HLA-DR Antigens

Publication Title: 
Advances in Gerontology = Uspekhi Gerontologii / Rossi?skai?a Akademii?a Nauk, Gerontologicheskoe Obshchestvo

We studied the basic indicators of immune status of healthy persons of different age groups living in the monsoon climate in the southern Far East. The analysis shows age-dependent development of immunodepressive status, combined with increasing levels of CD16, CD25 and HLA-DR in the aging organism. Climatic and anthropogenic factors effect profoundly damaging on the body, which results in the severity of disorders of the immune system in old, old age and longevity.

Author(s): 
Gvozdenko, T. A.
Kytikova, O. Iu
Vitkina, T. I.
Borshchev, P. V.
Publication Title: 
Nature Neuroscience

Using the Illumina 450K array and a stringent statistical analysis with age and gender correction, we report genome-wide differences in DNA methylation between pathology-free regions derived from human multiple sclerosis-affected and control brains. Differences were subtle, but widespread and reproducible in an independent validation cohort. The transcriptional consequences of differential DNA methylation were further defined by genome-wide RNA-sequencing analysis and validated in two independent cohorts.

Author(s): 
Huynh, Jimmy L.
Garg, Paras
Thin, Tin Htwe
Yoo, Seungyeul
Dutta, Ranjan
Trapp, Bruce D.
Haroutunian, Vahram
Zhu, Jun
Donovan, Michael J.
Sharp, Andrew J.
Casaccia, Patrizia
Publication Title: 
Psychological Science

Preferences for mates that possess genes dissimilar to one's own at the major histocompatibility complex (MHC), a polymorphic group of loci associated with the immune system, have been found in mice, birds, fish, and humans. These preferences may help individuals choose genetically compatible mates and may adaptively function to prevent inbreeding or to increase heterozygosity and thereby immunocompetence of offspring. MHC-dissimilar mate preferences may influence the psychology of sexual attraction.

Author(s): 
Garver-Apgar, Christine E.
Gangestad, Steven W.
Thornhill, Randy
Miller, Robert D.
Olp, Jon J.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Correlating phenotypes with genotypes remains the major postgenomic challenge. Attempts to correlate phenotype characteristics associated with ethnicity, geographical divisions, or diseases to genotypes have had limited success. This means that current approaches for identifying phenotypes associated with haplotypes may be inadequate. OBJECTIVES: We hypothesize that a human phenome based on Ayurveda could provide an appropriate approach. Specifically, there could be a genetic basis for the three major constitutions (Prakriti) described in Ayurveda.

Author(s): 
Bhushan, Patwardhan
Kalpana, Joshi
Arvind, Chopra
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Ayurveda, India's natural health care tradition, has a unique way of classifying human population based on individual constitution or prakriti. Ayurveda's tridosha theory identifies principles of motion (vata), metabolism (pitta), and structure (kapha) as discrete phenotypic groupings. Patwardhan et al.

Author(s): 
Patwardhan, Bhushan
Bodeker, Gerard
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Correlating phenotypes with genotypes remains the major postgenomic challenge. Attempts to correlate phenotype characteristics associated with ethnicity, geographical divisions, or diseases to genotypes have had limited success. This means that current approaches for identifying phenotypes associated with haplotypes may be inadequate. OBJECTIVES: We hypothesize that a human phenome based on Ayurveda could provide an appropriate approach. Specifically, there could be a genetic basis for the three major constitutions (Prakriti) described in Ayurveda.

Author(s): 
Bhushan, Patwardhan
Kalpana, Joshi
Arvind, Chopra
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Ayurveda, India's natural health care tradition, has a unique way of classifying human population based on individual constitution or prakriti. Ayurveda's tridosha theory identifies principles of motion (vata), metabolism (pitta), and structure (kapha) as discrete phenotypic groupings. Patwardhan et al.

Author(s): 
Patwardhan, Bhushan
Bodeker, Gerard
Publication Title: 
Blood

CD34+ precursors in normal human bone marrow (BM) generate large numbers of dendritic cells alongside macrophages and granulocytic precursors when cultured for 12 to 14 days in c-kit ligand, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF-alpha). This study reports an intermediate cell type that develops by day 6, and has the potential to differentiate into either macrophages or dendritic cells.

Author(s): 
Szabolcs, P.
Avigan, D.
Gezelter, S.
Ciocon, D. H.
Moore, M. A.
Steinman, R. M.
Young, J. W.
Publication Title: 
The Journal of Allergy and Clinical Immunology

BACKGROUND: The glutathione-S-transferase Mu 1 (GSTM1) null genotype has been reported to be a risk factor for acute respiratory disease associated with increases in ambient air ozone levels. Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects. OBJECTIVE: The purpose of this study was to determine whether the GSTM1 null genotype modulates ozone responses in human subjects.

Author(s): 
Alexis, Neil E.
Zhou, Haibo
Lay, John C.
Harris, Bradford
Hernandez, Michelle L.
Lu, Tsui-Shan
Bromberg, Philip A.
Diaz-Sanchez, David
Devlin, Robert B.
Kleeberger, Steven R.
Peden, David B.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Infection with HIV-1 results in marked immunologic insults and structural damage to the intestinal mucosa, including compromised barrier function. While the development of highly active antiretroviral therapy (HAART) has been a major advancement in the treatment of HIV-1 infection, the need for novel complementary interventions to help restore intestinal structural and functional integrity remains unmet. Known properties of pre-, pro-, and synbiotics suggest that they may be useful tools in achieving this goal.

Author(s): 
Schunter, Marco
Chu, Hiutung
Hayes, Timothy L.
McConnell, Delandy
Crawford, Sean S.
Luciw, Paul A.
Bengmark, Stig
Asmuth, David M.
Brown, Jennifer
Bevins, Charles L.
Shacklett, Barbara L.
Critchfield, J. William

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