Histamine Release

Publication Title: 
Journal of Ethnopharmacology

We investigated the effects of the water soluble fraction of Terminalia chebula (Combretaceae) (WFTC) on systemic and local anaphylaxis. WFTC administered 1h before compound 48/80 injection inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.01-1.0 g/kg. When WFTC was administered 5 or 10 min after compound 48/80 injection, the mortality also decreased in a dose-dependent manner. Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg).

Author(s): 
Shin, T. Y.
Jeong, H. J.
Kim, D. K.
Kim, S. H.
Lee, J. K.
Kim, D. K.
Chae, B. S.
Kim, J. H.
Kang, H. W.
Lee, C. M.
Lee, K. C.
Park, S. T.
Lee, E. J.
Lim, J. P.
Kim, H. M.
Lee, Y. M.
Publication Title: 
Immunology Series

Table 1 summarizes the activities of hemopoietins on immature and mature basophils. IL-3, GM-CSF, and IL-5 enhanced basophil histamine release and in-vitro survival, while G-CSF, M-CSF, and IL-4 had no enhancing activities at all. In addition, IL-3 and GM-CSF induced basophil chemotaxis.

Author(s): 
Hirai, K.
Morita, Y.
Miyamoto, T.
Publication Title: 
Annales De Dermatologie Et De Vénéréologie

INTRODUCTION: Chronic idiopathic urticaria is a frequent disease witch treatment is often disappointing. Psychological factors seem to be frequently associated to it. In what cases consider psychological treatment? And according to what modalities? METHOD: Review of the literature in search of articles in both French and English concerning psychological factors associated to chronic urticaria, either as responsible factors, or as aggravating factors, or as a consequence of the urticaria, with the study of the impact on the quality of life.

Author(s): 
Buffet, M.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Decoctions of Baliospermum montanum Müll. Arg. (Euphorbiaceae) leaves are reported to be useful in the treatment of asthma and other respiratory complications in the Ayurvedic system. OBJECTIVE: To evaluate the mast cell stabilization and antihistaminic activities of the chloroform (BMLC) and ethanol (BMLE) extracts of the leaves of Baliospermum montanum.

Author(s): 
Venkatesh, P.
Mukherjee, Pulok K.
Mukherjee, Debajyoti
Bandyopadhyay, A.
Fukui, Hiroyuki
Mizuguchi, Hiroyuki
Publication Title: 
Journal of Pharmacological Sciences

Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significantly inhibited compound 48/80-induced histamine and beta-hexosaminidase release from rat peritoneal mast cells.

Author(s): 
Na, Ho-Jeong
Moon, Phil-Dong
Ko, Seong-Gum
Lee, Hee-Jung
Jung, Hyun-Ah
Hong, Seung-Heon
Seo, Youngwan
Oh, Jay-Min
Lee, Bong-Ho
Choi, Byoung-Wook
Kim, Hyung-Min
Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]

Myrtaceae is a plant family widely used in folk medicine and Syzygium and Eugenia are among the most important genera. We investigated the anti-allergic properties of an aqueous leaf extract of Syzygium cumini (L.) Skeels (SC). HPLC analysis revealed that hydrolyzable tannins and flavonoids are the major components of the extract. Oral administration of SC (25-100 mg/kg) in Swiss mice (20-25 g; N = 7/group) inhibited paw edema induced by compound 48/80 (50% inhibition, 100 mg/kg; P <or= 0.05) and, to a lesser extent, the allergic paw edema (23% inhibition, 100 mg/kg; P <or= 0.05).

Author(s): 
Brito, F. A.
Lima, L. A.
Ramos, M. F. S.
Nakamura, M. J.
Cavalher-Machado, S. C.
Siani, A. C.
Henriques, M. G. M. O.
Sampaio, A. L. F.
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Royal jelly (RJ), the exclusive food for queen bees, is taken as a dietary supplement because it is highly rich in nutrients. However, RJ is known to induce an anaphylactic response in some individuals. We evaluated in the present study the hypoallergenicity of alkaline protease-treated RJ in vitro and in vivo. We first confirmed that this treated RJ contained the same levels of vitamins, minerals and specific fatty acid as in untreated RJ.

Author(s): 
Moriyama, Tatsuya
Yanagihara, Miyako
Yano, Erika
Kimura, Goro
Seishima, Mariko
Tani, Hiroko
Kanno, Tomoko
Nakamura-Hirota, Tooru
Hashimoto, Ken
Tatefuji, Tomoki
Ogawa, Tadashi
Kawamura, Yukio
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