Heterogeneous-Nuclear Ribonucleoproteins

Publication Title: 
PloS One

BACKGROUND: Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.

Author(s): 
Dwivedi, Vibha
Anandan, E. M.
Mony, Rajesh S.
Muraleedharan, T. S.
Valiathan, M. S.
Mutsuddi, Mousumi
Lakhotia, Subhash C.
Publication Title: 
The Journal of Biological Chemistry

Human TDP-43 represents the main component of neuronal inclusions found in patients with neurodegenerative diseases, especially frontotemporal lobar degeneration and amyotrophic lateral sclerosis. In vitro and in vivo studies have shown that the TAR DNA-binding protein 43 (TDP-43) Drosophila ortholog (TBPH) can biochemically and functionally overlap the properties of the human factor.

Author(s): 
Romano, Maurizio
Buratti, Emanuele
Romano, Giulia
Klima, Raffaella
Del Bel Belluz, Lisa
Stuani, Cristiana
Baralle, Francisco
Feiguin, Fabian
Publication Title: 
PloS One

BACKGROUND: Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.

Author(s): 
Dwivedi, Vibha
Anandan, E. M.
Mony, Rajesh S.
Muraleedharan, T. S.
Valiathan, M. S.
Mutsuddi, Mousumi
Lakhotia, Subhash C.
Publication Title: 
PloS One

BACKGROUND: Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.

Author(s): 
Dwivedi, Vibha
Anandan, E. M.
Mony, Rajesh S.
Muraleedharan, T. S.
Valiathan, M. S.
Mutsuddi, Mousumi
Lakhotia, Subhash C.
Publication Title: 
PloS One

BACKGROUND: Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.

Author(s): 
Dwivedi, Vibha
Anandan, E. M.
Mony, Rajesh S.
Muraleedharan, T. S.
Valiathan, M. S.
Mutsuddi, Mousumi
Lakhotia, Subhash C.
Publication Title: 
Journal of Lipid Research

The 3'untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization induced by berberine (BBR). However, the identities of the specific RNA binding proteins involved in the regulation of LDLR mRNA stability at the steady state level or upon BBR treatment are unknown.

Author(s): 
Li, Hai
Chen, Wei
Zhou, Yue
Abidi, Parveen
Sharpe, Orr
Robinson, William H.
Kraemer, Fredric B.
Liu, Jingwen
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