Hepatitis B virus

Publication Title: 
Acupuncture & Electro-Therapeutics Research

The purpose of this work was to evaluate the quality of randomized controlled trials (RCTs) with acupuncture treatment for hepatitis B virus (HBV) infection. A systematic review of the literature for clinical trials was performed up to September 2008. RCTs assessing acupuncture point stimulation for patients with HBV infection were considered for inclusion. The search identified 70 relevant trials meeting the inclusion.

Author(s): 
Zheng, Shumei
Du, Juan
Lu, Xiaoqin
Zhang, Yajun
Hu, Lisheng
Wang, Wei
Publication Title: 
Phytotherapy research: PTR

The antiviral effects of aqueous extracts of Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. were examined by a cell culture system using a hepatitis B virus (HBV) producing cell line, HepG2 2.2.15. The extracts were assayed for the inhibition of HBV multiplication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells after an 8-day treatment.

Author(s): 
Kim, T. G.
Kang, S. Y.
Jung, K. K.
Kang, J. H.
Lee, E.
Han, H. M.
Kim, S. H.
Publication Title: 
Methods in Molecular Biology (Clifton, N.J.)

Chronic hepatitis B remains a substantial public health burden affecting approximately 350 million people worldwide, causing cirrhosis and liver cancer, and about 1 million people die each year from hepatitis B and its complications. Hepatitis B is caused by hepatitis B virus (HBV) infection. As an essential component of the viral life cycle, HBV covalently closed circular DNA (cccDNA) is synthesized and maintained at low copy numbers in the nucleus of infected hepatocytes, and serves as the transcription template for all viral RNAs.

Author(s): 
Cai, Dawei
Nie, Hui
Yan, Ran
Guo, Ju-Tao
Block, Timothy M.
Guo, Haitao
Publication Title: 
Indian Journal of Pathology & Microbiology

BACKGROUND: Patients with thalassemia major are largely transfusion dependent and are thus exposed to a variety of risks such as transmission of infectious diseases, iron overload and alloimmunization. This study was performed to determine the prevalence of human immune deficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and red cell antibodies among multiple-transfused thalassemic patients in and around the national capital region.

Author(s): 
Makroo, Raj Nath
Arora, Jatinder Singh
Chowdhry, Mohit
Bhatia, Aakanksha
Thakur, Uday Kumar
Minimol, Antony
Publication Title: 
Acta Pharmacologica Sinica

Hepatitis B virus (HBV) or hepatitis C virus (HCV) infections are a major threat worldwide. Combination therapy of interferon-alpha and ribavirin is currently the treatment of choice for HCV-infected patients. However, this regimen is only effective in approximately 50% of patients and provokes severe side-effects. Numerous natural alternatives for treating HCV have been suggested. Deoxynojirimycin and its derivatives are iminosugars which exert anti-HCV activity by inhibiting alpha-glucosidases.

Author(s): 
Wohlfarth, Carolin
Efferth, Thomas
Publication Title: 
Bioscience Trends

Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China and widely used for hepatitis B in China and many parts of the world.

Author(s): 
Cui, Xiaoyan
Wang, Yueling
Kokudo, Norihiro
Fang, Dingzhi
Tang, Wei
Publication Title: 
Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
Author(s): 
Tu, Yan-yun
Qiu, Hai-xian
Publication Title: 
Biological & Pharmaceutical Bulletin

The ethanol extract of Geranium carolinianum L., a domestic plant grown in China, was subjected to sequential extractions with different organic solvents. The extracts were assayed for anti-hepatitis B virus (HBV) activities. The ethyl acetate fraction was found to contain the highest level of anti-HBV activity. In order to identify the active ingredients, the ethyl acetate fraction was further fractionated by column chromatography.

Author(s): 
Li, Jiyang
Huang, Hai
Zhou, Wei
Feng, Meiqing
Zhou, Pei
Publication Title: 
Journal of Virology

Nuclear receptors have a unique role in governing hepatitis B virus (HBV) transcription and replication. Hepatocyte nuclear factor 4alpha (HNF4alpha) and retinoid X receptor alpha (RXRalpha) plus peroxisome proliferator-activated receptor alpha (PPARalpha) have been shown to support viral biosynthesis in nonhepatoma cells in the absence of additional liver-enriched transcription factors. However, the in vivo importance of these nuclear receptors in HBV biosynthesis has been investigated only to a limited extent.

Author(s): 
Li, Lie
Oropeza, Claudia E.
Kaestner, Klaus H.
McLachlan, Alan
Publication Title: 
World journal of gastroenterology: WJG

AIM: This study aims at exploring the distribution of TCM syndromes in CHB patients with HBV pre-core mutation (1896) and the relationship between pre-core mutation and T lymphocytes subgroup, through which to provide objective data on clinical syndrome differentiation of TCM, and further to suggest the therapeutic principle and guide clinical treatment. METHODS: One hundred and forty CHB patients were evenly divided into two study groups, HBV pre-core mutant group and HBV pre-core wild-type group. Besides, 30 healthy blood donors were selected as a healthy control group.

Author(s): 
Yang, Hong-Zhi
Zhao, Jian-An
Dai, Min
Li, Yong-Wei
Wang, Yong-Ze
Guan, Wei-Bing
Xie, He-Ping

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