Publication Title: 
Archives Italiennes De Biologie
Carli, G.
Publication Title: 
Neuroscience and Behavioral Physiology

The influence of the state of "animal hypnosis" in rabbits on the course and preservation of the motor polarizational dominant created by the action of a direct current anode on the region of the sensorimotor cortex was investigated. The mechanogram of both forelimbs was recorded. It was demonstrated that the state of "animal hypnosis" induced against the background of the optimum of the dominant inhibits the motor reaction of the "dominant" limb to sensory test stimuli. This inhibition is maintained for a long time, up to two to four days.

Rusinova, E. V.
Publication Title: 
International Review of Neurobiology

Despite the increasing use of aromatherapy oils, there have not been many studies exploring the biological activities of bergamot (Citrus bergamia, Risso) essential oil (BEO). Recently, we have investigated the effects of BEO injected into the plantar surface of the hindpaw in the capsaicin test in mice. The intraplantar injection of capsaicin produced an intense and short-lived licking/biting response toward the injected hindpaw. The capsaicin-induced nociceptive response was reduced significantly by intraplantar injection of BEO.

Sakurada, Tsukasa
Kuwahata, Hikari
Katsuyama, Soh
Komatsu, Takaaki
Morrone, Luigi Antonio
Corasaniti, Maria Tiziana
Bagetta, Giacinto
Sakurada, Shinobu
Publication Title: 
Journal of Ethnopharmacology

The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, i.e. extracts from Ashwagandha, Withania somnifera (L.) Dunal (Solanaceae), namely WST and WS2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (DTH). Immunomodulatory effect was assessed in If IgE-mediated anaphylaxis as reduction of ovalbumin-induced paw edema, in animals treated with WS2 at doses of 150 and 300 mg/kg, and the results were compared with the standard drug disodium chromoglycate.

Agarwal, R.
Diwanay, S.
Patki, P.
Patwardhan, B.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Caesalpinia bonducella FLEMING (Caesalpiniaceae) plant is well known for its medicinal and therapeutic values in Indian Ayurveda. However, to be clinically useful, more scientific data are needed. Therefore, in the present study, we investigated the effects of C. bonducella seed oil on acute and chronic inflammation. To assess the anti-inflammatory, antipyretic and analgesic activities, varied concentrations of the seed oil of C.

Shukla, Shruti
Mehta, Archana
Mehta, Pradeep
Vyas, Suresh Prasad
Shukla, Savita
Bajpai, Vivek K.
Publication Title: 
Toxicon: Official Journal of the International Society on Toxinology

The Indian Monocellate Cobra venom (NKV) showed anti-arthritic activity over FCA induced arthritis in male albino rats. NKV treatment (1/20th & 1/10th MLD doses x 13 days, i.p.) showed significant restoration in paw & ankle volume, paw weight. Urinary hydroxyproline, glucosamine, serum ACP, ALP and IL-10 level were restored significantly, due to NKV treatment, as compared with arthritic rats. NKV also showed significant protection against arthritis induced oxidative damages.

Gomes, Antony
Bhattacharya, Sourav
Chakraborty, Mousumi
Bhattacharjee, Pushpak
Mishra, Roshnara
Gomes, Aparna
Publication Title: 
Immunopharmacology and Immunotoxicology

The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and their anti-inflammatory activity in carrageenan-induced acute model was evaluated. MJR at a dose of 25 mg/kg showed significantly higher anti-inflammatory effect than EJR, WJR, and standard drug diclofenac. MJR also significantly decreased the paw edema in AIA rats.

Shyni, G. L.
Ratheesh, M.
Sindhu, G.
Helen, A.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Insulin-stimulated muscle glucose uptake is inversely associated with the muscle glycogen concentration. To investigate whether this association is a cause and effect relationship, we compared insulin-stimulated muscle glucose uptake in noncontracted and postcontracted muscle of GSL3-transgenic and wild-type mice. GSL3-transgenic mice overexpress a constitutively active form of glycogen synthase, which results in an abundant storage of muscle glycogen. Muscle contraction was elicited by in situ electrical stimulation of the sciatic nerve.

Fogt, Donovan L.
Pan, Shujia
Lee, Sukho
Ding, Zhenping
Scrimgeour, Angus
Lawrence, John C.
Ivy, John L.
Publication Title: 

BACKGROUND: Developmentally regulated endothelial locus-1 (Del-1) is an extracellular matrix protein that is expressed by endothelial cells during embryological vascular development. We speculated that Del-1 may be reexpressed in ischemia and may be involved in endogenous angiogenesis. METHODS AND RESULTS: Del-1 protein was detected by immunohistochemistry in murine ischemic hindlimb after femoral artery excision. To determine whether exogenous Del-1 would augment angiogenesis in vivo, Del-1 or vehicle was administered for 3 weeks by intramuscular injection of murine ischemic hindlimbs.

Ho, Hoai-Ky V.
Jang, James J.
Kaji, Shuichiro
Spektor, Gary
Fong, Annie
Yang, Phillip
Hu, Bob S.
Schatzman, Randy
Quertermous, Thomas
Cooke, John P.
Publication Title: 
Arthritis Research & Therapy

Complementary and alternative medicine products are increasingly being used for the treatment of autoimmune diseases. However, the mechanisms of action of these agents are not fully defined. Using the rat adjuvant arthritis (AA) model of human rheumatoid arthritis, we determined whether the ethanol extract of Celastrus aculeatus Merr. (Celastrus), a Chinese herb, can down-modulate the severity of AA, and also examined the Celastrus-induced changes in immune responses to the disease-related antigen mycobacterial heat-shock protein 65 (Bhsp65).

Tong, Li
Moudgil, Kamal D.


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