationship science indicate a prominent role for different cortical networks and cognitive factors.
KB-509, a new derivative of benzodiazepines, increased locomotor activities of mice in doses of 8-32 mg/kg (p.o.) and a decrease occurred with higher doses. This drug was 3-6 and 1-2 times more potent than diazepam (DZP) and nitrazepam (NZP), respectively, in anticonvulsant (anti-pentylenetetrazol, bemegride, strychnine) activities, antiaggressive activity and potentiation of chlorprothixene-induced hypnosis in mice.
Propane-1,2-diol (propylene glycol, PG), considered to be a safe solvent and commonly used as a vehicle in pharmacological and toxicological investigations, showed various neuropsychopharmacological activity in albino mice and rats. In lower concentrations (10-20%), at dose level of 10 ml/kg, PG did not show any significant neuropsychopharmacological activity either by i.p. or p.o. routes. But higher concentrations (50-100%), at same dose level by i.p. route, were found to have moderate to marked effect.
In an attempt to separate the somatic and mental components of stress, groups of young male volunteers underwent running exercises and sauna baths, and roughly one year later had the same experiences recalled under hypnosis. In addition, experiments involving mental stress in the form of mental arithmetic were performed. A variety of physiological and biochemical parameters was measured on each occasion. Results for cardiovascular responses, renin-angiotensin-aldosterone, cortisol, testosterone, androstenedione, prolactin and growth hormone are reported.