Hyperlipidemias

Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

PURPOSE: Gynostemma pentaphyllum is widely used in traditional Chinese medicine. Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol. Our studies examine anti-hyperlipidemic effects of gypenosides. METHODS: Gynostemma activity was examined in poloxamer P407 induced hyperlipidemia in rats. RESULTS: 1 g/kg P407 induced plasma triglyceride (25 fold), total cholesterol (6 fold), low density lipoprotein cholesterol (LDL) (7 fold), high density lipoprotein cholesterol (HDL) (1.6 fold), and nitrite (8 fold).

Author(s): 
Megalli, Samer
Aktan, Fugen
Davies, Neal M.
Roufogalis, Basil D.
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol. We have examined the pharmacological anti-hyperlipidemic and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density lipoprotein cholesterol levels (33%). These effects were dose-dependent and maintained for at least 5 weeks.

Author(s): 
Megalli, Samer
Davies, Neal M.
Roufogalis, Basil D.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To analyze the clinical features of severe acute pancreatitis (SAP) in aged patients, and to explore the measures of its diagnosis and treatment. METHODS: The clinical data of 100 aged patients (55-85 years old) with SAP admitted from January 2003 to December 2005 were reviewed and compared with those of 221 non-aged SAP patients (11-54 years old) admitted at the same period. RESULTS: Totally 112 times of onset occurred in 100 aged patients, and the main causes for senile SAP were biliary diseases and hyperlipemia.

Author(s): 
Huang, Wei
Xue, Ping
Liu, Ting-ting
Huang, Lei
Xiang, Da-Kai
Wang, Lei
Xia, Qing
Publication Title: 
Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University

OBJECTIVE: To observe the effects of Qingzhi soft capsule, a preparation of traditional Chinese medicine, on blood lipid level and the pathology of fatty degeneration of the liver in rats with hyperlipidemia. METHODS: SD rats were subjected to daily intragastric administration of a high-cholesterol emulsion (10 ml/kg) every morning to induce hyperlipidemia.

Author(s): 
Tong, Li
Chen, Yu-Yao
Guo, You-Li
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the therapeutic effect of Yihuo Qingxia method, a traditional Chinese medicine therapeutic method for replenishing qi to activate blood, clearing away heat and dredging intestines, in treating hyperlipoidemia-related severe acute pancreatitis (SAP) in early stage. METHODS: One hundred and four patients with hyperlipoidemia-related SAP were divided into two groups: early group (admitted to hospital within 3 days after onset) and late group (admitted to hospital from 3 days to 7 days after onset). There were 52 cases in each group.

Author(s): 
Xue, Ping
Deng, Li-Hui
Zhang, Zhao-da
Xia, Qing
Huang, Zong-wen
Yang, Xiao-nan
Jiang, Jun-ming
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the relationship between the plasma biomarker proteins and the states of Zang-Fu organs in patients with phlegm or blood stagnation syndromes due to hyperlipidemia and atherosclerosis. METHODS: The states of Zang-Fu organs in 146 patients with hyperlipidemia and atherosclerosis were diagnosed by syndrome differentiation of traditional Chinese medicine. The plasma proteins from these patients were separated by two-dimensional polyacrylamide gel electrophoresis (2-DE).

Author(s): 
Song, Jian-nan
Liu, Jun-lian
Fang, Xiang-zhong
Hu, Yuan-hui
Lei, Yan
Niu, Xiao-hong
Wu, Gang
Chen, Bao-sheng
Ma, Ya-luan
Chen, Bing
Jin, Hong
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To observe the effects of Huanglian Jiedu Decoction (HJD), a compound traditional Chinese herbal medicine, on lipid metabolism and its related gene expressions in rats with hyperlipidemia. METHODS: Fifty SD rats were randomly divided into normal control group, untreated group, Lipitor (atorvastatin) group, and low- and high-dose HJD groups. Except the normal control group, rats in the other groups were fed with high-fat diet to induce hyperlipidemia. Then the rats were administered with corresponding drugs for 8 weeks.

Author(s): 
Jin, Jin
Zhang, Yang
Hu, Wen-xiang
Zhang, Zheng-yao
Xu, Nan-nan
Zhou, Qiu-li
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The Daming capsule (DMC) is a traditional Chinese medicine used to treat hyperlipoidemia. Both clinic trials and studies on animal models have demonstrated that DMC is beneficial against diabetic symptoms. Impairment of the baroreflex can cause life-threatening arrhythmias and sudden cardiac death in patients with diabetes mellitus (DM). This study was designed to elucidate the effects of DMC on baroreflexes in streptozocin (STZ)-induced diabetic rats with hyperlipoidemia.

Author(s): 
Ai, Jing
Wang, Li-Hong
Zhang, Rong
Qiao, Guo-Fen
Wang, Ning
Sun, Li-hua
Lu, Guan-Yi
Sun, Chao
Yang, Bao-Feng
Publication Title: 
Journal of Medicinal Food

Cynanchum wilfordii is used in traditional Chinese medicine with almost all parts of this plant considered beneficial for various vascular diseases. This study was performed to evaluate the effect of an ethanol extract of C. wilfordii (ECW) on vascular dysfunction in apolipoprotein E (apoE)(-/-) mice fed with high fat/cholesterol diets (HFCDs). The apoE(-/-) mice were fed HFCD consisting of 7.5% cocoa butter and 1.25% cholesterol, with or without 100 or 200 mg/day/kg ECW.

Author(s): 
Choi, Deok Ho
Lee, Yun Jung
Oh, Hyun Cheol
Cui, Ying Lan
Kim, Jin Sook
Kang, Dae Gill
Lee, Ho Sub
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: T'ai chi chuan (TCC) is a traditional Chinese exercise and is beneficial for health. Nevertheless, its effect on cardiovascular risk factors in dyslipidemic patients is not clear. The aim of this study was to evaluate the effect of TCC training on coronary heart disease (CHD) risk factors in patients with dyslipidemia. DESIGN: This was designed as a case-controlled study. SETTING: The study was conducted in a community setting. SUBJECTS: Fifty-three (53) patients (males: 24; females: 29) with dyslipidemia completed this study.

Author(s): 
Lan, Ching
Su, Ta-Chen
Chen, Ssu-Yuan
Lai, Jin-Shin

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