Publication Title: 
Acta Poloniae Pharmaceutica

The present investigation was an attempt to evaluate the anti-inflammatory effect of a polyherbal preparation (Sudarshanam Oil) on hematological parameters in Wistar rats. This polyherbal formula contains main ingredients of Tinaspora Cordifolia, Curcuma longa, Terminalia chebula, Emblica officinalis, Andrographis paniculata and Terminalia belerica. The active phytochemicals such as tannins, glycosides, flavonoids and triterpenoids are extracted from these herbal plants. And extract was prepared in corn oil.

Patel, Chintan D.
Modi, Vandana D.
Chakraborty, Bhaswat S.
Mathuria, Neeta
Dadhaniya, Paresh
Borade, Prasad A.
Morankar, Pravin
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To assess whether familial longevity can be attributed to sustained hematopoietic capacity. DESIGN: Prospective follow-up study of two independent population-based cohorts. SETTING: The Leiden Longevity Study and the Leiden 85-plus Study. PARTICIPANTS: From the Leiden Longevity Study, 1,001 nonagenarians with familial longevity were included. As age-matched controls, 260 nonagenarians without familial longevity were used from the Leiden 85-plus Study. MEASUREMENTS: Hemoglobin, leukocytes, and thrombocytes were measured for all subjects with and without familial longevity.

Willems, Jorien M.
Trompet, Stella
Eline Slagboom, P.
de Craen, Anton J. M.
Westendorp, Rudi G. J.
Publication Title: 
British Medical Journal
Hobson, W.
Blackburn, E. K.
Publication Title: 
Brain Research

Grandmaternal love is essential for the grandmotherñgrandchild attachment relationship and thus aids an infant's development and mental health, but the underlying neural mechanism is unknown. Recent studies have shed light on involvement of the prefrontal cortex (PFC) in maternal and romantic love. Here, we investigated the involvement of the PFC in grandmaternal love by examining cerebral hemoglobin concentration changes using near-infrared spectroscopy (NIRS).

Kida, Tetsuo
Nishitani, Shota
Tanaka, Masanori
Takamura, Tsunehiko
Sugawara, Masashi
Shinohara, Kazuyuki
Publication Title: 
The Journal of Biological Chemistry

Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria. Rational drug design based on artemisinin and its analogues is slow as the mechanism of action of these antimalarials is not clear. Here we report that these drugs, at least in part, exert their effect by interfering with the plasmodial hemoglobin catabolic pathway and inhibition of heme polymerization. In an in vitro experiment we observed inhibition of digestive vacuole proteolytic activity of malarial parasite by artemisinin.

Pandey, A. V.
Tekwani, B. L.
Singh, R. L.
Chauhan, V. S.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. In view of concern about the potential long-term toxicity, rats were treated orally with 80 mg/kg artemether once every 2 weeks for 5 months. After the final treatment, routine blood test results were normal except for reversible reductions of reticulocyte counts and reversible increases in hemoglobin levels.

Xiao, Shuhua
Yang, Yuanqing
You, Qiqing
Utzinger, Jürg
Guo, Huifang
Peiying, Jiao
Mei, Jinying
Guo, Jian
Bergquist, Robert
Tanner, Marcel
Publication Title: 
Antimicrobial Agents and Chemotherapy

Endocytosis is a fundamental process of eukaryotic cells and fulfills numerous functions, most notably, that of macromolecular nutrient uptake. Malaria parasites invade red blood cells and during their intracellular development endocytose large amounts of host cytoplasm for digestion in a specialized lysosomal compartment, the food vacuole. In the present study we have examined the effects of artemisinin and the quinoline drugs chloroquine and mefloquine on endocytosis in Plasmodium falciparum.

Hoppe, Heinrich C.
van Schalkwyk, Donelly A.
Wiehart, Ursula I. M.
Meredith, Sandra A.
Egan, Joanne
Weber, Brandon W.
Publication Title: 
The Biochemical Journal

Elucidation of the principal targets of the action of the antimalarial drug artemisinin is an ongoing pursuit that is important for understanding the action of this drug and for the development of more potent analogues. We have examined the chemical reaction of Hb with artemisinin. The protein-bound haem in Hb has been found to react with artemisinin much faster than is the case with free haem.

Kannan, Rangiah
Kumar, Krishan
Sahal, Dinkar
Kukreti, Shrikant
Chauhan, Virander S.
Publication Title: 
FEBS letters

The role of haem iron (II) and oxidative stress in the activation and antimalarial activity of artemisinin is unclear. Thus, we submitted malaria parasite to modified culture conditions: artemisinin activity increased by 20-30% under an oxygen-rich atmosphere (20% O2 instead of "standard" 1% O2), and by 40-50% in the presence of carboxy-haemoglobin, and 2% carbon monoxide, conditions which inhibit haem iron (II) reactivity. In all cases, parasite growth and chloroquine activity were unaffected.

Parapini, Silvia
Basilico, Nicoletta
Mondani, Monica
Olliaro, Piero
Taramelli, Donatella
Monti, Diego
Publication Title: 
Tropical medicine & international health: TM & IH

Multi-drug resistant falciparum malaria is widespread in Asia. In Thailand, Cambodia and Vietnam the national protocols have changed largely to artesunate combined treatment regimens but elsewhere in East and South Asia chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are still widely recommended by national malaria control programmes.

Smithuis, Frank
Shahmanesh, Maryam
Kyaw, Moe Kyaw
Savran, Olivia
Lwin, Saw
White, Nicholas J.


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