Herpesvirus 1, Human

Publication Title: 
Antiviral Research

Traditional herbal medicines have been safely used for the treatment of various human diseases since ancient China. We selected 10 herbal extracts with therapeutic antiherpes simplex virus type 1 (HSV-1) activity. Among these, Geum japonicum Thunb., Rhus javanica L., Syzygium aromaticum (L.) Merr. et Perry, or Terminalia chebula Retzus showed a stronger anti-HSV-1 activity in combination with acyclovir than the other herbal extracts in vitro.

Kurokawa, M.
Nagasaka, K.
Hirabayashi, T.
Uyama, S.
Sato, H.
Kageyama, T.
Kadota, S.
Ohyama, H.
Hozumi, T.
Namba, T.
Publication Title: 
Journal of Virology

Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that chebulagic acid (CHLA) and punicalagin (PUG), two hydrolyzable tannins isolated from the dried fruits of Terminalia chebula Retz. (Combretaceae), inhibit HSV-1 entry at noncytotoxic doses in A549 human lung cells.

Lin, Liang-Tzung
Chen, Ting-Ying
Chung, Chueh-Yao
Noyce, Ryan S.
Grindley, T. Bruce
McCormick, Craig
Lin, Ta-Chen
Wang, Guey-Horng
Lin, Chun-Ching
Richardson, Christopher D.
Publication Title: 
Sexually Transmitted Infections

OBJECTIVE: To develop a new, rapid, and convenient technique for the diagnosis and typing of herpes simplex virus (HSV) in genital herpes (GH). METHODS: Using samples from skin vesicle fluid and urogenital mucosal swabs of subjects with GH, conventional polymerase chain reaction (PCR) (directed to polymerase gene: PCRpG) were compared with a newly developed PCR (directed to HSV glycoprotein gene: PCRgG). Both PCR methods were compared with virus isolation culture (VI) with indirect immunofluorescent staining (IIF). RESULTS: 80 samples from 40 GH patients (25 males) were tested.

Fang, X. F.
Song, B.
Tu, Y. Y.
Tong, J. Z.
Faul, J. L.
Bai, H.
Publication Title: 
Antiviral Research

Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection. Therefore, the discovery of novel anti-HSV drugs deserves great efforts. In this paper, we review anti-HSV substances from natural sources, including both extracts and pure compounds from herbal medicines, reported in studies from several laboratories. The role of traditional medicine for the development of anti-HSV compounds is also discussed.

Khan, Mahmud Tareq Hassan
Ather, Arjumand
Thompson, Kenneth D.
Gambari, Roberto
Publication Title: 
Microbiological Research

The aim of this study was to evaluate the antiviral potential of methanolic extract (ME) of Achyranthes aspera, an Indian folk medicine and one of its pure compound oleanolic acid (OA) against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The ME possessed weak anti-herpes virus activity (EC50 64.4μg/ml for HSV-1 and 72.8μg/ml for HSV-2). While OA exhibited potent antiherpesvirus activity against both HSV-1 (EC50 6.8μg/ml) and HSV-2 (EC50 7.8μg/ml). The time response study revealed that the antiviral activity of ME and OA is highest at 2-6h post infection.

Mukherjee, Hemanta
Ojha, Durbadal
Bag, Paromita
Chandel, Himanshu Singh
Bhattacharyya, Souvik
Chatterjee, Tapan K.
Mukherjee, Pulok K.
Chakraborti, Sekhar
Chattopadhyay, Debprasad
Publication Title: 
Chemical & Pharmaceutical Bulletin

The root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In this study, we found a new lignan glycoside (6) and two new phenylethanoid glycosides (7, 8) together with five known compounds as chemical constituents of Strobilanthes cusia root. Some samples were examined for anti-herpes simplex virus type-1 (HSV-1) activity.

Tanaka, Tomonori
Ikeda, Tsuyoshi
Kaku, Miho
Zhu, Xing-Hua
Okawa, Masafumi
Yokomizo, Kazumi
Uyeda, Masaru
Nohara, Toshihiro
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