Hot Temperature

Publication Title: 
Aging Cell

Molecular advances of the past decade have led to the discovery of a myriad of 'aging genes' (methuselah, Indy, InR, Chico, superoxide dismutase) that extend Drosophila lifespan by up to 85%. Despite this life extension, these mutants are no longer lived than at least some recently wild-caught strains. Typically, long-lived mutants are identified in relatively short-lived genetic backgrounds, and their effects are rarely tested in genetic backgrounds other than the one in which they were isolated or derived.

Spencer, Christine C.
Howell, Christine E.
Wright, Amber R.
Promislow, Daniel E. L.
Publication Title: 
PloS One

The nematode Caenorhabditis elegans has in recent years been proven to be a powerful in vivo model for testing antimicrobial compounds. We report here that the alkaloid compound Harmane (2-methyl-?-carboline) increases the lifespan of nematodes infected with a human pathogen, the Shiga toxin-producing Escherichia coli O157:H7 strain EDL933 and several other bacterial pathogens. This was shown to be unrelated to the weak antibiotic effect of Harmane. Using GFP-expressing E. coli EDL933, we showed that Harmane does not lower the colonization burden in the nematodes.

Jakobsen, Henrik
Bojer, Martin S.
Marinus, Martin G.
Xu, Tao
Struve, Carsten
Krogfelt, Karen A.
L¯bner-Olesen, Anders
Publication Title: 
Mutation Research

Sperm DNA fragmentation (SDF) is not a static seminal parameter, since the longevity of sperm DNA decreases progressively with time following ejaculation or thawing. While the dynamics of SDF is a species-specific characteristic, in the case of humans, there is still significant variation within patients.

Santiso, Rebeca
Tamayo, MarÌa
Gos·lvez, Jaime
Johnston, Steve
MariÒo, Alfonso
Fern·ndez, Carlos
Losada, Carlos
Fern·ndez, JosÈ Luis
Publication Title: 
Expert Opinion on Drug Discovery

INTRODUCTION: Mild stress-induced hormesis is becoming increasingly attractive as an ageing interventional strategy and is leading to the discovery of hormesis-inducing compounds called hormetins.

Rattan, Suresh I. S.
Publication Title: 
Ageing Research Reviews

Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects. Single or multiple exposure to low doses of otherwise harmful agents, such as irradiation, food limitation, heat stress, hypergravity, reactive oxygen species and other free radicals have a variety of anti-aging and longevity-extending hormetic effects.

Rattan, Suresh I. S.
Publication Title: 
PloS One

Rhodiola rosea has been extensively used to improve physical and mental performance and to protect against stress. We, and others, have reported that R. rosea can extend lifespan in flies, worms, and yeast. However, its molecular mechanism is currently unknown. Here, we tested whether R. rosea might act through a pathway related to dietary restriction (DR) that can extend lifespan in a range of model organisms.

Schriner, Samuel E.
Lee, Kevin
Truong, Stephanie
Salvadora, Kathyrn T.
Maler, Steven
Nam, Alexander
Lee, Thomas
Jafari, Mahtab
Publication Title: 

Flies were starved with water before being subjected to various severe stresses (heat, cold, fungal infection, hydrogen peroxide) immediately after starvation or after a delay. Starvation of young and middle-aged flies increased resistance to a long cold stress (0†∞C for up to 48†h), mainly if there was a 2-6†h delay between starvation and the cold stress, but positive effects in old flies were hardly observed. No positive effect was observed on resistance to the other stresses and starvation rather decreased resistance to them.

Le Bourg, …ric
Publication Title: 
Animal: An International Journal of Animal Bioscience

To better understand the mechanisms that allow some animals to sustain their productive effort in harsh environmental conditions, rabbit does from two selection lines (LP and V) were housed in normal (NC), nutritional (NF) or heat (HC) challenging environmental conditions from first to third partum. The LP line (n=85) was founded on reproductive longevity criteria by selecting does from commercial farms that had a minimum of 25 partum with more than 7.5 kits born alive per parity.

Savietto, D.
Cervera, C.
Blas, E.
Baselga, M.
Larsen, T.
Friggens, N. C.
Pascual, J. J.
Publication Title: 
Zeitschrift Für Die Gesamte Experimentelle Medizin
von EIFF, A. W.
Publication Title: 
Clinical Science
Black, S.
Edholm, O. G.
Fox, R. H.
Kidd, D. J.


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