Hepatocyte Growth Factor

Publication Title: 
Psychotherapy and Psychosomatics
Author(s): 
Kovács, Z. A.
Puskás, L. G.
Juhász, A.
Rimanóczy, A.
Hackler, L.
Kátay, L.
Gali, Z.
Vetró, A.
Janka, Z.
Kálmán, J.
Publication Title: 
Journal of the American Society of Nephrology: JASN

Recent studies show that hepatocyte growth factor (HGF) has potent anti-inflammatory effects in multiple animal models of disease in various organ systems, including the kidney, suggesting that HGF may suppress a common proinflammatory process. The aim of this study was to examine the molecular mechanism of HGF's anti-inflammatory actions in a model of chronic kidney disease.

Author(s): 
Gong, Rujun
Rifai, Abdalla
Dworkin, Lance D.
Publication Title: 
The Journal of Biological Chemistry

Activation of NFkappaB is a fundamental cellular event central to all inflammatory diseases. Hepatocyte growth factor (HGF) ameliorates both acute and chronic inflammation in a multitude of organ systems through modulating NFkappaB activity; nevertheless, the exact molecular mechanism remains uncertain. Here we report that HGF through inactivation of GSK3beta suppresses NFkappaB p65 phosphorylation specifically at position Ser-468.

Author(s): 
Gong, Rujun
Rifai, Abdalla
Ge, Yan
Chen, Shan
Dworkin, Lance D.
Publication Title: 
Hepatology (Baltimore, Md.)

Epithelial-to-mesenchymal transition (EMT) is predicted to play a critical role in metastatic disease in hepatocellular carcinoma. In this study, we used a novel murine model of EMT to elucidate a mechanism of tumor progression and metastasis. A total of 2 x 10(6) liver cells isolated from Pten(loxp/loxp)/Alb-Cre(+) mice, expanded from a single CD133(+)CD45(-) cell clone, passage 0 (P0), were sequentially transplanted to obtain two passages of tumor cells, P1 and P2. Cells were analyzed for gene expression using microarray and real-time polymerase chain reaction.

Author(s): 
Ding, Wei
You, Hanning
Dang, Hien
LeBlanc, Francis
Galicia, Vivian
Lu, Shelly C.
Stiles, Bangyan
Rountree, C. Bart
Publication Title: 
Current Opinion in Rheumatology

PURPOSE OF REVIEW: Racial disparities appear to exist in the susceptibility and severity of systemic sclerosis (SSc, scleroderma) and are responsible for a greater health burden in blacks as compared with whites. Disparities in socioeconomic status and access to healthcare do not sufficiently explain the observed differences in prevalence and mortality. It is important to determine whether there might be a biologic basis for the racial disparities observed in SSc.

Author(s): 
Silver, Richard M.
Bogatkevich, Galina
Tourkina, Elena
Nietert, Paul J.
Hoffman, Stanley
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To study the effect of Kangxianling Decoction (KXLD), a compound traditional Chinese herbal medicine, on expression of hepatocyte growth factor (HGF) mRNA and phosphorylations of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) and p38 in renal tissue of rats with unilateral ureteral obstruction (UUO). METHODS: Eighteen male SD rats were randomly divided into 3 groups: sham-operated group, untreated group and KXLD-treated group. A rat model of renal interstitial fibrosis was established by UUO.

Author(s): 
Zhang, Yue
Liu, Yu-Min
Lu, Hai-ying
Liu, Ke-jian
Li, Jing
He, Li-qun
Lin, Min
Zhou, Li
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