HT29 Cells

Publication Title: 
PloS One

Numerous studies have shown that resistance to oxidative stress is crucial to stay healthy and to reduce the adverse effects of aging. Accordingly, nutritional interventions using antioxidant food-grade compounds or food products are currently an interesting option to help improve health and quality of life in the elderly. Live lactic acid bacteria (LAB) administered in food, such as probiotics, may be good antioxidant candidates. Nevertheless, information about LAB-induced oxidative stress protection is scarce.

Author(s): 
Grompone, Gianfranco
Martorell, Patricia
Llopis, Silvia
Gonz·lez, N˙ria
GenovÈs, Salvador
Mulet, Ana Paula
Fern·ndez-Calero, Tamara
Tiscornia, InÈs
Bollati-FogolÌn, Mariela
Chambaud, Isabelle
FolignÈ, Benoit
Montserrat, AgustÌn
RamÛn, Daniel
Publication Title: 
Molecular Pharmacology

Doxorubicin efficacy in cancer therapy is hampered by the dose-dependent side effects, which may be overcome by reducing the drug's dose and increasing its efficacy. In the present work, we suggest that the activation of the nuclear factor-kappaB (NF-kappaB) pathway and of nitric-oxide (NO) synthase increases the doxorubicin efficacy in human colon cancer HT29 cells.

Author(s): 
Riganti, Chiara
Doublier, Sophie
Costamagna, Costanzo
Aldieri, Elisabetta
Pescarmona, Gianpiero
Ghigo, Dario
Bosia, Amalia
Publication Title: 
Molecules (Basel, Switzerland)

The manuscript describes the synthesis of 10-substituted dihydroartemisinin derivatives containing N-aryl phenylethenesulfonamide groups and their in vitro anti-tumor activities against the HT-29, MDA-MB-231, U87MG, H460, A549 and HL-60 cancer cell lines and the normal WI-38 cell line. Most tested compounds showed enhanced cytotoxic activities and good selectivity toward the MDA-MB-231, HT-29 and HL-60 cell lines, with IC50 values in the single-digit ?M range as compared with dihydroartemisinin (DHA), and all of them displayed less toxicity towards WI-38 cells.

Author(s): 
Liu, Yajing
Liu, Zijian
Shi, Jiyue
Chen, Huimin
Mi, Bin
Li, Peng
Gong, Ping
Publication Title: 
Toxicology

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione or diferuloyl methane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. This substance has been used extensively in Ayurvedic medicine for centuries for its anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer properties linked to its pro-apoptotic and anti-proliferative actions. The underlying mechanisms of these diverse effects are complex, not fully elucidated and subject of intense scientific debate.

Author(s): 
Kössler, Sonja
Nofziger, Charity
Jakab, Martin
Dossena, Silvia
Paulmichl, Markus
Publication Title: 
Journal of Ethnopharmacology

AIMS OF THE STUDY: Achyranthes aspera (Family: Amaranthacea) is a medicinal plant used as an anti-cancer agent in ayurveda, a traditional system of medicine practiced in subcontinental India. The aim of the study was to systematically investigate the anti-proliferative properties of Achyranthes aspera leaves extracted in methanol (LE) on human cancer cells in vitro. MATERIALS AND METHODS: We tested time, dose dependent and specific anti-proliferative activity of LE by clonogenic cell survival assay on human cancer and normal epithelial cell lines in vitro.

Author(s): 
Subbarayan, Pochi R.
Sarkar, Malancha
Impellizzeri, Stefania
Raymo, Francisco
Lokeshwar, Balakrishna L.
Kumar, Pradeep
Agarwal, Ram P.
Ardalan, Bach
Publication Title: 
Toxicology

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione or diferuloyl methane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. This substance has been used extensively in Ayurvedic medicine for centuries for its anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer properties linked to its pro-apoptotic and anti-proliferative actions. The underlying mechanisms of these diverse effects are complex, not fully elucidated and subject of intense scientific debate.

Author(s): 
Kössler, Sonja
Nofziger, Charity
Jakab, Martin
Dossena, Silvia
Paulmichl, Markus
Publication Title: 
Cancer Research

Patients with chronic inflammatory bowel disease have a high risk of colon cancer. The molecules that initiate and promote colon cancer and the cancer pathways altered remain undefined. Here, using in vitro models and a mouse model of colitis, we show that nitric oxide (NO) species induce retinoblastoma protein (pRb) hyperphosphorylation and inactivation, resulting in increased proliferation through the pRb-E2F1 pathway.

Author(s): 
Ying, Lei
Hofseth, Anne B.
Browning, Darren D.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Hofseth, Lorne J.
Publication Title: 
Cancer Research

Diphenyl difluoroketone (EF24), a molecule having structural similarity to curcumin, was reported to inhibit proliferation of a variety of cancer cells in vitro. However, the efficacy and in vivo mechanism of action of EF24 in gastrointestinal cancer cells have not been investigated. Here, we assessed the in vivo therapeutic effects of EF24 on colon cancer cells. Using hexosaminidase assay, we determined that EF24 inhibits proliferation of HCT-116 and HT-29 colon and AGS gastric adenocarcinoma cells but not of mouse embryo fibroblasts.

Author(s): 
Subramaniam, Dharmalingam
May, Randal
Sureban, Sripathi M.
Lee, Katherine B.
George, Robert
Kuppusamy, Periannan
Ramanujam, Rama P.
Hideg, Kalman
Dieckgraefe, Brian K.
Houchen, Courtney W.
Anant, Shrikant
Publication Title: 
Carcinogenesis

Ulcerative colitis (UC) is a dynamic, idiopathic, chronic inflammatory condition associated with a high colon cancer risk. American ginseng has antioxidant properties and targets many of the players in inflammation. The aim of this study was to test whether American ginseng extract prevents and treats colitis. Colitis in mice was induced by the presence of 1% dextran sulfate sodium (DSS) in the drinking water or by 1% oxazolone rectally.

Author(s): 
Jin, Yu
Kotakadi, Venkata S.
Ying, Lei
Hofseth, Anne B.
Cui, Xiangli
Wood, Patricia A.
Windust, Anthony
Matesic, Lydia E.
Pena, Edsel A.
Chiuzan, Codruta
Singh, Narendra P.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Wargovich, Michael J.
Hofseth, Lorne J.
Publication Title: 
International Journal of Oncology

In spite of the global consumption of mushrooms, only two epidemiological studies demonstrated an inverse correlation between mushroom intake and the risk of cancer. Therefore, in the present study we evaluated whether extracts from edible mushrooms Agaricus bisporus (portabella), Flammulina velutipes (enoki), Lentinula edodes (shiitake) and Pleurotus ostreatus (oyster) affect the growth of breast and colon cancer cells. Here, we identified as the most potent, P.

Author(s): 
Jedinak, Andrej
Sliva, Daniel

Pages

Subscribe to RSS - HT29 Cells