Hyaluronic Acid

Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30?years. This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4?years. In addition to their longevity, naked mole rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer.

Author(s): 
Tian, Xiao
Azpurua, Jorge
Hine, Christopher
Vaidya, Amita
Myakishev-Rempel, Max
Ablaeva, Julia
Mao, Zhiyong
Nevo, Eviatar
Gorbunova, Vera
Seluanov, Andrei
Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30?years. This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4?years. In addition to their longevity, naked mole rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer.

Author(s): 
Tian, Xiao
Azpurua, Jorge
Hine, Christopher
Vaidya, Amita
Myakishev-Rempel, Max
Ablaeva, Julia
Mao, Zhiyong
Nevo, Eviatar
Gorbunova, Vera
Seluanov, Andrei
Publication Title: 
Annales De Dermatologie Et De Vénéréologie

BACKGROUND: Technical procedures in dermatology are painful. AIM: The aim of the study was to determine predictive factors for pain in such procedures. PATIENTS AND METHODS: This observational study evaluated pain by means of a numerical pain rating scale and a questionnaire about the circumstances of the pain and the use of analgesic methods. Data were analysed using Excel and SAS software. RESULTS: Five hundred and forty-six questionnaires were analysed. Among the patients, 45.4% had mild pain, 34.5% moderate pain and 20.1% severe pain.

Author(s): 
Talour, K.
Schollhammer, M.
Garlantezec, R.
Quinio, B.
Misery, L.
Publication Title: 
Arzneimittel-Forschung

Two drugs composed of several different plant extracts are in use in Ayurvedic medicine for the treatment of asthma and arthritis, respectively. There is increasing evidence that reactive oxygen species (ROS) arising from several enzymatic reactions are mediators of inflammatory events such as the above mentioned. Plant extracts have the potential for scavenging such reactive oxygen species, dependent on the individual test system.

Author(s): 
Janisch, Kerstin M.
Milde, Jens
Elstner, Erich F.
Publication Title: 
Chemistry & Biology

BACKGROUND: Articular cartilage from patients with osteoarthritis is characterized by a decreased concentration and reduced size of glycosaminoglycans. Degeneration of the cartilage matrix is a multifactorial process, which is due in part to accelerated glycosaminoglycan catabolism. Recently, we have demonstrated that hexosaminidase represents the dominant glycosaminoglycan-degrading glycosidase released by chondrocytes into the extracellular compartment and is the dominant glycosidase in synovial fluid from patients with osteoarthritis.

Author(s): 
Liu, J.
Shikhman, A. R.
Lotz, M. K.
Wong, C. H.
Publication Title: 
Annals of the Rheumatic Diseases

OBJECTIVE: To examine the therapeutic efficacy of N-acetylglucosamine (GlcNAc) in rabbits with experimental osteoarthritis (OA). METHODS: Experimental OA was induced in rabbits by anterior cruciate ligament transection (ACLT). In the first study, rabbits (six in each group) received intramuscular injections of GlcNAc or normal saline three times a week starting 1 week postoperatively. In the second study, rabbits (eight in each group) were injected intra-articularly with GlcNAc (either once or twice a week) or normal saline.

Author(s): 
Shikhman, A. R.
Amiel, D.
D'Lima, D.
Hwang, S.-B.
Hu, C.
Xu, A.
Hashimoto, S.
Kobayashi, K.
Sasho, T.
Lotz, M. K.
Publication Title: 
Cardiovascular Research

AIMS: Inflammation is pivotal in atherosclerosis and a key early step is endothelial dysfunction. C-reactive protein, the prototypic marker of inflammation, and cardiovascular risk marker have been shown to promote atherogenesis. Increased levels of C-reactive protein are associated with endothelial dysfunction. The glycocalyx decorates the luminal surface and affords critical protection of the endothelium. Thus, the aim of the study was to examine the effect of C-reactive protein on the endothelial glycocalyx.

Author(s): 
Devaraj, Sridevi
Yun, Jung-Mi
Adamson, Grete
Galvez, Jose
Jialal, Ishwarlal
Publication Title: 
Diabetes Care

OBJECTIVE: Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing their cardiovascular risk. Toll-like receptors (TLRs) and their ligands play a key role in insulin resistance and atherosclerosis. However, there is a paucity of data examining the expression and activity of TLRs in type 2 diabetes. Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression, their ligands, and signaling in monocytes of recently diagnosed type 2 diabetic patients.

Author(s): 
Dasu, Mohan R.
Devaraj, Sridevi
Park, Samuel
Jialal, Ishwarlal
Publication Title: 
Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

Recent epidemiologic studies quote a prevalence of 5,2% to 63% for dry eye depending on definition. Many risk factors have been identified, among other things the female gender. Dry eye interferes significantly with quality of live. Measurement of the change in temperature and humidity during blinking turned out to be a reliable diagnostic tool. Videokeratoscopy explains well-known visual impairments related to dry eye and, along with lipid film interferometry, provides insight into tear film dynamics. The importance of tear film proteins is underestimated.

Author(s): 
Schirra, F.
Ruprecht, K. W.
Publication Title: 
Geriatrics

Basic objectives of arthritis therapy are to reduce musculoskeletal pain, slow progression of disease, maintain and improve function and quality of life, and avoid adverse drug reactions. Both nonpharmacologic and pharmacologic approaches may be taken. The former include patient education, cognitive therapy, high-intensity progressive-resistance or strength training, weight control, cold therapy, heat, massage, relaxation and distraction techniques.

Author(s): 
Blumstein, Howard
Gorevic, Peter D.

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