I-kappa B Proteins

Publication Title: 
Circulation

BACKGROUND: Nuclear factor-?B (NF-?B) signaling plays critical roles in physiological and pathological processes such as responses to inflammation and oxidative stress. METHODS AND RESULTS: To examine the role of endothelial NF-?B signaling in vivo, we generated transgenic mice expressing dominant-negative I?B under the Tie2 promoter/enhancer (E-DNI?B mice). These mice exhibited functional inhibition of NF-?B signaling specifically in endothelial cells.

Author(s): 
Hasegawa, Yutaka
Saito, Tokuo
Ogihara, Takehide
Ishigaki, Yasushi
Yamada, Tetsuya
Imai, Junta
Uno, Kenji
Gao, Junhong
Kaneko, Keizo
Shimosawa, Tatsuo
Asano, Tomoichiro
Fujita, Toshiro
Oka, Yoshitomo
Katagiri, Hideki
Publication Title: 
PloS One

Microglial activation plays an important role in neuroinflammation, which contributes to neuronal damage, and inhibition of microglial activation may have therapeutic benefits that could alleviate the progression of neurodegeneration. Recent studies have indicated that the antimalarial agent artemisinin has the ability to inhibit NF-?B activation. In this study, the inhibitory effects of artemisinin on the production of proinflammatory mediators were investigated in lipopolysaccharide (LPS)-stimulated primary microglia.

Author(s): 
Zhu, Cansheng
Xiong, Zhaojun
Chen, Xiaohong
Peng, Fuhua
Hu, Xueqiang
Chen, Yanming
Wang, Qing
Publication Title: 
The Tohoku Journal of Experimental Medicine

Myocardial infarction (MI) leads to progressive left ventricular (LV) dilatation and is associated with interstitial fibrosis in the non-infarcted myocardium. The NF-?B signaling pathway plays an important role in ventricular remodeling after MI. Recent studies have indicated that the anti-malarial agent artemisinin can inhibit NF-?B activation, which may attenuate post-infarct myocardial remodeling. In this study, we investigated the effect of artemisinin on post-infarct myocardial remodeling using a rat model of MI.

Author(s): 
Gu, Yongwei
Wang, Xi
Wang, Xin
Yuan, Mingjie
Wu, Gang
Hu, Juan
Tang, Yanhong
Huang, Congxin
Publication Title: 
Molecular Cancer Therapeutics

Pinitol (3-O-methyl-chiroinositol), a component of traditional Ayurvedic medicine (talisapatra), has been shown to exhibit anti-inflammatory and antidiabetic activities through undefined mechanisms. Because the transcription factor nuclear factor-kappaB (NF-kappaB) has been linked with inflammatory diseases, including insulin resistance, we hypothesized that pinitol must mediate its effects through modulation of NF-kappaB activation pathway. We found that pinitol suppressed NF-kappaB activation induced by inflammatory stimuli and carcinogens. This suppression was not specific to cell type.

Author(s): 
Sethi, Gautam
Ahn, Kwang Seok
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
Carcinogenesis

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.

Author(s): 
Sarfaraz, Sami
Siddiqui, Imtiaz A.
Syed, Deeba N.
Afaq, Farrukh
Mukhtar, Hasan
Publication Title: 
BMC genomics

BACKGROUND: Nuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of cellular processes involved in the immune response, differentiation, cell proliferation, and apoptosis. The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, AIDS and cancer. Thus there lies a huge therapeutic potential beneath inhibition of NF-κB signalling pathway for reducing these chronic ailments.

Author(s): 
Grover, Abhinav
Shandilya, Ashutosh
Punetha, Ankita
Bisaria, Virendra S.
Sundar, Durai
Publication Title: 
Molecular Cancer Therapeutics

Bone loss is one of the major complications of advanced cancers such as breast cancer, prostate cancer, and multiple myeloma; agents that can suppress this bone loss have therapeutic potential. Extensive research within the last decade has revealed that RANKL, a member of the tumor necrosis factor superfamily, plays a major role in cancer-associated bone resorption and thus is a therapeutic target.

Author(s): 
Sung, Bokyung
Oyajobi, Babatunde
Aggarwal, Bharat B.
Publication Title: 
Molecular Cancer Therapeutics

Pinitol (3-O-methyl-chiroinositol), a component of traditional Ayurvedic medicine (talisapatra), has been shown to exhibit anti-inflammatory and antidiabetic activities through undefined mechanisms. Because the transcription factor nuclear factor-kappaB (NF-kappaB) has been linked with inflammatory diseases, including insulin resistance, we hypothesized that pinitol must mediate its effects through modulation of NF-kappaB activation pathway. We found that pinitol suppressed NF-kappaB activation induced by inflammatory stimuli and carcinogens. This suppression was not specific to cell type.

Author(s): 
Sethi, Gautam
Ahn, Kwang Seok
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
Carcinogenesis

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.

Author(s): 
Sarfaraz, Sami
Siddiqui, Imtiaz A.
Syed, Deeba N.
Afaq, Farrukh
Mukhtar, Hasan
Publication Title: 
BMC genomics

BACKGROUND: Nuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of cellular processes involved in the immune response, differentiation, cell proliferation, and apoptosis. The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, AIDS and cancer. Thus there lies a huge therapeutic potential beneath inhibition of NF-κB signalling pathway for reducing these chronic ailments.

Author(s): 
Grover, Abhinav
Shandilya, Ashutosh
Punetha, Ankita
Bisaria, Virendra S.
Sundar, Durai

Pages

Subscribe to RSS - I-kappa B Proteins