Hyperlipidemias

Publication Title: 
Journal of Natural Medicines

Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring countries, and the fruit of this plant has been reported to have hypoglycemic and hypolipidemic effects. In this study, we investigated the preventive effect of a hot water extract of T.

Author(s): 
Makihara, Hiroko
Shimada, Tsutomu
Machida, Eriko
Oota, Masatomi
Nagamine, Rika
Tsubata, Masahito
Kinoshita, Kaoru
Takahashi, Kunio
Aburada, Masaki
Publication Title: 
Circulation

BACKGROUND: Prospective studies indicate that baseline levels of C-reactive protein (CRP), the prototypic marker of inflammation, are associated with an increased risk for cardiovascular events. Limited studies have examined therapies that influence high-sensitive CRP (hs-CRP) levels, especially in hyperlipidemic patients.

Author(s): 
Jialal, I.
Stein, D.
Balis, D.
Grundy, S. M.
Adams-Huet, B.
Devaraj, S.
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

Clinical trials with statins have demonstrated significant reductions in cardiovascular events. Remnant lipoproteins are independent predictors of cardiovascular events. Because of the paucity of data on the effect of statins on remnant lipoproteins, we tested the effect of pravastatin, simvastatin, and atorvastatin on remnant lipoprotein cholesterol (RLP-C) levels in a randomized crossover study in patients with combined hyperlipidemia.

Author(s): 
Stein, D. T.
Devaraj, S.
Balis, D.
Adams-Huet, B.
Jialal, I.
Publication Title: 
American Family Physician

Omega-3 fatty acids have been shown to significantly reduce the risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease. Fatty fish, such as salmon and tuna, and fish oil are rich sources of the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid. Flaxseed, canola oil, and walnuts also are good dietary sources of omega-3 fatty acids. In addition to being antiarrhythmic, the omega-3 fatty acids are antithrombotic and anti-inflammatory.

Author(s): 
Covington, Maggie B.
Publication Title: 
Climacteric: The Journal of the International Menopause Society

INTRODUCTION: Menopause is associated with mid-life, a time when many women begin to experience the signs and symptoms of aging, such as increases in blood pressure, changes in lipid profiles, loss of bone mass density, and diminished memory and cognition. Given the result of the Women's Health Initiative, many women no longer consider hormone therapy the first option for promoting healthy aging. Instead, they are turning to botanical and dietary supplement (BDS) products in place of hormone therapy.

Author(s): 
Geller, S. E.
Studee, L.
Publication Title: 
The American Journal of Clinical Nutrition

Changes in diet over the past century have markedly altered the consumption of fatty acids. The dramatic increase in the ingestion of saturated and n-6 fatty acids and concomitant decrease in n-3 fatty acids are thought to be a major driver of the increase in the incidence of inflammatory diseases such as asthma, allergy, and atherosclerosis.

Author(s): 
Chilton, Floyd H.
Rudel, Lawrence L.
Parks, John S.
Arm, Jonathan P.
Seeds, Michael C.
Publication Title: 
Archives of Pathology & Laboratory Medicine

CONTEXT: Inflammation is pivotal to atherosclerosis. The monocyte-macrophage, a crucial cell in atherogenesis, is present during all stages of atherosclerosis. However, there is a paucity of data comparing circulating monocytes to cholesterol-laden macrophages (foam cells), with regard to their atherogenic properties, especially in subjects with established risk factors such as hyperlipidemia.

Author(s): 
Devaraj, Sridevi
Jialal, Ishwarlal
Publication Title: 
Heart Failure Clinics

Vascular endothelial dysfunction is determined by both genetic and environmental factors that cause decreased bioavailability of the vasodilator nitric oxide. This is a hallmark of atherosclerosis, hypertension, and coronary heart disease, which are major complications of metabolic disorders, including diabetes and obesity. Several therapeutic interventions, including changes in lifestyle as well as pharmacologic treatments, are useful for improving endothelial dysfunction in the face of lipotoxicity.

Author(s): 
Kim, Jeong-a
Montagnani, Monica
Chandrasekran, Sruti
Quon, Michael J.
Publication Title: 
Fitoterapia

The effectiveness of Hibiscus sabdariffa L. (HS) in the treatment of risk factors associated with cardiovascular disease is assessed in this review by taking a comprehensive approach to interpreting the randomized clinical trial (RCT) results in the context of the available ethnomedical, phytochemical, pharmacological, and safety and toxicity information. HS decoctions and infusions of calyxes, and on occasion leaves, are used in at least 10 countries worldwide in the treatment of hypertension and hyperlipidemia with no reported adverse events or side effects.

Author(s): 
Hopkins, Allison L.
Lamm, Marnie G.
Funk, Janet L.
Ritenbaugh, Cheryl
Publication Title: 
Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing

The purpose of this integrative review is to describe and assess randomized controlled trials of interventions to reduce peripheral arterial disease (PAD) risk factors among African Americans, given the high morbidity and mortality associated with PAD and the poorer outcomes in African Americans with PAD. The reviewed studies include non-pharmacological interventions aimed at the reduction of hemoglobin A1c, blood pressure and lipids in African-American patients with the causal PAD risk factors of diabetes, hypertension and hyperlipidemia.

Author(s): 
Eastridge, Diana K.

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