Hypersensitivity, Delayed

Publication Title: 
Allergy

Cutaneous reactivity against histamine skin prick test (Type I) and purified tuberculin protein derivative (Mantoux reaction, Type IV) was studied in eight volunteers under hypnosis. Types I and IV immunoreactivity were modulated by direct suggestion (Type I) and guided imagery (Type IV). The volunteers were highly susceptible subjects, selected by means of the Harvard Group Scale of Hypnotic Susceptibility, Form A.

Author(s): 
Zachariae, R.
Bjerring, P.
Arendt-Nielsen, L.
Publication Title: 
JAMA

OBJECTIVE: To determine whether individuals selected for good general health, high hypnotizability, and the ability to alter skin temperature under hypnotic suggestion can influence the delayed-type hypersensitivity (DTH) response to varicella-zoster (VZ) antigen under hypnotic suggestion. DESIGN: A blinded clinical trial using a repeated measures design with subjects serving as their own controls.

Author(s): 
Locke, S. E.
Ransil, B. J.
Zachariae, R.
Molay, F.
Tollins, K.
Covino, N. A.
Danforth, D.
Publication Title: 
Acta Pharmacologica Sinica

AIM: To study the immunosuppressive activity of SM735 {[3-(12-beta-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal anti-inflammatory drug structure, with the aim of finding potential immunosuppressive agents. METHODS: Concanavalin A (ConA), lipopolysaccharide (LPS), and mixed lymphocyte reaction (MLR), were used to induce the proliferation of splenocytes, and [3H]-thymidine incorporation was used to evaluate the proliferation of splenocytes.

Author(s): 
Zhou, Wen-liang
Wu, Jin-ming
Wu, Qing-Li
Wang, Jun-Xia
Zhou, Yu
Zhou, Ru
He, Pei-Lan
Li, Xiao-yu
Yang, Yi-fu
Zhang, Yu
Li, Ying
Zuo, Jian-ping
Publication Title: 
British Journal of Pharmacology

BACKGROUND AND PURPOSE: Artemisinin and its derivatives exhibit potent immunosuppressive activity. The purpose of the current study was to examine the immunosuppressive activity of artemether directly on T lymphocytes and to explore its potential mode of action. EXPERIMENTAL APPROACH: In vitro, T-cell proliferation was measured using [(3)H]-thymidine incorporation assay in cells stimulated with ConA, alloantigen and anti-CD3 antibody. CFSE-labeled cell division and cell cycle distribution were monitored by flow cytometry.

Author(s): 
Wang, J.-X.
Tang, W.
Shi, L.-P.
Wan, J.
Zhou, R.
Ni, J.
Fu, Y.-F.
Yang, Y.-F.
Li, Y.
Zuo, J.-P.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The leaves of Stachytarpheta cayennensis C. Rich. (Verbenaceae) have been reported to possess potent anti-inflammatory and anti-malarial activities. Due to close association between inflammatory and immune responses, we evaluated the immunomodulatory activity of leaves extract of S. cayennensis. The combined effects of the leaves extract and artesunate, a standard antimalarial agent with immunomodulatory effects, were also evaluated. METHODS: The immunomodulatory activity of the methanol extract of the leaves of S.

Author(s): 
Okoye, Theophine C.
Akah, Peter A.
Ezike, Adaobi C.
Uzor, Philip F.
Odoh, Uchenna E.
Igboeme, Sebastian O.
Onwuka, Uchechi B.
Okafor, Sunday N.
Publication Title: 
Psychoneuroendocrinology

Despite aromatherapy's popularity, efficacy data are scant, and potential mechanisms are controversial. This randomized controlled trial examined the psychological, autonomic, endocrine, and immune consequences of one purported relaxant odor (lavender), one stimulant odor (lemon), and a no-odor control (water), before and after a stressor (cold pressor); 56 healthy men and women were exposed to each of the odors during three separate visits.

Author(s): 
Kiecolt-Glaser, Janice K.
Graham, Jennifer E.
Malarkey, William B.
Porter, Kyle
Lemeshow, Stanley
Glaser, Ronald
Publication Title: 
Journal of Ethnopharmacology

The immunobiological activity was investigated of certain medicinal plants widely used in the Ayurvedic and Unani systems of medicine for treatment of chronic infections and immunological disorders. The effect of an ethanolic extract of each drug was studied on delayed type hypersensitivity, humoral responses to sheep red blood cells, skin allograft rejection, and phagocytic activity of the reticuloendothelial system in mice. Picrorhiza kurroa was found to be a potent immunostimulant, stimulating both cell-mediated and humoral immunity.

Author(s): 
Atal, C. K.
Sharma, M. L.
Kaul, A.
Khajuria, A.
Publication Title: 
Journal of Ethnopharmacology

Semecarpus anacardium nuts are used for variety of disorders in Ayurveda. A chloroform extract of the nut significantly reduced acute carrageenan-induced paw oedema in rats and was active against the secondary lesions of adjuvant-induced arthritis. Delayed hypersensitivity induced in mice by sheep red blood cells as an antigen was potentiated by the extract.

Author(s): 
Saraf, M. N.
Ghooi, R. B.
Patwardhan, B. K.
Publication Title: 
Journal of Ethnopharmacology

The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, i.e. extracts from Ashwagandha, Withania somnifera (L.) Dunal (Solanaceae), namely WST and WS2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (DTH). Immunomodulatory effect was assessed in If IgE-mediated anaphylaxis as reduction of ovalbumin-induced paw edema, in animals treated with WS2 at doses of 150 and 300 mg/kg, and the results were compared with the standard drug disodium chromoglycate.

Author(s): 
Agarwal, R.
Diwanay, S.
Patki, P.
Patwardhan, B.
Publication Title: 
Journal of Ethnopharmacology

Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial. AIMS OF THE STUDY: The present study involved the investigation of immunomodulatory activities of ethanolic extract of Caesalpinia bonducella seeds.

Author(s): 
Shukla, Shruti
Mehta, Archana
John, Jinu
Mehta, Pradeep
Vyas, Suresh Prasad
Shukla, Savita

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