Histamine H1 Antagonists

Publication Title: 
Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology

LEARNING OBJECTIVES: Reading this article will reinforce the reader's awareness of the adverse effects of medications used for the treatment of rhinitis. DATA SOURCES: Articles on therapy of rhinitis and reports of associated side effects were reviewed. A MEDLINE database using subject keywords was searched from 1992 through 1997. STUDY SELECTION: Pertinent articles were chosen. A distinction was made in the text between controlled studies and case reports.

Author(s): 
Milgrom, H.
Bender, B.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Labour is a normal physiological process, but is usually associated with pain and discomfort. Numerous methods are used to relieve labour pain. These include pharmacological (e.g. epidural, opioids, inhaled analgesia) and non-pharmacological (e.g. hypnosis, acupuncture) methods of pain management. Non-opioid drugs are a pharmacological method used to control mild to moderate pain. OBJECTIVES: To summarise the evidence regarding the effects and safety of the use of non-opioid drugs to relieve pain in labour.

Author(s): 
Othman, Mohammad
Jones, Leanne
Neilson, James P.
Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Atopic eczema is the commonest inflammatory skin disease of childhood, affecting 15-20% of children in the UK at any one time. Adults make up about one-third of all community cases. Moderate-to-severe atopic eczema can have a profound effect on the quality of life for both sufferers and their families.

Author(s): 
Hoare, C.
Li Wan Po, A.
Williams, H.
Publication Title: 
Clinical and Experimental Dermatology

This review provides a summary of key findings from 22 systematic reviews on atopic eczema (AE) published over the 2-year period from January 2012 to 31 December 2013, focusing on prevention and treatment of AE. For an update of systematic reviews on the epidemiology, mechanisms of disease and methodological issues, see Part 1 of this update. Based on current systematic review evidence, the most promising intervention for the prevention of AE is the use of probiotics (and possibly prebiotics) during the late stages of pregnancy and early life.

Author(s): 
Madhok, V.
Futamura, M.
Thomas, K. S.
Barbarot, S.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Labour is a normal physiological process, but is usually associated with pain and discomfort. Numerous methods are used to relieve labour pain. These include pharmacological (e.g. epidural, opioids, inhaled analgesia) and non-pharmacological (e.g. hypnosis, acupuncture) methods of pain management. Non-opioid drugs are a pharmacological method used to control mild to moderate pain. OBJECTIVES: To summarise the evidence regarding the effects and safety of the use of non-opioid drugs to relieve pain in labour.

Author(s): 
Othman, Mohammad
Jones, Leanne
Neilson, James P.
Publication Title: 
Sovetskaia Meditsina
Author(s): 
Zheltakov, M. M.
Skripkin, Iu K.
Somov, B. A.
Publication Title: 
Laryngologie, Rhinologie, Otologie

Conservative therapy of tinnitus presents a theme that is controversial, since the usefulness of almost all the proposed treatments is rarely based on scientific-experimental evidence. The blocking of the stellate ganglion, electric stimulation of the cochlea and the anaesthesia of the plexus tympanicus belong to the domain of surgical treatment methods of tinnitus. Drug therapy is the mainstay of treatment; our own measures are demonstrated.

Author(s): 
Naujoks, J.
Lotter, E.
Publication Title: 
International Dental Journal

Surveys indicate that the adolescent, in particular, suffers from acute anxiety in relation to dentistry. This anxiety is promoted by the general opinion they form of dentists and dentistry through portrayal by their peers and the media. In addition, their own attitude to dentistry, both positive and negative, is influenced to a large extent by the dentist himself. This patient-dentist relationship is, therefore, especially important when treating the adolescent and this should be emphasized in the dental undergraduate curriculum.

Author(s): 
Donaldson, D.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

The effect of oxatomide, an antiallergic drug, on the central and peripheral nervous systems were investigated, and the following results were obtained: Oxatomide at oral doses of 30-100 mg/kg produced little or no effect on the spontaneous and cooperative movements in mice, hexobarbital-induced hypnosis in mice, body temperature in rats, and did not induce muscle relaxation, the analgesic effect, anticonvulsive effects and anti-physostigmine effect. Oxatomide at doses of 300 mg/kg or more produced sedation followed by an increase in the responses to stimuli in mice and rats.

Author(s): 
Ohmori, K.
Ishii, H.
Shuto, K.
Nakamizo, N.
Publication Title: 
Methods and Findings in Experimental and Clinical Pharmacology

The general pharmacological profile and effects of E-4716 on the CNS have been investigated in comparison with other histamine receptor blockers. In in vitro studies with isolated organs and in binding studies on numerous receptors, E-4716 had no activity even at high concentrations, except for the selective blockade of H1 receptors. No activity was observed in pharmacological trials in vivo, such as the Irwin test or analgesia induced by phenylbenzoquinone or electroshock, suggesting a depressant activity on the CNS.

Author(s): 
Fisas, M. A.
Gutiérrez, B.
Fort, M.
Dordal, A.
García, C.
Farré, A. J.

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