Publication Title: 
Journal of Ethnopharmacology

A total of 82 Indian medicinal plants traditionally used in medicines were subjected to preliminary antibacterial screening against several pathogenic and opportunistic microorganisms. Aqueous, hexane and alcoholic extracts of each plant were tested for their antibacterial activity using agar well diffusion method at sample concentration of 200 mg/ml. The results indicated that out of 82 plants, 56 exhibited antibacterial activity against one or more test pathogens.

Ahmad, I.
Mehmood, Z.
Mohammad, F.
Publication Title: 
Drugs Under Experimental and Clinical Research

Allergic rhinitis, a frequently occurring immunological disorder affecting men, women and children worldwide, is a state of hypersensitivity that occurs when the body overreacts to a substance such as pollen, mold, mites or dust. Allergic rhinitis exerts inflammatory response and irritation of the nasal mucosal membranes leading to sneezing; stuffy/runny nose; nasal congestion; and itchy, watery and swollen eyes.

D'Souza, P.
Amit, A.
Saxena, V. S.
Bagchi, D.
Bagchi, M.
Stohs, S. J.
Publication Title: 
Methods and Findings in Experimental and Clinical Pharmacology

In search of broad-spectrum antibacterial activity from traditionally used Indian medicinal plants, 66 ethanolic plant extracts were screened against nine different bacteria. Of these, 39 extracts demonstrated activity against six or more test bacteria. Twelve extracts showing broad-spectrum activity were tested against specific multidrug-resistant (MDR) bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and extended spectrum beta-lactamases (ESbetaL)-producing enteric bacteria.

Aqil, F.
Ahmad, I.
Publication Title: 
International Journal of Cosmetic Science

The hydroglycolic (HG) extract from 70% propylene glycol (PG) extraction of myrobalan fruits showed the most appreciable antioxidant efficiency towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) in comparison to the extracts from 30, 50, 70 and 100% ethyl alcohol (EA), and 30, 50 and 100% PG . Its total polyphenols were also higher than others. The additional analysis of antioxidant power revealed that this HG extract was able to counteract the induced oxidation caused by hydrogen peroxide (H(2) O(2) ) and 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH).

Chulasiri, M.
Wanaswas, P.
Sriaum, D.
Nakamat, S.
Wongkrajang, Y.
Kongsaktrakoon, B.
Phornchirasilp, S.
Songchitsomboon, S.
Leelarungrayub, D.
Publication Title: 
Indian Journal of Pharmacology

OBJECTIVES: To evaluate the antioxidant and free-radical scavenging activities of triethylchebulate (TCL), an aglycone isolated from the fruit of Terminalia chebula Retz. MATERIALS AND METHODS: Microsomes, mitochondria and red blood cells (RBCs) were isolated from rat liver. The antioxidant capacities were evaluated by determining the inhibitory effects of TCL on lipid peroxidation, hydrogen peroxide (H(2)O(2))-induced RBCs hemolysis and RBCs autoxidative hemolysis.

Chen, Xiuping
Sun, Fangyun
Ma, Lifeng
Wang, Jinhua
Qin, Hailin
Du, Guanhua
Publication Title: 
Pharmaceutical Biology

CONTEXT: Arthritis is inflammation of one or more joints. Terminalia chebula Retz. (Combretaceae) fruit is mentioned in Ayurveda as useful in treating arthritic disorders. OBJECTIVE: This work was undertaken to evaluate the anti-inflammatory, antioxidant, anti-lipid peroxidative and membrane-stabilizing effects of hydroalcoholic extract of Terminalia chebula fruits and also to establish a possible association between them. MATERIALS AND METHODS: In vivo anti-inflammatory activity of T. chebula fruit extract at different doses ranged from 50 to 500?mg/kg, p.o.

Bag, Anwesa
Kumar Bhattacharyya, Subir
Kumar Pal, Nishith
Ranjan Chattopadhyay, Rabi
Publication Title: 
The Japanese Journal of Antibiotics

General pharmacological studies on T-1982 produced the following results. On central nervous system, subcutaneous injection of T-1982 at dose of 2,000 mg/kg hastened the onset of pentetrazole-induced tonic extensor in mice. T-1982 had no effect on spontaneous motor activity, pentobarbital hypnosis, body temperature or EEG in mice or rabbits, and also did not show motor incoordinate, anticonvulsive or analgesic activity in mice at intravenous doses of 250--1,000 mg/kg or subcutaneous doses of 500--2,000 mg/kg.

Takai, A.
Hirai, S.
Watanabe, I.
Hiraiwa, T.
Abe, N.
Arai, H.
Omori, M.
Tanada, K.
Senda, N.
Hashiba, K.
Matsukura, K.
Takata, K.
Okami, H.
Publication Title: 
Acta Pharmacologica Sinica

AIM: To study the immunosuppressive activity of SM735 {[3-(12-beta-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal anti-inflammatory drug structure, with the aim of finding potential immunosuppressive agents. METHODS: Concanavalin A (ConA), lipopolysaccharide (LPS), and mixed lymphocyte reaction (MLR), were used to induce the proliferation of splenocytes, and [3H]-thymidine incorporation was used to evaluate the proliferation of splenocytes.

Zhou, Wen-liang
Wu, Jin-ming
Wu, Qing-Li
Wang, Jun-Xia
Zhou, Yu
Zhou, Ru
He, Pei-Lan
Li, Xiao-yu
Yang, Yi-fu
Zhang, Yu
Li, Ying
Zuo, Jian-ping
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

This multi-center, randomized, parallel-group, double-blind, double-dummy study compared the efficacy and safety of chlorproguanil-dapsone-artesunate (CDA) and chlorproguanil-dapsone (CPG-DDS) in the treatment of falciparum malaria in Africa (Burkina Faso, Ghana, Mali, Nigeria). Six hundred patients (>or= 1 year of age) received CDA 2.0/2.5/4.0 mg/kg, and 292 CPG-DDS 2.0/2.5 mg/kg, once daily for 3 days.

Tiono, Alfred B.
Dicko, Alassane
Ndububa, Dennis A.
Agbenyega, Tsiri
Pitmang, Simon
Awobusuyi, Jacob
Pamba, Allan
Duparc, Stephan
Goh, Li-Ean
Harrell, Emma
Carter, Nick
Ward, Stephen A.
Greenwood, Brian
Winstanley, Peter A.
Publication Title: 
Antimicrobial Agents and Chemotherapy

The current interest in malaria elimination has led to a renewed interest in drugs that can be used for mass administration to minimize malaria transmission. Primaquine (PQ) is the only generally available drug with a strong activity against mature Plasmodium falciparum gametocytes, the parasite stage responsible for transmission. Despite concerns about PQ-induced hemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals, a single dose of PQ may be safe and efficacious in clearing gametocytes that persist after conventional treatment.

Shekalaghe, Seif A.
ter Braak, Roel
Daou, Modibo
Kavishe, Reginald
van den Bijllaardt, Wouter
van den Bosch, Sven
Koenderink, Jan B.
Luty, Adrian J. F.
Whitty, Christopher J. M.
Drakeley, Chris
Sauerwein, Robert W.
Bousema, Teun


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