Heparin

Publication Title: 
Aktuelle Urologie

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures.

Author(s): 
Binder, I.
Rossbach, G.
van Ophoven, A.
Publication Title: 
Aktuelle Urologie

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures.

Author(s): 
Binder, I.
Rossbach, G.
van Ophoven, A.
Publication Title: 
Journal of Clinical Pathology

Eight patients with E. coli septicaemia had oliguric renal failure which was associated with haematological evidence of intravascular coagulation. Five of these patients also had the characteristic blood picture of microangiopathic haemolytic anaemia. In an attempt to prevent further deposition of fibrin, intravenous heparin was administered to six patients, three of whom recovered fully and three died. The diagnosis of intravascular coagulation was subsequently confirmed by histological examination of necropsy material and it is suggested that some of the complications of E.

Author(s): 
Preston, F. E.
Malia, R. G.
Sworn, M. J.
Blackburn, E. K.
Publication Title: 
Thrombosis and Haemostasis

Evidence has been sought of activation of the coagulation system in two groups of patients following the infusion of two heparinised clotting factor concentrates. No changes were detected in 13 patients with mild hepatic dysfunction. In six studies on patients with Christmas disease induced abnormalities occurred in only one. Activation of the coagulation mechanism did not occur in another individual who had received the same batch of material.

Author(s): 
Preston, F. E.
Malia, R. G.
Lilleyman, J. S.
Blackburn, E. K.
Publication Title: 
Medical Science
Author(s): 
Erslev, A. J.
Publication Title: 
Clinical Obstetrics and Gynecology

Drugs used in the management of pregnancy-induced hypertension have been reviewed, and their value and adverse effects on both mother and fetus have been considered. Although magnesium and hydralazine remain the stalwarts of therapy, a number of other drugs have potential that may be realized in the future. Several new medications have promise in correcting the derangements of toxemia, but safety for the fetus has yet to be demonstrated.

Author(s): 
Kelly, J. V.
Publication Title: 
[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai

A 53-year-old woman who had severe mitral regurgitation associated with moderate tricuspid regurgitation and mild aortic regurgitation underwent mitral valve replacement with a 27 mm Björk-Shiley mechanical valve, left atrial plication and tricuspid annuloplasty. She fell into low output syndrome on the first postoperative day because of persistent intractable ventricular arrhythmia and eventually required open cardiac massage. The left ventricular (LV) bypass using a centrifugal pump was initiated with cannulation to ascending aorta and left atrium.

Author(s): 
Chang, J. C.
Matsuda, H.
Kadoba, K.
Kaneko, M.
Mitsuno, M.
Kawashima, Y.
Publication Title: 
Intensive Care Medicine

OBJECTIVE: Successful resuscitation of the brain requires complete microcirculatory reperfusion, which, however, may be impaired by activation of blood coagulation after cardiac arrest. The study addresses the question of whether postischemic thrombolysis is effective in reducing cerebral no-reflow phenomenon. DESIGN: 14 adult normothermic cats were submitted to 15-min cardiac arrest, followed by cardiopulmonary resuscitation (CPR) and 30 min of spontaneous recirculation.

Author(s): 
Fischer, M.
Böttiger, B. W.
Popov-Cenic, S.
Hossmann, K. A.
Publication Title: 
Klinische Monatsblätter Für Augenheilkunde

BACKGROUND: Goal of our study was the comparison of the efficacy of various minimal invasive therapeutic regimens for clinically complete central retinal artery occlusion (CRAO) and the comparison with the literature. PATIENTS AND METHODS: In a retrospective study 93 patients treated for CRAO during the period 1994-1998 were identified. 65 of these patients with clinically complete occlusion without a cilioretinal artery were included in the study. Analysis focused on the results of different therapies and the duration of visual impairment till starting treatment.

Author(s): 
Neubauer, A. S.
Mueller, A. J.
Schriever, S.
Grüterich, M.
Ulbig, M.
Kampik, A.
Publication Title: 
The Journal of Biological Chemistry

Fibroblast growth factors are key proteins in many intercellular signaling networks. They normally remain attached to the extracellular matrix, which confers on them a considerable stability. The unrestrained accumulation of fibroblast growth factors in the extracellular milieu, either due to uncontrolled synthesis or enzymatic release, contributes to the pathology of many diseases. Consequently, the neutralization of improperly mobilized fibroblast growth factors is of clear therapeutic interest.

Author(s): 
Fernández, Israel S.
Cuevas, Pedro
Angulo, Javier
López-Navajas, Pilar
Canales-Mayordomo, Angeles
González-Corrochano, Rocío
Lozano, Rosa M.
Valverde, Serafín
Jiménez-Barbero, Jesús
Romero, Antonio
Giménez-Gallego, Guillermo

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