Histamine Antagonists

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Allergic rhinitis is a very common chronic illness affecting 10% to 40% of children worldwide and its prevalence among children has significantly increased over the last two decades. Prevalence and severity are related to age, with children of school age most commonly affected. OBJECTIVES: To assess the effectiveness and adverse event profile of antihistamines (oral or topical) used as an adjunct to topical nasal steroids for intermittent and persistent allergic rhinitis in children.

Author(s): 
Nasser, Mona
Fedorowicz, Zbys
Aljufairi, Hamad
McKerrow, William
Publication Title: 
Wiener Medizinische Wochenschrift (1946)

OBJECTIVE: 1) To assess the efficacy of homeopathic prepared Galphimia glauca compared to placebo in the treatment of pollinosis. 2) To estimate the corresponding overall success rate of Galphimia glauca. Meta-analysis of clinical trials. STUDY SELECTION: 7 randomized double-blind placebo-controlled trials and 4 not placebo-controlled trials (1 randomized and controlled, 1 prospective uncontrolled, 2 retrospective uncontrolled) performed by our study group between 1980 and 1989. An additional MEDLINE search revealed no further trials on this topic.

Author(s): 
Ludtke, R.
Wiesenauer, M.
Publication Title: 
Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

OBJECTIVE: Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1 in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work and school attendance, is responsible for as much as $2 to $4 billion in lost productivity annually.

Author(s): 
Seidman, Michael D.
Gurgel, Richard K.
Lin, Sandra Y.
Schwartz, Seth R.
Baroody, Fuad M.
Bonner, James R.
Dawson, Douglas E.
Dykewicz, Mark S.
Hackell, Jesse M.
Han, Joseph K.
Ishman, Stacey L.
Krouse, Helene J.
Malekzadeh, Sonya
Mims, James Whit W.
Omole, Folashade S.
Reddy, William D.
Wallace, Dana V.
Walsh, Sandra A.
Warren, Barbara E.
Wilson, Meghan N.
Nnacheta, Lorraine C.
Guideline Otolaryngology Development Group. AAO-HNSF
Publication Title: 
Drugs Under Experimental and Clinical Research

Allergic rhinitis, also known as hay fever, rose fever or summer catarrh, is a major challenge to health professionals. A large number of the world's population, including approximately 40 million Americans, suffers from allergic rhinitis. A novel, botanical formulation (Aller-7) has been developed for the treatment of allergic rhinitis using a combination of extracts from seven medicinal plants, including Phyllanthus emblica, Terminalia chebula, T. bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale and P. longum, which have a proven history of efficacy and health benefits.

Author(s): 
Amit, A.
Saxena, V. S.
Pratibha, N.
D'Souza, P.
Bagchi, M.
Bagchi, D.
Stohs, S. J.
Publication Title: 
Anesthesiology

BACKGROUND: The brain histaminergic system plays a critical role in maintenance of arousal. Previous studies suggest that histaminergic neurotransmission might be a potential mediator of general anesthetic actions. However, it is not clear whether histaminergic tuberomamillary nucleus (TMN) is necessarily involved in the sedative/hypnotic effects of general anesthetics. METHODS: Male Long Evans rats underwent either TMN orexin-saporin/sham lesion or implantation of intracerebroventricular cannula 2 weeks before the experiment.

Author(s): 
Luo, Tao
Leung, L. Stan
Publication Title: 
American Family Physician

Atopic dermatitis, also known as atopic eczema, is a chronic pruritic skin condition affecting approximately 17.8 million persons in the United States. It can lead to significant morbidity. A simplified version of the U.K. Working Party's Diagnostic Criteria can help make the diagnosis. Asking about the presence and frequency of symptoms can allow physicians to grade the severity of the disease and response to treatment. Management consists of relieving symptoms and lengthening time between flare-ups. Regular, liberal use of emollients is recommended.

Author(s): 
Berke, Rebecca
Singh, Arshdeep
Guralnick, Mark
Publication Title: 
Malaria Journal

BACKGROUND: Prescription practices have been shown to influence the emergence of anti-malarial drug resistance. Thus efforts in this study were devoted to evaluating the prescribing practices prior to introduction of the artemisinin based combination therapy (ACT) in Nigeria and its potential contribution to emergence of chloroquine resistant malaria in south-west Nigeria, in order to forestall a similar situation with the ACT.

Author(s): 
Gbotosho, Grace O.
Happi, Christian T.
Ganiyu, Abideen
Ogundahunsi, Olumide A.
Sowunmi, Akin
Oduola, Ayoade M.
Publication Title: 
Journal of Ethnopharmacology

The widely known tree Abies pindrow (Talisapatra) (family: Pinaceae), famous for its diverse clinical uses in Ayurvedic medicines, was investigated to rationalise some of the ancient claims. The petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanol (EE) extracts of A. pindrow leaf were found to have mast cell stabilizing action in rats. The EE, AE and BE extracts offered bronchoprotection against histamine challenge in guinea-pigs. The BE, CE and PE extracts had protective role in aspirin-induced ulcer in rats.

Author(s): 
Singh, R. K.
Bhattacharya, S. K.
Acharya, S. B.
Publication Title: 
Journal of Medicinal Food

Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. cepa (bulb) inhibited histamine release and attenuated intracellular calcium levels in Compound 48/80-induced rat peritoneal mast cells. It also prevented Compound 48/80-mediated systemic anaphylaxis while lowering histamine levels in plasma.

Author(s): 
Kaiser, P.
Youssouf, M. S.
Tasduq, S. A.
Singh, S.
Sharma, S. C.
Singh, G. D.
Gupta, V. K.
Gupta, B. D.
Johri, R. K.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Decoctions of Baliospermum montanum Müll. Arg. (Euphorbiaceae) leaves are reported to be useful in the treatment of asthma and other respiratory complications in the Ayurvedic system. OBJECTIVE: To evaluate the mast cell stabilization and antihistaminic activities of the chloroform (BMLC) and ethanol (BMLE) extracts of the leaves of Baliospermum montanum.

Author(s): 
Venkatesh, P.
Mukherjee, Pulok K.
Mukherjee, Debajyoti
Bandyopadhyay, A.
Fukui, Hiroyuki
Mizuguchi, Hiroyuki

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