Image Processing, Computer-Assisted

Publication Title: 
Acta Cytologica

ISSUES: Optical digital imaging and its related technologies have applications in cytopathology that encompass training and education, image analysis, diagnosis, report documentation and archiving, and telecommunications. Telecytology involves the use of telecommunications to transmit cytology images for the purposes of diagnosis, consultation or education.

O'Brien, M. J.
Takahashi, M.
Brugal, G.
Christen, H.
Gahm, T.
Goodell, R. M.
Karakitsos, P.
Knesel, E. A.
Kobler, T.
Kyrkou, K. A.
Labbe, S.
Long, E. L.
Mango, L. J.
McGoogan, E.
Oberholzer, M.
Reith, A.
Winkler, C.
Publication Title: 
PloS One

BACKGROUND: The mechanisms of action underlying acupuncture, including acupuncture point specificity, are not well understood. In the previous decade, an increasing number of studies have applied fMRI to investigate brain response to acupuncture stimulation. Our aim was to provide a systematic overview of acupuncture fMRI research considering the following aspects: 1) differences between verum and sham acupuncture, 2) differences due to various methods of acupuncture manipulation, 3) differences between patients and healthy volunteers, 4) differences between different acupuncture points.

Huang, Wenjing
Pach, Daniel
Napadow, Vitaly
Park, Kyungmo
Long, Xiangyu
Neumann, Jane
Maeda, Yumi
Nierhaus, Till
Liang, Fanrong
Witt, Claudia M.
Publication Title: 
Investigative Ophthalmology & Visual Science

PURPOSE: To investigate the migratory and contractile behavior of isolated human corneal fibroblasts in fibrillar collagen matrices. METHODS: A telomerase-infected, extended-lifespan human corneal fibroblast cell line (HTK) was transfected by using a vector for enhanced green fluorescent protein (GFP)-alpha-actinin. Cells were plated at low density on top of or within 100-microm-thick fibrillar collagen lattices. After 18 hours to 7 days, time-lapse imaging was performed.

Vishwanath, Mridula
Ma, Lisha
Otey, Carol A.
Jester, James V.
Petroll, W. Matthew
Publication Title: 
Aging Cell

Atrophy is one of the major age-related changes in the brain. The absence of brain atrophy in elderly individuals reflects deceleration in the process of biological aging. Moreover, results from human twin studies suggest a large genetic influence on the variance of human brain tissue volumes. To investigate the association of brain volumes with exceptional longevity, we tested whether middle-aged to elderly offspring of nonagenarian siblings have larger brain volumes than their spouses using magnetic resonance imaging.

Altmann-Schneider, Irmhild
de Craen, Anton J. M.
Slagboom, Pieternella E.
Westendorp, Rudi G. J.
van Buchem, Mark A.
Maier, Andrea B.
van der Grond, Jeroen
Publication Title: 
Molecular Psychiatry

General intelligence is a robust predictor of important life outcomes, including educational and occupational attainment, successfully managing everyday life situations, good health and longevity. Some neuronal correlates of intelligence have been discovered, mainly indicating that larger cortices in widespread parieto-frontal brain networks and efficient neuronal information processing support higher intelligence. However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning.

Penke, L.
Maniega, S. MuÒoz
Bastin, M. E.
ValdÈs Hern·ndez, M. C.
Murray, C.
Royle, N. A.
Starr, J. M.
Wardlaw, J. M.
Deary, I. J.
Publication Title: 
Journal of Anatomy

Radially oriented ensembles of neurons and their projections, termed minicolumns, are hypothesized to be the basic microcircuit of mammalian cerebral cortex. Minicolumns can be divided into a core and a peripheral neuropil space compartment. The core of minicolumns is constrained by the migratory path of pyramidal cells and their attendant radially oriented projections. Variation in minicolumnar morphometry and density is observed both within and across species.

Casanova, Manuel F.
Trippe, Juan
Tillquist, Christopher
Switala, Andrew E.
Publication Title: 
Human Brain Mapping

BACKGROUND: The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown to be affected by stress, trauma, or maltreatment and are regarded to be involved in the etiology of affective disorders.

Dannlowski, Udo
Kugel, Harald
Redlich, Ronny
Halik, Adriane
Schneider, Ilona
Opel, Nils
Grotegerd, Dominik
Schwarte, Kathrin
Schettler, Christiane
AmbrÈe, Oliver
Rust, Stephan
Domschke, Katharina
Arolt, Volker
Heindel, Walter
Baune, Bernhard T.
Suslow, Thomas
Zhang, Weiqi
Hohoff, Christa
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

Recent evidence suggests that altered expression and epigenetic modification of the glucocorticoid receptor gene (NR3C1) are related to the risk of post-traumatic stress disorder (PTSD). The underlying mechanisms, however, remain unknown. Because glucocorticoid receptor signaling is known to regulate emotional memory processes, particularly in men, epigenetic modifications of NR3C1 might affect the strength of traumatic memories.

Vukojevic, Vanja
Kolassa, Iris-T.
Fastenrath, Matthias
Gschwind, Leo
Spalek, Klara
Milnik, Annette
Heck, Angela
Vogler, Christian
Wilker, Sarah
Demougin, Philippe
Peter, Fabian
Atucha, Erika
Stetak, Attila
Roozendaal, Benno
Elbert, Thomas
Papassotiropoulos, Andreas
de Quervain, Dominique J.-F.
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

Multiple genetic approaches have identified microRNAs as key effectors in psychiatric disorders as they post-transcriptionally regulate expression of thousands of target genes. However, their role in specific psychiatric diseases remains poorly understood. In addition, epigenetic mechanisms such as DNA methylation, which affect the expression of both microRNAs and coding genes, are critical for our understanding of molecular mechanisms in schizophrenia.

Hass, Johanna
Walton, Esther
Wright, Carrie
Beyer, Andreas
Scholz, Markus
Turner, Jessica
Liu, Jingyu
Smolka, Michael N.
Roessner, Veit
Sponheim, Scott R.
Gollub, Randy L.
Calhoun, Vince D.
Ehrlich, Stefan
Publication Title: 
Schizophrenia Research

Both methylation and brain volume patterns hold important biological information for the development and prognosis of schizophrenia (SZ). A combined study to probe the association between them provides a new perspective to understanding SZ. Genomic methylation of peripheral blood and regional brain volumes derived from magnetic resonance imaging were analyzed using parallel independent component analyses in this study. Nine methylation components and five brain volumetric components were extracted for 94 SZ patients and 106 healthy controls.

Liu, Jingyu
Siyahhan Julnes, Peter
Chen, Jiayu
Ehrlich, Stefan
Walton, Esther
Calhoun, Vince D.


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