Hydroxymethylglutaryl CoA Reductases

Publication Title: 
Hematology/Oncology Clinics of North America

Statin drugs and various isoprenoids from plant origins inhibit mevalonic acids, cholesterol, and other isoprenoid products. Among these, reduction of farnesyl and geranylgeranyl prenylated proteins impedes signal transduction at the cellular level. The authors envision that limiting such prenylated proteins downregulates thrombin-stimulated events, including decreasing the expression and availability of protease-activated receptor-1 mitigating thrombin stimulation of cells, tissue factor preventing additional thrombin generation, and plasminogen activator inhibitor-1 allowing thrombosis.

Author(s): 
Fenton, J. W.
Shen, G. X.
Minnear, F. L.
Brezniak, D. V.
Jeske, W. P.
Walenga, J. M.
Bognacki, J. J.
Ofosu, F. A.
Hassouna, H. I.
Publication Title: 
The International Journal of Neuroscience

The human hypothalamus produces an endogenous membrane Na+-K+ ATPase inhibitor, digoxin, which can regulate neuronal transmission. The digoxin status and neurotransmitter patterns were studied in individuals with a predilection to fall in love. It was also studied in individuals with differing hemispheric dominance to find out the role of cerebral dominance in this respect.

Author(s): 
Kurup, Ravi Kumar
Kurup, Parameswara Achutha
Publication Title: 
Genomics, Proteomics & Bioinformatics

Despite its efficacy against malaria, the relatively low yield (0.01%-0.8%) of artemisinin in Artemisia annua is a serious limitation to the commercialization of the drug. A better understanding of the biosynthetic pathway of artemisinin and its regulation by both exogenous and endogenous factors is essential to improve artemisinin yield. Increasing evidence has shown that microRNAs (miRNAs) play multiple roles in various biological processes. In this study, we used previously known miRNAs from Arabidopsis and rice against expressed sequence tag (EST) database of A.

Author(s): 
Pani, Alok
Mahapatra, Rajani Kanta
Behera, Niranjan
Naik, Pradeep Kumar
Publication Title: 
Oxidative Medicine and Cellular Longevity

The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats.

Author(s): 
Visavadiya, Nishant P.
Narasimhacharya, A. V. R. L.
Publication Title: 
The International Journal of Neuroscience

Ayurveda, the traditional Indian System of Medicine, deals with the theory of the three tridosha states (both physical and psychological): Vata, Pitta, and Kapha. They are the three major human constitutional types that both depend on psychological and physical characteristics. The Pitta state is described as a critical, discriminative, and rational psychological state of mind, while the Kapha state is described as being dominant for emotional stimuli. The Vata state is an intermediate unstable shifting state. The Pitta types are of average height and built with well developed musculature.

Author(s): 
Kurup, Ravi Kumar
Kurup, Parameswara Achutha
Publication Title: 
Journal of Medicinal Food

We have investigated Scoparia dulcis, an indigenous plant used in Ayurvedic medicine in India, for its possible antihyperlipidemic effect in rats with streptozotocin-induced experimental diabetes. Oral administration of an aqueous extract of S.

Author(s): 
Pari, Leelavinothan
Latha, Muniappan
Publication Title: 
Oxidative Medicine and Cellular Longevity

The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats.

Author(s): 
Visavadiya, Nishant P.
Narasimhacharya, A. V. R. L.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia arjuna - stem bark extract is traditionally used as cardiotonic in Ayurvedic medicine. AIM OF THE STUDY: The present study was aimed to evaluate the molecular basis for cardioprotective potential of Terminalia arjuna (TA) stem bark, using cell cultures of human monocytic (THP-1) and human aortic endothelial cells (HAECs).

Author(s): 
Kokkiripati, Praveen K.
Kamsala, Ratnam V.
Bashyam, Leena
Manthapuram, Nalini
Bitla, Prasanth
Peddada, Vidyadhari
Raghavendra, Agepati S.
Tetali, Sarada D.
Publication Title: 
The Journal of Nutrition

Soy intake reduces cholesterol levels. However, both the identity of the soy component or components that contribute to this reduction and the cellular mechanism producing this reduction are unknown. Soy consists of protein, lipids, fiber, and phytochemicals including isoflavones. We propose that the isoflavone component of soy mediates this effect, at least in part, by affecting cellular sterol homeostasis.

Author(s): 
Mullen, Eimear
Brown, Rachel M.
Osborne, Timothy F.
Shay, Neil F.
Publication Title: 
The Journal of Nutritional Biochemistry

Recent studies have demonstrated that green and black tea consumption can lower serum cholesterol in animals and in man, and suppression of hepatic cholesterol synthesis is suggested to contribute to this effect. To evaluate this hypothesis, we measured cholesterol synthesis in cultured rat hepatoma cells in the presence of green and black tea extracts and selected components. Green and black tea decreased cholesterol synthesis by up to 55% and 78%, respectively, as measured by a 3-h incorporation of radiolabeled acetate.

Author(s): 
Singh, Dev K.
Banerjee, Subhashis
Porter, Todd D.

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