Hypoglycemia

Publication Title: 
Diabetes Therapy: Research, Treatment and Education of Diabetes and Related Disorders

INTRODUCTION: Recent large randomized controlled trials highlighted the clinical significance of hypoglycemic episodes in the treatment of diabetes. The present survey was conducted to provide information from real-life practice on the incidence of hypoglycemia in type 2 diabetic patients treated with sulfonylureas. METHODS: This multicenter, observational, cross-sectional study collected data on incidence of side effects of sulfonylurea-based therapy in type 2 diabetic patients in four countries of the Balkan region (Slovenia, Croatia, Serbia, Bulgaria) from October 2014 to June 2015.

Author(s): 
Majanovic, Sanja Klobucar
Janez, Andrej
Lefterov, Ivaylo
Tasic, Sanja
Cikac, Tatjana
Publication Title: 
Comprehensive Therapy

It appears inevitable that with increased longevity, the management of the elderly diabetic will place even greater demands on hospital services. It seems reasonable to adopt a more liberal attitude to the regulation of control of diabetes in the elderly than in younger patients. However, the view that diabetes in the elderly is always mild can be dangerously misleading. A significant number of elderly diabetics develop ketoacidosis or other serious forms of metabolic disturbance, and in these patients the mortality is high.

Author(s): 
Walsh, C. H.
Publication Title: 
Journal of the American Dental Association (1939)

BACKGROUND: The prevalence of diabetes mellitus, or DM, in the United States is increasing steadily. The increasing longevity of the American population and more effective diagnostic protocols mean that the dental practitioner will be treating an increasing number of patients with the disease. METHODS: The authors present relevant information about DM, including a recently revised nomenclature system, pathophysiology, complications, new diagnostic criteria, medical and dental management considerations, and associated oral conditions.

Author(s): 
Lalla, R. V.
D'Ambrosio, J. A.
Publication Title: 
Diabetes Research and Clinical Practice

AIMS: We explored people's reasons for, and experiences of, using bolus advisors to determine insulin doses; and, their likes/dislikes of this technology. SUBJECTS AND METHODS: 42 people with type 1 diabetes who had received instruction in use of bolus advisors during a structured education course were interviewed post-course and 6 months later. Data were analysed thematically. RESULTS: Participants who considered themselves to have poor mathematical skills highlighted a gratitude for, and heavy reliance on, advisors.

Author(s): 
Lawton, J.
Kirkham, J.
Rankin, D.
Barnard, K.
Cooper, C. L.
Taylor, C.
Heller, S.
Elliott, J.
REPOSE Group
Publication Title: 
Diabetes Technology & Therapeutics

BACKGROUND: The aims of this study were (1) to demonstrate the reliability and validity of the Impact of Weight on Activities of Daily Living Questionnaire (IWADL), a measure of ability to perform daily physical activities, in individuals with type 2 diabetes who are moderately obese and (2) to characterize those individuals with low self-reported ability. METHODS: Data from a web-based survey of individuals with type 2 diabetes and body mass index (BMI) of 30-40?k/mg(2) were used to calculate Cronbach's ? and demonstrate both IWADL factorial and construct validity.

Author(s): 
Hayes, Risa P.
Nelson, David R.
Meldahl, Michael L.
Curtis, Bradley H.
Publication Title: 
Malaria Journal

BACKGROUND: Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS: Of 151 patients with presumed severe malaria, 23 children with blood glucose concentrations < 60 mg/dl (< 3.3 mmol/l) were assigned randomly to receive either intravenous 10% glucose (IVG; n = 9) or sublingual sugar (SLS; n = 14).

Author(s): 
Graz, Bertrand
Dicko, Moussa
Willcox, Merlin L.
Lambert, Bernard
Falquet, Jacques
Forster, Mathieu
Giani, Sergio
Diakite, Chiaka
Dembele, Eugène M.
Diallo, Drissa
Barennes, Hubert
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Rosemary, Rosmarinus officinalis L., has several therapeutic applications in folk medicine for the treatment of a wide range of diseases, including depression.

Author(s): 
Machado, Daniele G.
Cunha, Mauricio P.
Neis, Vivian B.
Balen, Grasiela O.
Colla, André R.
Grando, Jaine
Brocardo, Patricia S.
Bettio, Luis E. B.
Dalmarco, Juliana B.
Rial, Daniel
Prediger, Rui D.
Pizzolatti, Moacir G.
Rodrigues, Ana Lúcia S.
Publication Title: 
World journal of gastroenterology: WJG

Persistent hyperinsulinemic hypoglycemia is caused most commonly by an insulinoma in adults or by nesidioblastosis in neonates. In adults, nesidioblastosis is a rare disorder characterized by diffuse or disseminated proliferation of islet cells. We recently encountered a case of nesidioblastosis in an adult. A 71-year-old man was admitted due to intermittent general weakness, abdominal pain, and mild dyspnea. The patient underwent a subtotal gastrectomy for a gastric adenocarcinoma two years ago.

Author(s): 
Hong, Ran
Choi, Dong-Youl
Lim, Sung-Chul
Publication Title: 
Diabetes Care

OBJECTIVE Continuous beta-cell rest with diazoxide preserves residual endogenous insulin production in type 1 diabetes. However, side effects have hampered therapeutic usefulness. In a double-blind study, we tested whether lower, intermittent dosing of diazoxide had beneficial effects on insulin production, metabolic control, and autoimmunity markers in the absence of side effects. RESEARCH DESIGN AND METHODS Forty-one newly diagnosed type 1 diabetic patients were randomized to 6 months of treatment with placebo or 100 mg diazoxide at bedtime.

Author(s): 
Radtke, Maria Anita
Nermoen, Ingrid
Kollind, Magnus
Skeie, Svein
Sørheim, Jan Inge
Svartberg, Johan
Hals, Ingrid
Moen, Torolf
Dørflinger, Gry Høst
Grill, Valdemar
Publication Title: 
Endocrinologia Japonica

Alterations in catecholamine (CA) and thyroid hormone metabolism were examined in a 12-year-old girl with anorexia nervosa during 3 months of treatment. According to her body weight change, the observation period was divided into 3 stages: initial emaciation (stage 1), stable maintenance of the -30% level of the previous weight (stage 2) and convalescent stage (stage 3).

Author(s): 
Sato, T.
Igarashi, N.
Miyagawa, K.
Nakajima, T.
Katayama, K.

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